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Dr. Len's Cancer Blog

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Vitamins (20 posts)  RSS

Ultraviolet Bad: Surgeon General Issues A Call To Action To Prevent Skin Cancer

by Dr. Len July 31, 2014

(Note: This blog was originally published on another American Cancer Society website on July 29 because of technical problems on this site. Those have now been resolved and it is now reposted here. We appreciate your understanding.)


"Ultraviolet bad."

That was the core message that came out of the introduction Tuesday morning of the Surgeon General's Call to Action to Prevent Skin Cancer at a meeting held at the National Press Club in Washington DC.

There were some other messages that now raise skin cancer awareness and prevention high on the public health awareness list, such as the fact that over 5 million people every year have a diagnosis of skin cancer (and many have more than one skin cancer), and that we are spending over $8 billion dollars treating the disease. But most important is the fact that this is one of the most preventable cancers, and if current trends are any indication we are not getting the job done when it comes to decreasing the number of skin cancers and saving lives. More...

On "Don't Fry Day" Remember To Be Safe In The Sun: You Can Fry Your Chicken But Don't Fry Yourself

by Dr. Len May 24, 2013

Today is the beginning of Memorial Day weekend and the summer holiday season. It's a day to remember to enjoy your fried chicken, while not frying your skin. (OK, fried chicken isn't exactly healthy for you, but it is fun once in a while. Frying your skin is never healthy nor fun).

It is also Don't Fry Day, an annual reminder of the need to be sun safe while we enjoy the outdoors during the summer months. More...

Filed Under:

Other cancers | Prevention | Vitamins

Will My Smartphone Help Me End The Purgatory Of My Groundhog Day Diet?

by Dr. Len February 04, 2013

OK. So Groundhog Day was on Saturday this year, and unlike the furry little beast what I have to say each year around this time is just as good today as him looking for his shadow on Saturday.

What is all this about, you are probably asking yourself?

It is about an annual update that I started a couple of years ago on my blog to remind myself and those who are interested that losing weight and staying healthy is a tough slog and a major commitment which too often is not successful. Like many of you out there I am not immune to all the problems surrounding diet and trying to get weight under control. Try, try, try again and again, and hopefully one day we can all get it "right." That's why I dubbed this the Groundhog Day Diet, after the Bill Murray movie of a similar name where he strikes out to relive the same day again and again until he gets it "right."

And, let's face it: I am not alone in this dilemma. Many of us are in the same boat: we keep trying, but nothing seems to work. There are temptations and messages all around us that are leading us to eat ourselves into oblivion. We as a nation are becoming larger and larger, and now there are concerns that overweight and obesity-if left unchecked, and on their current trajectory-will result in reversal of the gains we have made in extending and improving life. But maybe--just maybe--with the new techologies offered by apps and smarphones we will be able to actually take control of our lives and our eating habits and make some real progress through more awareness and information in realtime at the moment we are making our choices about our diets. More...

Filed Under:

Diet | Environment | Prevention | Vitamins

Genomics Leads To An "Aha!" Moment And Closes The Loop On Tanning Beds And Melanoma Risk

by Dr. Len June 04, 2012

Yesterday I wrote a blog discussing how meetings like the current annual gathering of the American Society of Clinical Oncology (ASCO) gives me a chance to think about big picture questions.


Well, there is another side to the experience that is also interesting and important, such as getting information that helps put together pieces of a larger puzzle, and perhaps even gives closure to a nagging question. When you have one of those "Aha!!!" moments, it can truly solidify your thoughts and maybe even save a few lives in the process. In this case, the same presentation that led to yesterday's comments about the emerging complexities of the diagnosis of cancer also produced another enlightening moment.


Dr. Levi Garraway is a highly regarded genomics researcher from Dana Farber Cancer Institute in Boston who presented a lecture on the topic of how genome sequencing is bringing new insights to the biology and treatment of cancer. As part of his presentation, Dr. Garraway offered information on areas where genomics has already offered us definitive information that has direct implications in understanding cancer.


The #1 item on Dr. Garraway's list was a topic of intense interest to me and several of my skin cancer colleagues.


According to Dr. Garraway, genetic analysis of cancers from patients with melanoma show an overwhelming number (my words) have a signature genetic marker proving their melanomas were caused by ultraviolet (UV) radiation. He elaborated that there have been questions in the scientific literature as to whether or not this was the case, and acknowledged that we have had to rely on relatively indirect research to prove the case that melanoma is caused by UV light. However, he continued, because of genomics it is now essentially "case closed" and essentially proven: melanoma is caused by exposure to UV light. More...

Where Have You Gone Vitamin D?

by Dr. Len March 23, 2011

Oh, vitamin D, where have ye gone?  We miss ya!!


That might be the refrain of many who have labored so long to promote awareness of vitamin D as a possible cancer prevention agent for the past number of years. 


Not that the advocates have lost their faith-a recent article from Dr. Cedric Garland, who is an expert on vitamin D as a case in point-but a report from the Institute of Medicine (IOM) has thrown a bit of a damper on the unbridled enthusiasm that vitamin D was the answer to cancer prevention that many have been seeking for some time.


No, the IOM did not endorse vitamin D as a cancer prevention agent.  And based on what they could say from the literature, the panel did endorse the concept that vitamin D is important for bone health, while blood tests that reportedly showed substantial deficiencies throughout the United States were in fact not being appropriately interpreted.


Now, in a "Perspective" piece in this week's New England Journal of Medicine, three of the IOM panel members share their thoughts with the public as to why the panel did not reach the conclusion that vitamin D decreases cancer risk.  And, while they support that conclusion, they also don't lose sight of the possibility that there may just be some truth behind the claims-bit it hasn't been proven just yet. More...

Maybe It's Time To Ban The Tan

by Dr. Len January 28, 2010

Now that the tanning industry has had its nosed bloodied by the Federal Trade Commission, maybe it’s time for the Food and Drug Administration to step up to the plate.


That’s the question that is looming large for many interested in the issue of tanning bed risk, and the upcoming FDA meeting on March 25 where further restrictions on tanning beds are going to be considered.


From my point of view, and based on my personal/family experience, action can't come soon enough.


This is clearly not a new topic.


Several years ago, the World Health Organization published a detailed, comprehensive report on the risks of tanning beds.  They concluded they were bad for your health, and recommended that youth under the age of 18 should be banned from using them.


Fast forward to this past July, and you have the International Agency for Research in Cancer—better known as IARC—issuing a statement that tanning beds are in fact a Class I carcinogen, on the same page and same line as tobacco.


In other words, just like tobacco, here is a product that when used as intended has a considerable chance of causing you harm.  And, at the same time, it is unclear except in the most limited of circumstances how tanning beds can possibly offer any benefit that can’t be achieved using approaches that are much less risky at substantially less cost.


In very condensed terms, what happened this past Tuesday was that the FTC charged the Indoor Tanning Association (ITA)—a trade industry that is supported by the tanning industry—of “making false health and safety claims about indoor tanning.”  According to the FTC press release, the association simultaneously “agreed to a settlement that bars it from any further deception.”


So what did they “decept” you might ask?


In a March 2008 advertising campaign—one that raised great concern among those aware of the risks of indoor tanning—the Association claimed:


·        Indoor tanning is approved by the government


·        Indoor tanning is safer than tanning outdoors because the amount of ultraviolet light received when tanning indoors is monitored and controlled


·        Research shows that vitamin D supplements may harm the body’s ability to fight disease, and


·        A national Academy of Sciences study determined that “the risks of not getting enough ultraviolet light far outweigh the hypothetical risk of skin cancer.”


As part of the settlement, the industry has to let people know that they don’t have to become tan to get vitamin D and that doing so “may increase the likelihood of developing skin cancer and can cause serious eye injury.”


When you look at a more detailed report of the FTC investigation, you find that the industry actually claimed—according to the FTC—that indoor tanning does not increase the risk of skin cancer.  The FTC countered that “tanning, including indoor tanning, increases the risk of skin cancer, including squamous cell and melanoma skin cancers.”


I distinctly remember the advertisements in question. 


Some of us were so concerned that—through the National Council on Skin Cancer Prevention—we actually wrote a letter to the ombudsman of a major national newspaper that ran the ads, taking them to task for running an advertisement that was clearly full of dangerous misinformation.  To the best of my knowledge, we never received a response.


And then there was the article that appeared in the New England Journal of Medicine that provided an excellent review of vitamin D but also included tanning beds as a means of supplementing vitamin D.  We complained about that as well, but the editor declined to run our letter.


Shortly thereafter, there were published reports  and an article on this blog discussing the fact that the researcher who wrote the article indicated that his research was supported by the Ultraviolet Foundation, which is a “foundation” wholly supported by the ITA.


So the battle goes on an on.


This past November, I had the privilege of testifying on behalf of the American Cancer Society at a hearing in Howard County MD that resulted in a county-wide ban on the use of tanning beds by minors under the age of 18.  This was an outright ban, not one of those “if your parents give you permission it’s OK” types of restrictions.


The room was filled with people in favor and opposed to the ban, and to be certain there were a number of tanning salon owners there who said they don’t want to harm children, and feel that tanning is safe (there were also a number of people there who had a strange looking tan, but that’s not a topic for this blog.  They just looked really out of place.)


There were also experts there who testified on behalf of the tanning salon owners.  One of those was a recently retired FDA official who just happened to be intimately involved with tanning bed regulation at the FDA prior to his retirement.


We are going to have a replay of that hearing on March 25th at an FDA advisory committee meeting just outside of Washington DC, when the FDA is going to consider whether they should reclassify tanning lamps from their “essentially safe” list to one that has a bit more teeth. 

That, at least, would reflect current thinking on the question that these lamps are not safe when used as intended, and in fact can cause serious harm.


Like many things in life, this all comes down to one’s personal experiences.  And my family has had one of those experiences.


When my daughter was in high school, she succumbed to the lure of the tanning industry and wanted to get tan for her prom.


As you might imagine, she never told me or consulted with me about this.  After all, dear old Dad may have some knowledge about these things, but what does he really know?


Well, Dad may not know anything but my daughter soon discovered the problem with tanning beds.


You see, she has what is called “type I” skin.  That means she is very fair, and can’t tan.  She burns.


And that’s how I found out that my daughter was going to the “tanning” salon.  She returned home one Saturday, red as a lobster from head to toe, burned by one of those salons that allegedly always follows the rules.  And now she is at a lifetime increased risk of skin cancer and melanoma as a direct result of her sessions under the “safe” UV light in a local tanning salon.


I guess I shouldn’t be surprised.


Researchers have documented the dangers of tanning devices.  They have also documented the lack of controls on the tanning industry.


So I ask you, why?  Why continue this charade?  Why let this go on? 


Tanning isn’t something we need.  It’s something we want—for all the wrong reasons. It can even be addicting like cigarettes.  And, like cigarettes, when used as intended it does bad things—even causing cancer that can result in death—and doesn’t do anything good that can’t be done otherwise more safely, more effectively and less expensively.


I say it’s time for the FDA to follow the lead of the FTC and get on with the job that has to be done.


And, as reflected in a number of bills and proposed regulations currently pending in state and local legislative and regulatory bodies around the country, it’s time to ban the tan—especially for those under the age of 18.

Filed Under:

Other cancers | Prevention | Vitamins

Vitamin D Fails To Decrease Breast Cancer Risk

by Dr. Len November 11, 2008

Finally, we have the results of a large scale randomized, placebo-controlled clinical trial to tell us whether or not vitamin D can reduce the risk of breast cancer.


The study, reported in today’s issue of the Journal of the National Cancer Institute, concludes that there is no evidence that vitamin D decreases breast cancer incidence in post-menopausal women.


But I will bet you dollars-to-doughnuts (well, maybe not doughnuts—they are fattening) that this study isn’t going to provide closure to the hotly-debated question of whether or not vitamin D reduces breast cancer risk.


The study was part of the larger Women’s Health Initiative which was designed to look at the impact of hormone therapy on the health of post-menopausal women.  As part of that study, close to 18000 post-menopausal women were randomly assigned to take 1000 mg of calcium and 400 IU (international units—the recommended daily allowance for vitamin D) daily.  The other 18,000 women took placebos.


The problem is that both groups of women were allowed to take extra vitamin D and calcium, and a good number of them did just that—although the number of women who did so was basically the same in both groups. By year 6 of the trial, about half of the women in both groups were taking extra vitamin D.


The end result was that over the seven years of this study, there was no difference in the frequency of breast cancer between the two groups.  The vitamin D did not make a difference in how often women developed breast cancer.


An editorial that accompanied the report pointed out some of the problems with the study, and which I would also consider important:


  • There were large number of women took vitamin D and calcium on their own, even if they were selected as part of the vitamin D treatment group or as part of the placebo group.  


  • Breast cancer takes a long time to develop in most women.  Seven years may simply not be enough time to detect a benefit that may have been seen if the study was longer. 


  • It is possible based on the results of other studies that vitamin D would be more effective if given to pre-menopausal women as opposed to post-menopausal women as was the case in this study. 


  • Some experts recommend a fairly high dose of vitamin D to prevent cancer which is much greater than that studied here (however, if women were taking vitamin D on their own, it is quite possible that they were taking doses greater than 1000 units a day).


In the same editorial, the authors wrote:


“Because preclinical, epidemiological, and clinical trial results of vitamin D supplementation are conflicting, additional studies will be needed to determine whether vitamin D plus calcium will prevent breast cancer…Future clinical trials should address the above questions to help determine whether higher does of vitamin D supplements will be cancer preventive.  The potential health benefits of vitamin D and calcium may yet have a bright future.”


Another interesting finding pointed out by the authors of the research report was that vitamin D blood levels measured at the beginning of the study didn’t necessarily relate that closely to the amount of vitamin D that the women had been taking in the past.  High vitamin D intake did not necessarily mean high vitamin D levels in the blood.  That raises the question of how much vitamin D our bodies absorb when we take supplements.  Those amounts may be different in different people, and may be controlled by other factors such as our genetic makeup.


The authors concluded:


“Such results suggest that factors other than dietary and supplement intake of vitamin D likely influence (blood levels of vitamin D)…Before future clinical trials of high-dose vitamin D regimens to reduce breast cancer risk are implemented, it will be important to demonstrate that the selected vitamin D dose can definitively increase (blood vitamin D) levels to the projected target level.  Definitive assessment of factors that influence the relationship between vitamin D supplement use and subsequent changes in circulating (vitamin) D levels are therefore a research priority.”


The bottom line?


When it comes to vitamin D there are a lot of questions and not many answers.


For now, we would be hard-pressed to conclude that vitamin D reduces the risk of breast cancer in post-menopausal women.


There is still a lot we don't know:  we don't know how much vitamin D is healthy in our bodies, and if in fact there are risks associated with too much vitamin D (see prior blog).  We don't know whether or not we should be routinely measuring vitamin D in our bodies with blood tests.  We don't know how much vitamin D we should be taking every day, and whether each person responds the same way to the same dose of vitamin D.  We don't know whether vitamin D reduces cancer risk or influences outcome after cancer is diagnosed and for which cancers, if any.


Unfortunately, when it comes to vitamin D, confusion reigns supreme.  We deserve better.

Filed Under:

Breast Cancer | Prevention | Vitamins

Vitamins And Cancer: Looking In The Wrong Places

by Dr. Len November 05, 2008

Are we looking for cancer prevention clues in all the wrong places?  That is the question I am asking myself as another vitamin theory bites the dust.


A report in this week’s Journal of the American Medical Association (and supported in part by research funding from the American Cancer Society) examined the relationship between folic acid, vitamin B6 and vitamin B12 and breast cancer.


The bad news? A combination vitamin pill did not reduce the risk of breast cancer. 


The good news? A combination vitamin pill did not increase the risk of breast cancer, or any other cancer.


In the study, the researchers examined the effect of giving a daily dose of the three vitamins in a single pill to a group of women who were at high risk of heart disease.  Half the participants received the vitamins, and the other half took a placebo (or dummy pill) that did not contain the vitamins.


After a little over 7 years of treatment, there was no difference between the two groups of women with respect to the incidence of breast cancer or any other cancer.  There was also no difference in the frequency of cancer deaths between the two groups


The theory behind this research was that these particular vitamins play an important role in orderly cell growth, and therefore may prevent cancer. 


The reason the theory is so attractive is the same as it is for every vitamin claim: vitamins are easy to take, inexpensive, and thought to be harmless.  For many of us, they are a part of our daily routine.  What could be easier than popping a vitamin pill in the morning to prevent cancer and a host of other diseases?


The problem is—as it has been for many years—that when the vitamin claims are subjected to the magnifying glass of a well-done clinical trial, the claims simply don’t hold up.


Trust me, I know.  Years ago, vitamin C and vitamin E were the rage.  I took them until the research didn’t support the claims that they reduced the risk of cancer and heart disease, respectively. 


Then there was folate, which many of us take that as part of our daily multivitamin tablets.


First folate was reported to reduce the risk of colorectal cancer.  More recently, some research suggests that folate may promote polyp growth for people who already have colon polyps possibly resulting in an increased risk of colon cancer.


To be honest, the research on the risks and benefits of folate in colorectal cancer is conflicting and confusing to medical experts, let alone people who are trying to make the right decisions about their health.


This is important, since beginning in 1998 folate was added to our food in an effort to reduce the incidence of a certain birth defect in the spinal cord.  The food fortification program has been successful, and blood levels of folate in our bodies have increased over the past decade.


But now there is concern—in part because of the research results noted above—that too much folate may actually cause harm, and increase the risk of some cancers.


That’s why this study’s negative outcome is so important: folate did not increase the incidence of colorectal cancer or any other cancer.


Do you find yourself asking the question how something so simple—and so “natural”--as a vitamin can hurt people? 


If we hadn’t done the research, we would all be taking large doses of vitamin C to prevent cancer (it doesn’t).  We would never have found out that beta carotene leads to an increased risk of lung cancer in heavy smokers.  We wouldn’t know that vitamin E and selenium—alone or in combination—did nothing to reduce prostate cancer in men.


Next on my list is vitamin D.  But we won’t have definitive answers to questions about the cancer-related benefits and risks of the “sunshine vitamin” for years.


Maybe we are looking for cancer prevention in all the wrong places, and maybe not. 


It would be great if something as simple as a vitamin pill would ward off the risk of cancer.  Right now, however, the vitamins aren’t scoring any home runs in the cancer prevention arena.    


For now, we are just going to have to do things the old fashioned way: eat your five fruits and vegetables a day, maintain a healthy weight, eat a balanced diet, and exercise, exercise, exercise.


I know.  That’s much more complicated than taking a vitamin pill once a day.  But at least we know those are strategies that work for reducing your risk of cancer.


Broccoli, anyone?







Filed Under:

Breast Cancer | Prevention | Vitamins

Prostate Cancer: Selenium And Vitamin E Don't Work

by Dr. Len October 27, 2008

Just because it’s “natural” and looks like it might work to prevent cancer doesn’t mean it will work to prevent cancer.


That’s the message of today’s announcement from the National Cancer Institute and the Southwest Oncology Group (which is a national research group that does clinical trials in cancer) that they are telling the over 35,000 men participating in a prostate cancer prevention trial to stop taking their pills.


The study, called “SELECT” and which was started in 2001, was based on two earlier trials that found pretty much by accident that it appeared selenium and vitamin E decreased the incidence of prostate cancer. 


Both of those studies were designed to primarily look at cancers other than prostate cancer. One, in Finland, was done to see if vitamin E reduced lung cancer incidence and the other examined the impact of selenium on the incidence of skin cancer.  In both of the studies, there was tempting data that selenium or vitamin E unexpectedly reduced the risk of prostate cancer.


But those “accidental findings” didn’t hold up in a well-designed clinical trial.  Life is not always simple in medical research.


After 7 years, the results are in: An independent review board which monitored the SELECT trial found selenium and vitamin E—either alone or in combination—did not reduce the risk of developing prostate cancer.  In fact, there was a small but not significant increase in the incidence of prostate cancer in the men taking only vitamin E and diabetes in the men taking only selenium.


The result: men are being instructed to stop their pills, but will continue to be monitored for several years.


The theories that vitamin E or selenium can reduce the risk of prostate cancer have been around for awhile.   There were many men who already believed that vitamin E and selenium could reduce the risk of prostate cancer.  But, once subjected to critical study through a randomized clinical trial—the gold standard of medical research—we find the evidence didn’t support the theories.


We have been here before with various vitamins and minerals.  And, there are those out there who have been suggesting that other vitamins and minerals can reduce cancer risk.


This blog is no stranger to evidence based medicine.  No matter how tempting the reports of success may be, until the right trial is done you simply can’t authoritatively support an unproven theory that a vitamin or anything else can prevent cancer.


Let’s always keep that principle in mind before we start advocating that “this thing” or “that thing” prevents cancer.


Until the evidence is in, the evidence isn’t in.

Vitamin D: More Words Of Caution

by Dr. Len August 13, 2008

A study in the current issue of the Archives of Internal Medicine addresses a question that has interested me for some time: does vitamin D really reduce the risk of death for the general population?


The study, from Johns Hopkins in Baltimore and the Albert Einstein College of Medicine in New York, examined data from a national health survey performed in the United States from 1988 through 1994.


The studies did back up the claim that vitamin D deficiency is associated with an increased risk of death in the general population, but did not show that it reduced deaths from all types of cancer. 


Perhaps even more important to me was an observation in the report that suggested there may indeed be an increase in death rates for women who have higher levels of vitamin D in their blood.


The authors noted that approximately 41% of men and 53% of women in the United States are deficient in vitamin D based on prior studies.


The researchers examined data from a nationwide health survey that was performed in the United States from 1988 through 1994.  They evaluated health-related surveys, physical examinations and blood samples that were obtained from 13,331 people representative of the United States population who were 20 years or older.  They then examined the causes of death in this group through December 31, 2000.


In this study, the profile of people who had the lowest levels of vitamin D was older age, female, and non-Hispanic black.  People with low vitamin D levels in this study also tended to include those with higher blood pressures, higher body mass index or BMI (reflecting a greater incidence of overweight and obesity), diabetes, lower socioeconomic status and less physical activity when compared to people with higher levels of vitamin D.


When the researchers looked carefully at the rates of death from any cause, the 20% of the people studied with the lowest level of vitamin D in their blood had a 26% increased chance of death.  Many of the people in this group also were smokers and had other medical illnesses, but the authors were able to discount those factors as contributing to the increased death rate they observed


Unlike heart disease, the investigators found no evidence that vitamin D levels had any influence on the risk of dying from cancers of all types. 


When looking only at death rates for cancers which had previously been associated with vitamin D—including colorectal, breast and prostate cancer—there was no association seen in those who were most vitamin D deficient.  There was a suggestion of lower death rates for those specific cancers at a slightly higher vitamin level—which was still deficient, but not the most seriously deficient group. 


And then there was the graph I came across when looking at the paper.


You may recall back in June I reported on a study presented at ASCO which demonstrated that higher vitamin D levels in post-menopausal women diagnosed with breast cancer were associated with a better prognosis.


In the same study—reported at the meeting but not included in the abstract—there was a slide showing death rates from all causes in women who participated in the study.


In that study, as expected based on the conclusions of the research, the slide showed that women who presented with primary breast cancer and were deficient in vitamin D had a higher death rate compared to women with the middle range of vitamin D levels.


But it was the other end of the curve that gave me cause for concern, namely that the researchers in that study also observed an increased death rate from “other causes” at the higher vitamin D levels found in some of the women.  Those deaths were not from breast cancer, and the research did not point to any specific reason.


The researcher who presented the paper noted the finding, but also indicated that it had to be confirmed by other studies.


That was the first time that I had heard that people from an otherwise “normal” population (except for their breast cancer, of course) had an increased risk of death related to higher—but still acceptable--vitamin D levels.


We must always bear in mind that there may be many explanations for that observation, since the study wasn’t designed to measure that specific outcome.  It could be related to some other factor, or may have occurred just by chance.


Then there was the graph in the current study, and that graph showed a similar curve.  I can’t explain all the statistical considerations, but the graph showed that the women in this study who had higher levels of vitamin D in their blood also had what appears to be either a significant or a borderline significantly increased risk of death from all causes.


They really didn’t say much about the increased mortality rates seen in the 20% of the women in the study with the highest levels of vitamin D in their blood.


“This is the first study, to our knowledge, to explore the association between (vitamin D) levels and mortality in the general population…


“As shown, in women, having both low (<20 ng/ml) and high (>50 ng/ml) (vitamin levels) was associated with an increased rate of mortality. (Emphasis mine)


“Several authors have commented that the optimal levels of (vitamin D) should be greater than 30 ng/ml.  In our observational study, we found that there was a lower risk of mortality at levels of 30-49 ng/ml, but that at levels greater than 50 ng/ml, there was again a higher risk of mortality in women. (Emphasis mine) This is similar to findings about antioxidant vitamins and vitamin E, which show that too much may be harmful.”


I have to say that seeing this information in two separate studies certainly raises a concern as to whether or not this observation is real.  When you start to see a pattern like this in studies of this size, then one’s instinct is to start to pay attention to the finding.


If it is real, then the statement that there is no risk to having high levels of vitamin D—or trying to raise vitamin D levels beyond a “normal” or “middle” range—may not be correct.  Seeing two independent studies point in the same direction is suggestive that this is something worthy of further investigation.  It is not conclusive of evidence of harm.


As I have written previously, there is much yet that we need to learn about this vitamin and its role in health.  But before we can start making recommendations that people take large quantities of vitamin D, we need to know whether there in fact may be a serious mortality risk involved, especially for women.


Vitamin D deficiency is a cause for real concern in this country.  There is no doubt that many people in this country are vitamin D deficient, and that deficiency impacts their bone health, and may impact their overall health as well.


What we need to do now is look at a total strategy regarding vitamin D, beginning with a review of dietary guidelines and how all of this information plays into the everyday practice of medicine.  We need better understanding of the precise role of vitamin D in relationship to health and to cancer specifically.  We need to know if there is benefit from routinely measuring vitamin D levels as part of our general medical care, and what the best advice is regarding replacement and follow-up measurement.  We need to educate the public and the profession alike about vitamin D, but at the same time we need to understand the limitations of our knowledge.


This study did suggest that vitamin D deficiency is associated with an increased death rate from all causes, and supported in some cancers that there may be a relationship between vitamin D levels and the risk of cancer death.


But we also need to know if there is a downside, and the magnitude of risk from that downside.


As the authors clearly pointed out, we have been down this path before. 


Vitamins are assumed to be “safe” because they are “natural.”  But when studied carefully in some situations where there were claims of health benefits, they have been shown not only to not have a health benefit, but have actually caused harm.


As has been said, those that forget the past are condemned to repeat it. On the other hand, for the sake of our physical well-being, we also need evidence-based answers for the questions related to the relationship between vitamin D and our health.


Filed Under:

Diet | Prevention | Vitamins

About Dr. Len

Dr. Len

J. Leonard Lichtenfeld, MD, MACP - Dr. Lichtenfeld is Deputy Chief Medical Officer for the national office of the American Cancer Society.