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The American Cancer Society

Smoking And Cancer Treatment: Danger Ahead

by Dr. Len January 23, 2009

You’ve been diagnosed with cancer.  You are either being treated for cancer, or you have completed your treatment, survived and have moved on with life.  Naturally, you will do everything you can to improve your chances that your treatment will be successful and that the cancer won’t recur.  And, that you will do what you can to reduce the odds of developing another cancer somewhere in your body.

 

Not so fast.  If you are a smoker, a recent study published in the Journal of Oncology Practice suggests that if you follow the above scenario, you are the exception and not the rule.

 

You may be among those who think that once someone has cancer, we should let them alone to deal with their disease and its treatment and stop harping about stopping smoking.  But the medical evidence doesn’t support that notion.

 

We have known for years that continued smoking during cancer treatment can interfere with the success of that treatment.  And, longer term, it can lead to an increased risk of developing other cancers.

 

Research has shown that smoking after a cancer diagnosis interferes with chemotherapy, surgery and radiation therapy according to the study.  It can slow wound healing after surgery, increases the risk of side effects from radiation therapy, and decreases the response to radiation therapy.  It may also decrease the effectiveness of chemotherapy.

 

The authors of this report note that if the doctors make a point about cancer patients stopping smoking and provide services to help those patients, then between 25% to 70% of the patients will indeed quit.

 

In the current study, the researchers surveyed patients who had a variety of cancers either recently diagnosed and treated, or long term survivors who were diagnosed more than 10 years previously.  Most were white, and 85% had graduated from high school and 26% had some college education.

 

52% of the patients were either current or former smokers, and 39% of the patients were actively smoking when they were diagnosed with cancer.

 

44% of the patients were able to stop smoking after their diagnoses, while 56% continued to smoke.  Of the continuous smokers, 58% had thought of quitting smoking, while 42% had not.

 

One sad commentary in this study is that of the patients who were current smokers at the time of their cancer diagnosis, only 44% were advised by any member of their health care team that smoking was harmful to their treatment, and only 62% were told by their health care professionals that they should stop smoking.

 

So what do we take away from this study?

 

We know that smoking is harmful to your health.  But we also know it is even more harmful if you are being treated for cancer.

 

We know that one of the most important motivators in getting people to do something is if their health care professional tells them the importance of what they need to do.  You would think that having cancer would be one heck of a motivator to get someone to quit, but it obviously is not enough.  And if your doctor doesn’t talk to you about it and doesn’t offer you the opportunities to get help to quit, then that makes the situation even more difficult.  What you don’t know certainly can hurt you when it comes to smoking and cancer treatment.

 

For its part, the American Society of Clinical Oncology—which publishes the Journal of Oncology Practice—indicated in an article that appeared in the same issue as this study that cancer specialists could do more to address the issues of smoking cessation with their patients.  They pledged to increase awareness of this issue among their members, and to provide the information and resources to enable doctors and other health professionals to address their patients’ need to stop smoking.

 

The diagnosis of cancer and the rigors and side effects of the treatment are well-known to many of us.  Perhaps what is not as well known is that is sometimes the seemingly “small stuff” that can make a huge difference in the outcome of cancer treatment.  And, it isn’t “small stuff” when you survive your cancer yet continue to smoke, increasing your risk of another cancer years down the road.

 

When I was a younger physician in training we used to marvel at the patients with head and neck cancer who would continue smoking through a tracheotomy site, or other patients with end-stage lung cancer who would continue to smoke even as they were receiving intensive treatment.

 

And maybe those are simply situations where we would all end up leaving well enough alone.

 

But if you are a patient with a curable cancer, say colon or breast cancer, and you are undergoing surgery and/or radiation, then continuing to smoke could well cause severe complications if you get an infection or a bad reaction to the radiation treatment.

 

Maybe it’s time all of us paid more attention to the problem, and helped our patients and their families understand that even in these most difficult of circumstances, looking past the cigarettes just isn’t the right thing to do.

Filed Under:

Cancer Care | Tobacco | Treatment

Comments

1/25/2009 10:10:40 AM #

Gregory D. Pawelski

In an article, "Smoking, The Missing Drug Interaction in Clinical Trials: Ignoring the Obvious," Dr. Carolyn Dresler and her colleagues concluded that we can no longer ignore the obvious: smoking is a critical variable that affects cancer treatment and outcome and has been shown to vitiate or interact with the effects of some therapeutic agents and chemopreventive agents. Measurement of smoking history and status in clinical trials of cancer therapy will increase our knowledge of the adverse effects of the constituents of tobacco smoke, including nicotine, and of drug interactions.

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She makes the point that since ongoing smoking may significantly affect the outcome of subsequent surgery or therapy and negatively impact long-term survival, it is now the specialists' turn to provide the urgent smoking cessation treatment.

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No pharmaceutical trial ever followed whether patients smoked during their clinical trials, despite dosing themselves daily with cigarettes with hundreds chemicals in them. Dr. Dresler stated that "the addition of nicotine inhibits the ability of a chemo drug (like etoposide) to induce apoptosis by 61%." If a drug like nicotine, which occurs in the highest concentration of any drug in a cigarette, inhibits the ability of a major chemotherapy drug by 61%, a medical oncologist should care if it was being ingested during treatment.

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There are guidelines regarding smoking cessation techniques that have resulted from reviews of the world's literature and are very well accepted throughout the medical and psychological fields. However, "the biggest problem remains in having healthcare providers implement them routinely," Dr. Dresler says, "Most have emphasized the role of the primary healthcare provider in providing smoking cessation advice to patients, whereas the specialists, such as medical oncologists, radiation oncologists, thoracic surgeons or pulmonary care specialists should be dealing with the health problems resulting from the smoking as the patient faces imminent interventions such as radiation therapy, chemotherapy or surgery."

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Oncology health professionals have called for increased advocacy for tobacco control. Furthermore, the routine inclusion of smoking status and cessation need to become a standard of care for all patients. The inclusion of smoking data in oncology clinical trials will also provide clinicians with improved means of delivering individualized advice to patients with cancer that may be critical in motivating their cessation efforts and sustained abstinence.

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Scientific, financial, and clinical support is critical to this goal. The failure to date to assess, analyze, and report smoking status has limited our ability to investigate the effect of smoking on treatment efficacy and outcome. The time has come to integrate data about the single most important lifestyle risk factor in cancer prevention into cancer treatment and survivorship trials. (Cancer Epidemiol Biomarkers Prev 2005;14(10):2287-93)

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With the new Medicare Modernization Act (MMA), medical oncologists are reimbursed for providing evaluation and management services, making referrels, and offer any other support needed to reduce patient morbidity and extend patient survival. I certainly hope this would include smoking cessation guidance and support.

Gregory D. Pawelski

1/26/2009 4:10:27 PM #

Anna

I need to know why my mother has been in the hospital since the 13th of this month and the oncologist and the the other doc. only told my mother (ALL by herself in her room, when my father asked to be notified to be there for MY mother and the info!!!)of her cancer.Then it was in her lungs and liver. Today I find out it is throughout her body. Now they have not told my parents anything about what is going on. Why is that?? This hospital and the doctors should be held responsible for what is happening to my mother, which is NOTHING!!! I need to know why they are not informing my dad EVERYDAY. He is very upset with this Doctor,nurses and the hospital. They said they were going to transfer her LAST MONDAY and NOTHING. Please I need your help
Thank you and God Bless everyone
0ptomistic

Anna

1/28/2009 11:50:05 AM #

Gregory D. Pawelski

Unfortunately, I cannot disagree with a lot of what you say Anna. Many physicians have struggled with much of it most of their clinical life, as well as a lot of patients and their loved-ones. It is stunning and depressing.

Gregory D. Pawelski

9/30/2009 1:55:22 PM #

Sue

One year ago, when my mother was diagnosed with colon cancer I asked the doctor in private if he thought she should quit smoking (especially now). He told me that he could not talk to her about that since she was not diagnosed with LUNG cancer. Now after the first round of treatment she has 3 types of cancer including lung cancer. Maybe the doctor should have approached that differently, You think?

Sue

11/19/2009 2:12:51 PM #

Glenn

Congress doesn't even know what's in it, how can you? The final bill hasn't even been voted on (it keeps changing)! First there was the 'Smoking CONTROL act', NOW mammagrams and in-line is 'body fat'! Hummmmmmmmm???? BUT I am nearing the age of 'the back door' part of this 'great health bill'! I recently got back into the VA Health Care after being told there was a 18-24 mo. waiting list for the eighth time since serving during the VietNam era. AFTER the Walter Reed incident the waiting time came down to on average 90 days???? Hummmmm NOW I get to see a primary care DR. for 15 min every 6 mos. I was inlisted in medical treatment at VA clinic during 2003. After recently receiving a copy of my medical records from that facility, none of my diagnosis is what I was told affected me back in 2003. I quit smoking July 6, 2009 (cold turkey) after smoking 48 yrs. Reason taxes not by choice. A week later I had my first VA Clinic appointment since 2003. They had me go to VA Hopsital to take a breathing test. A month later and the findings showed a 'normal breathing capacity'. WOWWWWWWWWWWW ..... maybe someone's lying about the harm smoking causes! YET I have chronic fatigue daily? YOU who think this OBAMACARE health bill is so good, go visit VA hospitals, see the line, hear the stories from real veterans and patients to government health care! AND while your at it, ask them how a 48 year, 1 1/2-2 pack a day smoker has no lung or breathing problems? Since I cant pay rent the next 4 mos. to get me to the date I can collect my regular SS at age 62, maybe the cig manufacturers would be interested in paying me to do commericals contradicting the governments (false) campaign against smoking???? Guess like alot of VETS, I'll end up homeless along the road without cigarettes?

Glenn

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About Dr. Len

Dr. Len

J. Leonard Lichtenfeld, MD, MACP - Dr. Lichtenfeld is Deputy Chief Medical Officer for the national office of the American Cancer Society.

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