- How are brain and spinal cord tumors in adults treated?
- Surgery for adult brain and spinal cord tumors
- Radiation therapy for adult brain and spinal cord tumors
- Chemotherapy for adult brain and spinal cord tumors
- Targeted therapy for adult brain and spinal cord tumors
- Other drug treatments for adult brain and spinal cord tumors
- Treating specific types of adult brain and spinal cord tumors
Surgery for adult brain and spinal cord tumors
For brain and spinal cord tumors, surgery may be done for different reasons:
- To get a biopsy sample to determine the type of tumor
- To remove as much of the tumor as possible
- To help prevent or treat possible complications from the tumor
Before surgery, be sure you understand the goal of the surgery, as well as its possible benefits and risks.
Surgery to remove the tumor
In most cases, the first step in brain tumor treatment is for the neurosurgeon to remove as much of the tumor as is safe without affecting normal brain function.
Surgery alone or combined with radiation therapy may control or cure many tumors, including some low-grade astrocytomas, ependymomas, craniopharyngiomas, gangliogliomas, and meningiomas.
Tumors that tend to spread widely into nearby brain tissue such as anaplastic astrocytomas or glioblastomas cannot be cured by surgery. But surgery can reduce the amount of tumor that needs to be treated by radiation or chemotherapy, which might help these treatments work better. This could help prolong the person’s life even if all of the tumor can’t be removed.
Surgery may also help relieve some of the symptoms caused by brain tumors, particularly those caused by a buildup of pressure within the skull. These can include headaches, nausea, vomiting, and blurred vision. Surgery may also make seizures easier to control with medicines.
Surgery may not be a good option in some cases, such as if the tumor is deep within the brain, if it is in a part of the brain that can’t be removed, such as the brain stem, or if a person can’t have a major operation for other health reasons.
Surgery is not very effective against some types of brain tumors, such as lymphomas, although it may be used to get a biopsy for diagnosis.
Craniotomy: A craniotomy is a surgical opening made in the skull. This is the most common approach for surgery to treat brain tumors. The person may either be under general anesthesia (in a deep sleep) or may be awake for at least part of the procedure (with the surgical area numbed) if brain function needs to be assessed during the operation.
Part of the head might need to be shaved before surgery. The neurosurgeon first makes an incision in the scalp over the skull near the tumor, and the skin is folded back. A special type of drill is used to remove the piece of the skull over the tumor.
The opening is typically large enough for the surgeon to insert several instruments and view the parts of the brain needed to operate safely. The surgeon may need to make an incision into the brain itself to reach the tumor. The surgeon may use MRI or CT scans taken before the surgery (or may use ultrasound once the skull has been opened) to help locate the tumor and its edges.
The surgeon can remove the tumor in several ways depending on how hard or soft it is, and whether it has many or just a few blood vessels. One way is to cut it out with a scalpel or special scissors. Some tumors are soft and can be removed with suction devices. In other cases, a probe attached to an ultrasonic generator can be placed into the tumor to break it up and liquefy it. A small vacuum device is then used to suck it out.
Many devices can help the surgeon see the tumor and surrounding brain tissue. The surgeon often operates while looking at the brain through a special microscope. As mentioned above, MRI or CT scans can be done before surgery (or ultrasound can be used once the skull has been opened) to map the area of tumors deep in the brain. In some cases, the surgeon uses intraoperative imaging, in which MRI (or other) images are taken at different times during the operation to show the location of any remaining tumor. This may allow some brain tumors to be resected more safely and extensively.
As much of the tumor is removed as possible without affecting important brain tissue or leaving the patient disabled in any way. The surgeon can use different techniques to lower the risk of removing vital parts of the brain, such as:
- Intraoperative cortical stimulation: In this approach, the surgeon electrically stimulates parts of the brain in and around the tumor during the operation and monitors the response. This can show if these areas control an important function.
- Functional MRI: This type of imaging test (described in “How are adult brain and spinal cord tumors diagnosed?”) can be done before surgery to locate a particular function of the brain. This information can be used to identify and preserve that region during the operation.
Once the tumor is removed, the piece of the skull bone is put back in place and fastened with metal screws and plates, wires, or special stitches. (Usually any metal pieces are made from titanium, which allows a person to get follow-up MRIs.) You may have small tube (called a drain) coming out of the incision that allows excess cerebrospinal fluid (CSF) to leave the skull. Other drains may be in place to allow blood that builds up after surgery to drain from under the scalp. The drains are usually removed after a few days. An imaging test such as an MRI or CT scan is typically done 1 to 3 days after the operation to confirm how much of the tumor has been removed. Recovery time in the hospital is usually 4 to 6 days, although this depends on the size and location of the tumor, the patient’s general health, and whether other treatments are given. Healing around the surgery site usually takes several weeks.
Surgery to place a shunt or ventricular access catheter
If a tumor blocks the flow of the CSF, it can increase pressure inside the skull. This can cause symptoms like headaches, nausea, and drowsiness, and may even be life-threatening.
To drain excess CSF and lower the pressure, the neurosurgeon may put in a silicone tube called a shunt (sometimes referred to as a ventriculoperitoneal or VP shunt). One end of the shunt is placed in a ventricle of the brain (an area filled with CSF) and the other end is placed in the abdomen or, less often, the heart or other areas. The tube runs under the skin of the neck and chest. The flow of CSF is controlled by a valve placed along the tubing.
Shunts may be temporary or permanent. They can be placed before or after the surgery to remove the tumor. Placing a shunt normally takes about an hour. As with any operation, complications may develop, such as bleeding or infection. Sometimes shunts get clogged and need to be replaced. The hospital stay after shunt procedures is typically 1 to 3 days, depending on the reason it is placed and the patient’s general health.
Surgery may also be used to insert a ventricular access catheter, such as an Ommaya reservoir, to help deliver chemotherapy directly into the CSF. A small incision is made in the scalp, and a small hole is drilled in the skull. A flexible tube is then threaded through the hole until the open end of the tube is in a ventricle, where it reaches the CSF. The other end, which has a dome-shaped reservoir, stays just under the scalp. After the operation, doctors and nurses can use a thin needle to give chemotherapy drugs through the reservoir or to remove CSF from the ventricle for testing.
Possible risks and side effects of surgery
Surgery on the brain or spinal cord is a serious operation, and surgeons are very careful to try to limit any problems either during or after surgery. Complications during or after surgery such as bleeding, infections, or reactions to anesthesia are rare, but they can happen.
A major concern after surgery is swelling in the brain. Drugs called corticosteroids are typically given for several days after surgery to help lessen this risk.
One of the biggest concerns when removing brain tumors is the possible loss of brain function afterward, which is why doctors are very careful to remove only as much tissue as is safely possible. If problems do arise, it might be right after surgery, or it might be days or even weeks later, so close monitoring for any changes is very important (see the section “Recovering from the effects of the brain or spinal cord tumor and its treatment”).
For more information on surgery as a treatment for cancer, see our document Understanding Cancer Surgery: A Guide for Patients and Families.
Last Medical Review: 03/05/2014
Last Revised: 01/21/2016