- How is breast cancer in men treated?
- Surgery for breast cancer in men
- Radiation therapy for breast cancer in men
- Chemotherapy for breast cancer in men
- Hormone therapy for breast cancer in men
- Targeted therapy for breast cancer in men
- Bisphosphonates for breast cancer in men
- Denosumab for breast cancer in men
- Clinical trials for breast cancer in men
- Complementary and alternative therapies for breast cancer in men
- Treatment of breast cancer in men by stage
- More treatment information about breast cancer in men
- What should you ask your doctor about breast cancer in men?
Denosumab for breast cancer in men
A newer drug called denosumab (Xgeva®, Prolia®) is also now available to help lower the risk of fractures and other problems caused by breast cancer that has spread to the bone. It works differently from bisphosphonates. In studies of patients with breast cancer that had spread to the bone, it seemed to help prevent problems like fractures (breaks) better than zoledronic acid (Zometa). It also can help even after bisphosphonates stop working.
To treat cancer spread to bones, this drug is given as an injection under the skin every 4 weeks. Side effects include low blood levels of calcium and phosphate, as well as the jaw bone problem known as osteonecrosis of the jaw. This drug does not seem to affect the kidneys, so it is safe to give to patients with kidney problems.
Denosumab can also be used to make weak bones stronger in patients who are given treatments that lower androgen levels. This use has been studied in men being treated for prostate cancer, but it isn’t likely to be studied for this use in male breast cancer (since this disease is so rare). When given for this purpose, denosumab is given less often (usually every 6 months).
Last Medical Review: 09/21/2012
Last Revised: 02/26/2013