- Oncogenes, Tumor Suppressor Genes, and Cancer
- How do cells know what to do?
- What are mutations?
- Gene mutations that can lead to cancer
- How can oncogenes and tumor suppressor genes be used to help prevent cancer?
- How can oncogenes and tumor suppressor genes be used to help guide treatment of cancer?
- References
References
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American Cancer Society Cancer Information Database. Leukemia – Chronic Myeloid (Myelogenous). Accessed at http://www.cancer.org/Cancer/Leukemia-ChronicMyeloidCML/DetailedGuide/index on 12/13/2011.
American Cancer Society Cancer Information Database. Gastrointestinal Stromal Tumor (GIST). Accessed at http://www.cancer.org/Cancer/GastrointestinalStromalTumorGIST/DetailedGuide/index on 12/13/2011.
American Cancer Society Cancer Information Database. Stomach Cancer. Accessed at http://www.cancer.org/Cancer/StomachCancer/DetailedGuide/index on 12/13/2011.
Fearon ER, Bommer GT. Progressing from Gene Mutations to Cancer. In: Abeloff MD, Armitage JO, Lichter AS, Niederhuber JE. Kastan MB, McKenna WG. Clinical Oncology. 4th ed. Philadelphia, PA. Elsevier: 2008: 207-222.
Fong PC, Boss DS, Yap TA, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med. 2009 Jul 9;361(2):123-34.
Hawley AT, Pandolfi PP. Etiology of Cancer: Cancer Susceptibility Syndromes. In: DeVita VT, Hellman S, Rosenberg SA, eds. Cancer: Principles and Practice of Oncology. 7th ed. 2008; 157–168.
National Cancer Institute. Understanding Gene Testing. Accessed at http://www.cancer.gov/cancertopics/understandingcancer/genetesting on 12/13/2011. .
Ringer DP, Schniper LE. Principles of Cancer Biology. In: Lenhard RE, Osteen RT, Gansler T, eds. Clinical Oncology. Atlanta, GA: American Cancer Society; 2001: 25–30.
Tufts University School of Medicine, Department of Anatomy and Cellular Biology. The somatic mutation theory of cancer: growing problems with the paradigm? Bioessays. 2004; 26:1097–1107.
Last Medical Review: 12/27/2011
Last Revised: 12/27/2011
