HPV Vaccines

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Who should be vaccinated against HPV and when?

To work best, the HPV vaccine should be given before any type of sexual contact with another person. The vaccines are given as shots in a series of 3 doses within 6 months.

The American Cancer Society’s recommendations for each age group

Girls ages 11 to 12

The vaccine should be given to girls ages 11 to 12 and as early as age 9.

Girls ages 13 to 18

Girls ages 13 to 18 who have not yet started a vaccine series or who have started but have not completed the series should be vaccinated.

Young women ages 19 to 26

Some authorities recommend vaccination of women ages 19 to 26. The American Cancer Society feels that there is not enough evidence of benefit to recommend vaccinating all women in this age group. We do recommend that women ages 19 to 26 talk to their doctor or nurse about whether to get the vaccine. This decisions should be made after talking about their chance of previous HPV exposure and potential benefit from the vaccine.

Boys and young men

The American Cancer Society has no recommendation regarding the use of HPV vaccines in males. See the question below, “Can boys get the vaccine?”

Why do the vaccines have to be given at such a young age?

These vaccines will prevent the covered types of HPV only if they are given before exposure to the virus. According to the CDC, in 2011:

  • About half of girls in high school have had vaginal sex.
  • About 3% of high school students said they first had vaginal sex before age 13.

The vaccines are recommended for girls ages 11 to 12 because most girls at this age have not become sexually active. If they have been sexually active, most girls are likely have been exposed to only 1 or 2 types, so the vaccine will be partially protective. This is also an age when girls will still be seeing their doctors and getting other vaccinations.

What about women older than 26? Should they get one of the vaccines?

Women over age 26 were not included in the first studies that were done to test the vaccines. This means the FDA could not approve the vaccines for this age group. Since that time, the use of Gardasil in women between 27 and 45 has been studied. It was found that the vaccine helped protect against infection and disease from the HPV types contained in the vaccine. It only helped the women who weren’t infected with those HPV types before vaccination. Because the risk of infection and disease from HPV is low in this age group, the vaccine didn’t seem to benefit many women. When the FDA reviewed the data, it concluded that the vaccine didn’t help enough women to justify giving it to all women up to age 45.

Are there any girls or women who should not get one of the HPV vaccines or who should wait?

Yes. Anyone with a severe allergy to latex should not get the Cervarix vaccine, and those with a severe allergy to yeast should not receive Gardasil or Gardasil 9. These vaccines should also not be given to anyone who has ever had a life-threatening allergic reaction to anything else contained in them, or anyone who has had a serious reaction to an earlier dose of HPV vaccine. Tell the doctor if the girl getting the vaccine has any severe allergies.

Pregnant women should not get any HPV vaccine at this time. Even though they appear to be safe for both mother and the unborn baby, this is still being studied. If a woman who is pregnant does get an HPV vaccine, it’s not a reason to consider ending the pregnancy. Women who are breastfeeding may safely get either vaccine.

Any woman who finds out that she was pregnant when she got the vaccine is encouraged to call the Gardasil vaccine in pregnancy registry at 1-800-986-8999 or the Cervarix vaccine in pregnancy registry at 1-888-452-9622. Information from these registries will help doctors and scientists learn about pregnancy and infant outcomes after exposure to the vaccine. Women who started a vaccine series before they learned they were pregnant should complete the series after the pregnancy.

Can boys get the vaccine?

Yes. The FDA approved Gardasil and Gardasil 9 to protect boys from certain anal cancers and pre-cancers as well as to prevent anal and genital warts. These vaccine should be given before sexual activity begins, but are approved for different age ranges. Gardasil is approved for ages 9 to 26, while Gardasil 9 is approved for ages 9 to 15.

It’s not yet known if these vaccine will keep boys from passing HPV to their partners. If they do, this will also reduce the risk of HPV-linked cancers in their sexual partners.

In 2011, the Advisory Committee on Immunization Practices (ACIP) of the Centers for Disease Control and Prevention recommended that boys and young men receive the Gardasil vaccine routinely. The committee recommended that boys ages 11 and 12 be vaccinated. It also recommended vaccination of males ages 13 through 21 who had not already had all 3 shots. Vaccinations may also be given to boys as young as 9 and to men between the ages of 22 and 26. Gardasil 9 was not approved until late 2014, and so is not covered by these recommendations. ACIP is expected to release guidelines for Gardasil 9 in 2015.

The American Cancer Society has no recommendation about the use of any HPV vaccine in males at this time. The evidence for the use of HPV vaccines in males is being reviewed and updates to the American Cancer Society recommendations for the use of HPV vaccines will likely be published in 2015.

Do I need to be tested for HPV before getting the vaccine?

No. Testing is not needed and it’s not recommended. A positive HPV test result doesn’t always tell you which types of HPV are present. And even after infection with one type of HPV, the vaccine could still prevent other types of HPV infection. A negative test cannot tell you if you’ve had HPV in the past.

How long will the vaccines prevent HPV infection?

How long a new vaccine protects people is never known when the vaccine is first introduced. Current research (which includes about 6 years of follow-up data) shows that the vaccines are effective, and there’s no sign that the protection decreases with time. Research will continue to find out how long protection against HPV lasts, and if booster vaccines will be needed.


Last Medical Review: 04/09/2014
Last Revised: 12/12/2014