What Are the Key Statistics About Castleman Disease?

We don’t know how many people are diagnosed with Castleman disease (CD) each year. The National Cancer Institute keeps track of how many people have each type of cancer, but because CD is not a cancer it is not included. We do know that CD is rare, especially in people who are otherwise healthy.

The localized (unicentric) form of CD is more common than the multicentric form (MCD). MCD is much more likely to occur in people infected with HIV. Over the past few decades, as the number of people with HIV infection has increased, the number of people diagnosed with MCD has also gone up. Modern anti-viral treatments have helped people with HIV live much longer, but these drugs don’t seem to lower the chance of getting MCD.

CD can affect children as well as adults. Younger people are more likely to have the localized form. Older adults and those with HIV infection are more likely to have the multicentric form.

For statistics related to survival, see the section “ Outlook (prognosis) for people with Castleman disease.”

The American Cancer Society medical and editorial content team
Our team is made up of doctors and master’s-prepared nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.

Last Medical Review: July 7, 2014 Last Revised: May 23, 2016

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