- Surgery for Castleman disease
- Radiation therapy for Castleman disease
- Corticosteroids for Castleman disease
- Chemotherapy for Castleman disease
- Immunotherapy for Castleman disease
- Antiviral drugs for Castleman disease
- Clinical trials for Castleman disease
- Complementary and alternative therapies for Castleman disease
- Treatment of localized (unicentric) Castleman disease
- Treatment of multicentric Castleman disease
Treatment of localized (unicentric) Castleman disease
Surgery is the recommended treatment for people with localized Castleman disease (CD) whenever possible. Removing the abnormal lymph node(s) usually cures the disease. Symptoms such as fever and fatigue that are caused by the CD go away when the lymph node is removed. Relapses are rare. Radiation can also cure localized disease but it’s not used as often.
Some patients with localized CD develop secondary amyloidosis, a condition in which abnormal proteins build up in the kidneys, skin, and some other organs. This protein build-up stops once the lymph node affected by CD is removed.
The outlook for localized CD is very good if the affected lymph node(s) can be removed with surgery. But sometimes the surgeon cannot safely remove all the disease. This doesn't necessarily mean it will come back. Even partial removal may help, and the disease may not grow back.
Last Medical Review: 06/11/2012
Last Revised: 04/24/2014