- What is cancer?
- What is cervical cancer?
- What are the key statistics about cervical cancer?
- What are the risk factors for cervical cancer?
- Do we know what causes cervical cancer?
- Can cervical cancer be prevented?
- Can cervical cancer be found early?
- Signs and symptoms of cervical cancer
- How is cervical cancer diagnosed?
- How is cervical cancer staged?
- Survival rates for cervical cancer, by stage
- How is cervical cancer treated?
- Surgery for cervical cancer
- Radiation therapy for cervical cancer
- Chemotherapy for cervical cancer
- Targeted therapy for cervical cancer
- Clinical trials for cervical cancer
- Complementary and alternative therapies for cervical cancer
- Treatment options for cervical cancer, by stage
- More treatment information
- What should you ask your doctor about cervical cancer?
- What happens after treatment for cervical cancer?
- Lifestyle changes after having cervical cancer
- How is your emotional health affected by having cervical cancer?
- If treatment for cervical cancer stops working
- What`s new in cervical cancer research and treatment?
- Additional resources for cervical cancer
- References: Cervical cancer detailed guide
Do we know what causes cervical cancer?
In recent years, scientists have made much progress toward understanding what happens in cells of the cervix when cancer develops. In addition, they have identified several risk factors that increase the odds that a woman might develop cervical cancer (see the previous section).
The development of normal human cells mostly depends on the information contained in the cells’ chromosomes. Chromosomes are large molecules of DNA. DNA is the chemical that carries the instructions for nearly everything our cells do. We usually look like our parents because they are the source of our DNA. However, DNA affects more than the way we look.
Some genes (packets of our DNA) have instructions for controlling when our cells grow and divide. Certain genes that promote cell division are called oncogenes. Others that slow down cell division or cause cells to die at the right time are called tumor suppressor genes. Cancers can be caused by DNA mutations (gene defects) that turn on oncogenes or turn off tumor suppressor genes.
HPV causes the production of 2 proteins known as E6 and E7 which turn off some tumor suppressor genes. This may allow the cervical lining cells to grow too much and to develop changes in additional genes, which in some cases will lead to cancer.
But HPV does not completely explain what causes cervical cancer. Most women with HPV don’t get cervical cancer, and certain other risk factors, like smoking and HIV infection, influence which women exposed to HPV are more likely to develop cervical cancer.
Last Medical Review: 09/19/2014
Last Revised: 10/13/2014