- What is cervical cancer?
- What are the risk factors for cervical cancer?
- Can cervical cancer be prevented?
- The American Cancer Society guidelines for the prevention and early detection of cervical cancer
- The HPV DNA test
- The Pap test
- Work-up of abnormal Pap test results
- Cervical cancer prevention and screening: Financial issues
- Additional resources
Adam E, Kaufman RH, Adler-Storthz K, et al. A prospective study of association of herpes simplex virus and human papillomavirus infection with cervical neoplasia in women exposed to diethylstilbestrol in utero. Int J Cancer. 1985;35(1):19−26.
American Cancer Society. Cancer Facts & Figures 2016. Atlanta, Ga: American Cancer Society; 2016.
American Cancer Society. Cancer Prevention & Early Detection Facts & Figures 2015-2016. Atlanta, Ga: American Cancer Society; 2015.
American Cancer Society. Detailed Guide: Cervical Cancer. Accessed at www.cancer.org/Cancer/CervicalCancer/DetailedGuide/index on December 2016.
Anderson TA, Schick V, Herbenick D, Dodge B, Fortenberry JD. A study of human papillomavirus on vaginally inserted sex toys, before and after cleaning, among women who have sex with women and men. Sex Transm Infect. 2014 Apr 16. [Epub ahead of print]
Ault KA, Future II study group. Effect of prophylactic human papillomavirus L1 virus-like-particle vaccine on risk of cervical intraepithelial neoplasia grade 2, grade 3, and adenocarcinoma in situ: a combined analysis of four randomised clinical trials. Lancet. 2007;369(9576):1861−1868.
Castellsagué X, Bosch FX, Muñoz N, Meijer CJ, et al. Male circumcision, penile human papilloma virus infection, and cervical cancer in female partners. N Engl J Med. 2002; 346(15):1105−1112.
Centers for Disease Control and Prevention (CDC). Use of 9-Valent Human Papillomavirus (HPV) Vaccine: Updated HPV Vaccination Recommendations of the Advisory Committee on Immunization Practices. MMWR Morb Mortal Wkly Rep. 2015 March 27;64(11):300−304.
Ghosh C, Baker JA, Moysich KB, et al. Dietary intakes of selected nutrients and food groups and risk of cervical cancer. Nutr Cancer. 2008;60(3):331−341.
Gray RH, Serwadda D, Kong X, Makumbi F, et al. Male circumcision decreases acquisition and increases clearance of high-risk human papillomavirus in HIV-negative men: A randomized trial in Rakai, Uganda. J Infect Dis. 2010;201(10):1455−1462.
Hatch EE, Herbst AL, Hoover RN, et al. Incidence of squamous neoplasia of the cervix and vagina in women exposed prenatally to diethylstilbestrol (United States). Cancer Causes Control. 2001;12(9):837−845.
Hernandez BY, Wilkens LR, Zhu X, et al. Transmission of human papillomavirus in heterosexual couples. Emerg Infect Dis. 2008;14(6):888−894.
Hogewoning CJ, Bleeker MC, van den Brule AJ, et al. Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus: A randomized clinical trial. Int J Cancer. 2003;107(5):811−816.
International Collaboration of Epidemiological Studies of Cervical Cancer. Appleby P, Beral V, Berrington de González A, et al. Cervical cancer and hormonal contraceptives: Collaborative reanalysis of individual data for 16,573 women with cervical cancer and 35,509 women without cervical cancer from 24 epidemiological studies. Lancet. 2007;370(9599):1609−1621.
Jhingran A, Russel AH, Seiden MV, et al. Cancers of the cervix, vagina and vulva. In: Abeloff MD, Armitage JO, Lichter AS, et al. Clinical Oncology. 5th ed. Philadelphia, Pa; Elsevier; 2014: 1534-1574.
Lacey JV Jr, Swanson CA, Brinton LA, et al. Obesity as a potential risk factor for adenocarcinomas and squamous cell carcinomas of the uterine cervix. Cancer. 2003;98(4):814−821.
Lu B, Wu Y, Nielson CM, et al. Factors associated with acquisition and clearance of human papillomavirus infection in a cohort of US men: a prospective study. J Infect Dis. 2009;199(3):362−371.
Klopp AH, Eifel PJ, Berek JS, Konstantinopoulos PA. Chapter 72: Cancer of the cervix, vagina, and vulva. In: DeVita VT, Hellman S, Rosenberg SA, eds. Cancer: Principles and Practice of Oncology 10th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2015.
Marrazzo JM, Koutsky LA, Stine KL, et al. Genital human papillomavirus infection in women who have sex with women. J Infect Dis. 1998;178(6):1604−1609.
Massad LS, Einstein MH, Huh WK, et al. 2012 Updated Consensus Guidelines for the Management of Abnormal Cervical Cancer Screening Tests and Cancer Precursors. Journal of Lower Genital Tract Disease. 2013;17(5): S1-S27.
Medicare.gov. Pap tests and pelvic exams. Accessed at www.medicare.gov/coverage/pap-tests-pelvic-exams-screening.html on November 21, 2016.
National Institutes of Health. Medline Plus. Female Condoms. 04/05/2016. Accessed at https://medlineplus.gov/ency/article/004002.htm on November 21, 2016.
Nielson CM, Harris RB, Flores R, et al. Multiple-type human papillomavirus infection in male anogenital sites: Prevalence and associated factors. Cancer Epidemiol Biomarkers Prev. 2009;18(4):1077−1083.
Ronco G, Cuzick J, Pierotti P, et al. Accuracy of liquid based versus conventional cytology: Overall results of new technologies for cervical cancer screening: Randomised controlled trial. BMJ. 2007;335(7609):28.
Saslow D, Andrews KS, Manassaram-Baptiste D, et al. Human papillomavirus vaccination guideline update: American Cancer Society guideline endorsement. CA Cancer J Clin. 2016.
Saslow D, Solomon D, Lawson H, et al. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. CA Cancer J Clin. 2012;62(3):147-172.
Schiffman M, Castle PE, Jeronimo J, et al. Human papillomavirus and cervical cancer. Lancet. 2007;370(9590):890−907.
Solomon D, Davey D, Kurman R, et al; Bethesda 2001 Workshop. The 2001 Bethesda System: Terminology for reporting results of cervical cytology. JAMA. 2002;287:2114−2119.
Tobian AA, Serwadda D, Quinn TC, Kigozi G, et al. Male circumcision for the prevention of HSV-2 and HPV infections and syphilis. N Engl J Med. 2009;360(13):1298−1309.
Tokudome S, Suzuki S, Ichikawa H, et al. Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus: A randomized clinical trial. Int J Cancer. 2004;112(1).
Troisi R, Hatch EE, Titus-Ernstoff L, et al. Cancer risk in women prenatally exposed to diethylstilbestrol. Int J Cancer. 2007;121(2):356−360.
Warner K. Huh, Kevin A. Ault, David Chelmow, et al. Use of Primary High-Risk Human Papillomavirus Testing for Cervical Cancer Screening: Interim Clinical Guidance. J Lower Gen Tract Dis. 2015;19: 91–96.
Winer RL, Hughes JP, Feng Q, et al. Condom use and the risk of genital human papillomavirus infection in young women. N Engl J Med. 2006;354:2645−2654.
Winer RL, Lee SK, Hughes JP, et al. Genital human papillomavirus infection: incidence and risk factors in a cohort of female university students. Am J Epidemiol. 2003;157(3):218-226. Erratum in: Am J Epidemiol. 2003;157(9):858.
Last Medical Review: 11/20/2016
Last Revised: 12/08/2016