Most cases of endometrial cancer cannot be prevented, but there are some things that may lower your risk of developing this disease.
Get to and stay at a healthy weight
One way to lower endometrial cancer risk is to do what you can to change your risk factors whenever possible. For example, women who are overweight or obese have up to 3½ times the risk of getting endometrial cancer compared with women at a healthy weight. Getting to and maintaining a healthy weight is one way to lower the risk of this cancer.
Be physically active
Studies have also linked higher levels of physical activity to lower risks of endometrial cancer, so engaging in regular physical activity (exercise) may also be a way to help lower endometrial cancer risk. An active lifestyle can help you stay at a healthy weight, as well as lower the risk of high blood pressure and diabetes (other risk factors for endometrial cancer.
Discuss pros and cons of hormone therapy with your doctor
Estrogen to treat the symptoms of menopause is available in many different forms like pills, skin patches, shots, creams, and vaginal rings. If you are thinking about using estrogen for menopausal symptoms, ask your doctor about how it will affect your risk of endometrial cancer. Progestins (progesterone-like drugs) can reduce the risk of endometrial cancer in women taking estrogen therapy, but this combination increases the risk of breast cancer. If you still have your uterus and are taking estrogen therapy, discuss this issue with your doctor.
Get treated for endometrial problems
Getting proper treatment of pre-cancerous disorders of the endometrium is another way to lower the risk of endometrial cancer. Most endometrial cancers develop over a period of years. Many are known to follow and possibly start from less serious abnormalities of the endometrium called endometrial hyperplasia (see “Endometrial cancer risk factors”). Some cases of hyperplasia will go away without treatment, but it sometimes needs to be treated with hormones or even surgery. Treatment with progestins (see “Hormone therapy for endometrial cancer”) and a dilation and curettage (D&C) or hysterectomy can prevent hyperplasia from becoming cancerous. (D&C is described in “Tests for endometrial cancer ”) Abnormal vaginal bleeding is the most common symptom of endometrial pre-cancers and cancers, and it needs to be reported and evaluated right away.
Talk to your doctor if you have HNPCC
Women with hereditary nonpolyposis colon cancer (HNPCC or Lynch syndrome) have a very high risk of endometrial cancer. A woman with HNPCC may choose to have her uterus removed (a hysterectomy) after she has finished having children to prevent endometrial cancer. One study found that none of 61 women with HNPCC who had prophylactic (preventive) hysterectomies was later found to have endometrial cancer, while 1/3 of the women who didn't have the surgery were diagnosed with endometrial cancer over the next 7 years.
Last Revised: 02/29/2016