Ewing Family of Tumors

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What`s New in Ewing Family Of Tumors Research? TOPICS

What’s new in Ewing tumor research and treatment?

Research on Ewing tumors is being done at many medical centers, university hospitals, and other institutions across the world.

Diagnosis

Scientists are developing new techniques to more accurately diagnose Ewing tumors. New lab tests of tumor samples (see the section “How are Ewing tumors diagnosed?”) are being studied to see if they can help identify Ewing tumors and give more information on how well specific treatments might cure that particular tumor.

Treatment

Researchers are looking to develop better treatments for Ewing tumors, as well as to find less toxic treatments for those that can be cured.

Chemotherapy

The Children’s Oncology Group, individual universities, and children’s hospitals are studying new chemotherapy combinations, which often include newer drugs such as topotecan, irinotecan, temozolomide, gemcitabine, docetaxel, trabectedin, and mithramycin (plicamycin).

Doctors are also trying to make the currently used drugs more effective by changing the way they are given. For example, they have found that giving the standard VAC/IE chemo regimen more often – that is, every 2 weeks instead of every 3 weeks – seems to lower the chance of localized Ewing tumors coming back, without increasing the risk of serious side effects. This is often called compressed chemotherapy.

Researchers are also studying high-dose chemotherapy with stem cell transplants in those with Ewing tumors that are unlikely to be cured with current treatments.

Targeted therapy

As noted in the section “Do we know what causes Ewing tumors?”, great progress is being made in understanding the changes in genes and chromosomes that cause Ewing tumors to form.

This knowledge has already been used to develop very sensitive lab tests to detect this cancer, and doctors are now studying how to best use these tests to guide the choice of treatment. It might also lead to new drugs that target these changes in Ewing tumor cells.

Some new drugs that target specific changes in Ewing tumor cells are already being tested. For example, drugs that target the insulin-like growth factor receptor-1 (IGF-1R), a protein on some cancer cells that causes them to grow, are now being studied in clinical trials. Early studies have found that these drugs can shrink some Ewing tumors and slow down the growth of others. So far, this benefit has been temporary in most cases. Researchers continue to study these drugs and ways to combine them with other targeted drugs.

Other newer drugs being studied for use against Ewing tumors include:

  • Drugs that affect a tumor’s ability to make new blood vessels, such as bevacizumab (Avastin)
  • Drugs that target the mTOR protein, such as temsirolimus (Torisel) and everolimus (Afinitor)

Last Medical Review: 06/12/2013
Last Revised: 06/12/2013