Ewing Family of Tumors

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References: Ewing family of tumors detailed guide

American Cancer Society. Cancer Facts & Figures 2013. Atlanta, Ga: American Cancer Society; 2013.

American Joint Committee on Cancer. Bone. AJCC Cancer Staging Manual. 7th ed. New York: Springer-Verlag; 2010: 281–287.

Bacci G, Longhi A, Barbieri E, et al. Second malignancy in 597 patients with Ewing sarcoma of bone treated at a single institution with adjuvant and neoadjuvant chemotherapy between 1972 and 1999. J Pediatr Hematol Oncol. 2005;27:517–520.

Bernstein M, Kovar H, Paulussen M, et al. Ewing’s sarcoma family of tumors: Current management. Oncologist. 2006;11:503–519.

Dome JS, Rodriguez-Galindo C, Spunt SL, Santana VM. Pediatric solid tumors: Ewing’s sarcoma family tumors. In: Abeloff MD, Armitage JO, Niederhuber JE. Kastan MB, McKenna WG, eds. Abeloff’s Clinical Oncology. 4th ed. Philadelphia, Pa: Elsevier; 2008:2085–2091.

Gebhardt MC, Springfield D, Neff JR. Sarcomas of bone: Ewing’s sarcoma. In: Abeloff MD, Armitage JO, Niederhuber JE. Kastan MB, McKenna WG, eds. Abeloff’s Clinical Oncology. 4th ed. Philadelphia, Pa: Elsevier; 2008:1982–1994.

Gorlick R, Janeway K, Lessnick S, Randall RL, Marina N; COG Bone Tumor Committee. Children’s Oncology Group’s 2013 blueprint for research: Bone tumors. Pediatr Blood Cancer. 2013;60:1009–1015.

Grier HE, Krailo MD, Tarbell NJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. New Engl J Med. 2003; 348:694–701.

Hawkins DS, Bolling T, Dubois S, et al. Ewing sarcoma. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. 6th ed. Philadelphia Pa: Lippincott Williams & Wilkins; 2011:987–1014.

Kolb EA, Kushner BH, Gorlick R, et al. Long-term event-free survival after intensive chemotherapy for Ewing’s family of tumors in children and young adults. J Clin Oncol. 2003;21:3423–3430.

Lee J, Hoang BH, Ziogas A, Zell JA. Analysis of prognostic factors in Ewing sarcoma using a population-based cancer registry. Cancer. 2010;116:1964–1973.

Miser JS, Krailo MD, Tarbell NJ, et al. Treatment of metastatic Ewing’s sarcoma or primitive neuroectodermal tumor of bone: Evaluation of combination ifosfamide and etoposide – A Children’s Cancer Group and Pediatric Oncology Group study. J Clin Oncol. 2004;22:2873–2876.

Miser JS, Goldsby RE, Chen Z, et al. Treatment of metastatic Ewing sarcoma/primitive neuroectodermal tumor of bone: Evaluation of increasing the dose intensity of chemotherapy — A report from the Children’s Oncology Group. Pediatr Blood Cancer. 2007;49:894–900.

Naing A, LoRusso P, Fu S, et al. Insulin growth factor-receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with refractory Ewing’s sarcoma family tumors. Clin Cancer Res. 2012;18:2625–2631.

National Cancer Institute. Physician Data Query (PDQ). Ewing Sarcoma Treatment. 2012. Accessed at www.cancer.gov/cancertopics/pdq/treatment/ewings/healthprofessional on April 10, 2013.

National Comprehensive Cancer Network (NCCN). Practice Guidelines in Oncology: Bone Cancer. Version 2.2013. Accessed at www.nccn.org/professionals/physician_gls/pdf/bone.pdf on April 10, 2013.

Rodriguez-Galindo C. Pharmacological management of Ewing sarcoma family of tumours. Expert Opin Pharmacother. 2004;5:1257–1270.

Rodriguez-Galindo C, Liu T, Krasin MJ, et al. Analysis of prognostic factors in Ewing sarcoma family of tumors: Review of St. Jude Children’s Research Hospital studies. Cancer. 2007;110:375–384.

Russell HV, Pappo AS, Nuchtern JG, et al. Solid tumors of childhood: Ewing’s sarcoma. In: DeVita VT, Lawrence TS, Rosenberg SA, eds. DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology. 8th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2008:2061–2067.

Subbiah V, Anderson P. Targeted therapy of Ewing’s sarcoma. Sarcoma. 2011;2011:686985. Epub 2010 Oct 31.

Toomey EC, Schiffman JD, Lessnick SL. Recent advances in the molecular pathogenesis of Ewing’s sarcoma. Oncogene. 2010;29:4504–4516.

Womer RB, West DC, Krailo MD, et al. Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: A report from the Children’s Oncology Group. J Clin Oncol. 2012;30:4148–4154.


Last Medical Review: 06/12/2013
Last Revised: 06/12/2013