- How is gallbladder cancer treated?
- Surgery for gallbladder cancer
- Radiation therapy for gallbladder cancer
- Chemotherapy for gallbladder cancer
- Palliative therapy for gallbladder cancer
- Clinical trials for gallbladder cancer
- Complementary and alternative therapies for gallbladder cancer
- Treatment options based on the extent of gallbladder cancer
- More treatment information about gallbladder cancer
Surgery for gallbladder cancer
There are 2 general types of surgical treatment for cancer of the gallbladder: potentially curative surgery and palliative surgery.
Potentially curative surgery is done when imaging tests or the results of earlier surgeries show there is a good chance that the surgeon will be able to remove all of the cancer. Doctors may use the term resectable to describe cancers they believe can be removed completely by surgery and unresectable to describe those that have spread too far or are in too difficult a place to be entirely removed by surgery. Unfortunately, only a small portion of gallbladder cancers are resectable when they are first found.
Palliative surgery may be done to relieve pain or prevent complications, such as blockage of the bile ducts, if the tumor is too widespread to be completely removed. Palliative surgery is not expected to cure the cancer, but it can sometimes help relieve symptoms and/or prolong a person's life. Palliative surgery is described in more detail in the section, "Palliative therapy for gallbladder cancer."
Surgery to remove gallbladder cancer can have significant side effects and, depending on how extensive it is, may require several weeks for recovery. Patients whose cancer is not curable may want to carefully weigh the pros and cons of surgery or treatments that require significant recovery time. It is very important to understand the goal of any surgery for gallbladder cancer, what the possible benefits and risks are, and how the surgery is likely to affect your quality of life.
Often, when gallbladder cancer is suspected, the surgeon will do a laparoscopy before any other surgery. This is done to help determine the extent of the cancer and whether it may be resectable or not. Laparoscopy may let the surgeon see areas of cancer that were not detected with imaging tests.
In this procedure, a small cut is made so that a long, lighted tube called a laparoscope can be inserted into the abdomen. The doctor uses the laparoscope to look around the abdominal cavity for signs of cancer spread. If the cancer is resectable, laparoscopy can also help in planning the operation to remove it.
Cholecystectomy (simple cholecystectomy)
The operation to remove the gallbladder is called a cholecystectomy. If only the gallbladder is removed, the operation may be called simple cholecystectomy.
This operation is often used to remove the gallbladder for other reasons such as gallstones, but it is not done if gallbladder cancer is known or suspected (a more extensive operation is done instead).
Gallbladder cancers are sometimes found incidentally (by accident) after a person has a cholecystectomy for another reason, such as gallstones. If the cancer is found to be at a very early stage (T1a) and is thought to have been completely removed, no further surgery may be needed. If there's a chance the cancer may have spread beyond the gallbladder, more extensive surgery may be advised.
A simple cholecystectomy can be done in 2 ways:
Laparoscopic cholecystectomy: This is the most common way to remove a gallbladder for non-cancerous problems, such as gallstones. This method uses a laparoscope, a thin, flexible tube with a tiny video camera on the end that is inserted through a small cut in the skin of the patient's abdomen. Long surgical tools are placed through several other small openings to remove the gallbladder.
Laparoscopic surgery tends to be easier for patients because of the smaller incision size. But this type of operation is not used if gallbladder cancer is suspected. This surgery offers the surgeon only a limited view of the area around the gallbladder, so there is a greater chance that some cancer might be missed and left behind. It may also lead to the accidental spread of the cancer to other parts the body.
Open cholecystectomy: In this approach, the surgeon removes the gallbladder through a large incision (cut) in the abdominal wall. This method is sometimes used if a non-cancerous gallbladder problem is suspected (such as gallstones), which in some cases may lead to the discovery of gallbladder cancer. But if gallbladder cancer is suspected before surgery, doctors prefer to do an extended cholecystectomy.
Extended (radical) cholecystectomy
Because of the risk that the cancer will come back if just the gallbladder is removed, a more extensive operation, known as an extended (or radical) cholecystectomy, is done in most cases of gallbladder cancer. This can be an involved, complex operation, and it is best done by a surgeon who is experienced in treating gallbladder cancer.
The extent of the surgery depends on where the cancer is located and how far it might have spread. At a minimum, an extended cholecystectomy removes:
- The gallbladder
- About an inch or more of liver tissue next to the gallbladder
- All of the lymph nodes in the region
If the surgeon feels it is needed and the patient is healthy enough, the operation may also include one or more of the following:
- Removing more of the liver, ranging from a wedge-shaped section of the liver close to the gallbladder (wedge resection) to a whole lobe of the liver (hepatic lobectomy)
- Removing the common bile duct
- Removing part or all of the ligament that runs between the liver and the intestines
- Removing lymph nodes around the pancreas, around the major blood vessels leading to the liver (the portal vein and hepatic artery), and around the artery that brings blood to most of the small intestine and to the pancreas
- Removing the pancreas
- Removing the duodenum (the first part of the small intestine into which the bile duct drains)
- Removing any other areas of organs to which cancer has spread
Possible risks and side effects
The risks and side effects of surgery depend in large part on how much tissue is removed and a person's general health before the surgery. All surgery carries some risk, including the possibility of bleeding, infections, complications from anesthesia, and pneumonia.
Laparoscopic cholecystectomy is the least invasive operation and tends to have fewer side effects. Most people will have at least some pain from the incisions for a few days after the operation, although this can usually be controlled with medicines if needed. The incision is larger for an open cholecystectomy, so there is usually more pain and a longer recovery time.
Extended cholecystectomy is a major operation that may involve removing parts of several organs. This can have a significant effect on a person's recovery and health after the surgery. Because most of the organs are involved in digestion, eating problems may be a concern for some time after surgery. Your doctor or nurse will discuss the possible side effects with you in more detail before your surgery.
For more general information about surgery, please see our document, Surgery.
Last Medical Review: 04/30/2012
Last Revised: 01/18/2013