Leukemia--Acute Lymphocytic Overview

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What Is Leukemia - Acute Lymphocytic (ALL) in Adults? TOPICS

What is acute lymphocytic leukemia?

Leukemia is a type of cancer that starts in cells that form new blood cells. These cells are found in the soft, inner part of the bones called the bone marrow.

Normal bone marrow, blood, and lymphoid tissue

To understand the different types of leukemia, it helps to know something about the blood and lymph systems. Any blood-forming cell can turn into a leukemia cell. Once that happens, the cell can grow and divide to form many new cancer cells. These cells can take over the bone marrow, spill out into the bloodstream, and spread to other organs.

Bone marrow

Bone marrow is the soft, spongy, inner part of bones such as the skull, shoulder blades, ribs, pelvis, and bones in the spine. All of the different types of blood cells are made in the bone marrow. Bone marrow is made up of a small number of blood stem cells, blood-forming cells, fat cells, and tissues that help the blood cells grow.

Blood stem cells go through a series of changes to make new blood cells. They can develop into 1 of the 3 main types of blood cell:

  • Red blood cells
  • White blood cells
  • Platelets

Red blood cells

Red blood cells carry oxygen from the lungs to all other tissues of the body. They also carry away carbon dioxide, a waste product of cell activity.

White blood cells

White blood cells help the body fight infections. There are quite a few types of white blood cells. Each has a special role to play in protecting the body against infection. The 3 main types of white blood cells are granulocytes, monocytes, and lymphocytes.

Lymphocytes are the main cells that make up lymphoid tissue, which is a major part of the immune system. The 2 main types of lymphocytes are called B cells and T cells. Normal T cells and B cells do different jobs within the immune system. ALL starts in early forms of B cells or T cells.

Platelets

Platelets help stop bleeding by plugging up holes in blood vessels caused by cuts or bruises.

Acute lymphocytic leukemia

Acute lymphocytic leukemia (ALL) is also called acute lymphoblastic leukemia. The term acute means that the leukemia grows quickly, and if not treated, could be fatal in a few months. People with chronic leukemias can live years without treatment. Lymphocytic means it develops from early forms of lymphocytes, a type of white blood cell. This is different from acute myeloid leukemia (AML), which starts in other blood cell types found in the bone marrow. To learn about AML, please see our document, Leukemia--Acute Myeloid.

Other types of cancer that start in lymphocytes are known as lymphomas (non-Hodgkin lymphoma and Hodgkin disease). The main difference between these types of cancers is that the cancer cells in ALL are mainly in the bone marrow and blood (although they may spread to other places), while lymphomas are mainly in lymph nodes or other organs. For more information on lymphomas, see our documents, Non-Hodgkin Lymphoma and Hodgkin Disease.

After it starts, leukemia often moves quickly into the blood where it can spread to other parts of the body such as the lymph nodes, spleen, liver, central nervous system (brain and spinal cord), and other organs. In contrast, other types of cancer can start in these organs and then spread to the bone marrow (or elsewhere). Those cancers are not leukemia. Both children and adults can get leukemia.

ALL isn’t the only kind of leukemia. There are 4 main types of leukemia:

Knowing the exact type can help doctors better predict each patient's outlook (prognosis) and select the best treatment.

The rest of this document contains information on ALL of adults only. Chronic leukemias of adults and acute myeloid leukemia (AML) of adults are discussed in other American Cancer Society documents. For information about ALL in children, please see the separate document, Childhood Leukemia.


Last Medical Review: 06/25/2013
Last Revised: 02/07/2014