- How is childhood leukemia treated?
- Immediate treatment for childhood leukemia
- Surgery for childhood leukemia
- Radiation therapy for childhood leukemia
- Chemotherapy for childhood leukemia
- Targeted therapy for childhood leukemia
- High-dose chemotherapy and stem cell transplant for childhood leukemia
- Clinical trials for childhood leukemia
- Complementary and alternative therapies for childhood leukemia
- Treatment of children with acute lymphocytic leukemia (ALL)
- Treatment of children with acute myelogenous leukemia (AML)
- Treatment of children with acute promyelocytic leukemia (APL)
- Treatment of children with juvenile myelomonocytic leukemia (JMML)
- Treatment of children with chronic myelogenous leukemia (CML)
Targeted therapy for childhood leukemia
In recent years, new drugs that target specific parts of cancer cells have been developed. These targeted drugs work differently from standard chemotherapy drugs. They sometimes work when chemo drugs don’t, and they often have different (and less severe) side effects. Some of these drugs can be useful in certain childhood leukemias.
For instance, nearly all children with chronic myeloid leukemia (CML) have an abnormal chromosome in their leukemia cells known as the Philadelphia chromosome. Targeted drugs such as imatinib (Gleevec) and dasatinib (Sprycel) specifically attack cells that have this chromosome. These drugs are very effective at controlling the leukemia for long periods of time in most of these children, although it’s not yet clear if the drugs can help cure CML.
A small number of children with acute lymphocytic leukemia (ALL) also have the Philadelphia chromosome in their leukemia cells. Studies have shown that their outcome is improved when these drugs are given along with chemotherapy drugs.
These drugs are taken daily as pills. Possible side effects include diarrhea, nausea, muscle pain, fatigue, and skin rashes. These are generally mild. A common side effect is swelling around the eyes or in the hands or feet. Some studies suggest this fluid buildup may be caused by the drugs’ effects on the heart. Other possible side effects include lower red blood cell and platelet counts at the start of treatment. These drugs might also slow a child’s growth, especially if used before puberty.
Other targeted drugs are now being tested in clinical trials as well.
For more general information on targeted drugs, see Targeted Therapy.
Last Medical Review: 04/17/2015
Last Revised: 04/17/2015