Childhood Leukemia Overview

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What Is Leukemia in Children? TOPICS

What is childhood leukemia?

Leukemia is a cancer that starts in early blood-forming cells. Most of the time, it is a cancer of the white blood cells, but some leukemias start in other kinds of blood cells. Leukemia starts in the bone marrow, the soft inner part of certain bones where new blood cells are made, and quickly spreads to the blood. From there it can go to other parts of the body.

In contrast, some other types of childhood cancer, such as Wilms tumor (a kidney cancer), can start in other organs and then spread to the bone marrow (or elsewhere). But those cancers are not leukemia.

Normal bone marrow, blood, and lymphoid tissue

To understand the different types of leukemia, it helps to know something about the blood and lymph systems.

Bone marrow

Bone marrow is the soft, spongy, inner part of bones. It is where new blood cells are made. In babies, new blood cells are made in nearly all of the bones of the body. But by the teenage years they are made mostly in the flat bones such as those of the skull, shoulder blades, ribs, pelvis, and back bones.

Bone marrow is made up of a small number of blood-forming cells (blood stem cells), other early forms of blood cells, fat cells, and tissues that help the blood cells grow. Early blood cells can grow to become red blood cells, white blood cells, or platelets.

Red blood cells

Red blood cells carry oxygen from the lungs to all other tissues of the body and take carbon dioxide back to the lungs to be removed.

Platelets

Platelets are actually pieces that break off from certain bone marrow cells. Platelets help stop bleeding by plugging holes in blood vessels caused by cuts or bruises.

White blood cells

White blood cells help defend the body against germs. There are quite a few types (and subtypes) of white blood cells. Each has a special role to play in protecting the body against infection. The 3 main types of white blood cells are lymphocytes, granulocytes, and monocytes.

  • Lymphocytes: These are the main cells that make up lymphoid tissue, a major part of the immune system. The immune system helps the body fight off infections. The 2 main types of lymphocytes are B lymphocytes (B cells) and T lymphocytes (T cells). Acute lymphocytic (lymphoblastic) leukemia (ALL), the most common type of childhood leukemia, starts from early forms of lymphocytes. Although both can develop into leukemia, B-cell ALL is much more common than T-cell ALL.
  • Granulocytes: The main job of these white blood cells is to destroy germs. Granulocytes go through several changes as they grow from early cells to mature, infection-fighting cells.
  • Monocytes: Monocytes also help protect the body against germs. After a short time in the bloodstream, they enter tissues to become macrophages, which can destroy some germs by surrounding and “eating” them.

Types of leukemia in children

Leukemia can be either fast growing (acute), or slower growing (chronic). Almost all leukemia in children is acute.

Acute leukemias

There are 2 main types of acute leukemia:

  • Acute lymphocytic leukemia (ALL), also called acute lymphoblastic leukemia, accounts for about 3 out of 4 cases of childhood leukemia. This leukemia starts from early forms of lymphocytes in the bone marrow.
  • Acute myelogenous leukemia (AML), also called acute myeloid leukemia, accounts for most of the remaining cases. This leukemia starts from the cells that form white blood cells (other than lymphocytes), red blood cells, or platelets.

Hybrid or mixed lineage leukemias are rare. The cells have features of both ALL and AML. In children they are most often treated like ALL and respond to treatment like ALL.

Chronic leukemias

Chronic leukemia is also divided into 2 types:

  • Chronic myeloid leukemia (CML) is rare in children.
  • Chronic lymphocytic leukemia (CLL) is almost never seen in children and is not covered here.

Juvenile myelomonocytic leukemia (JMML)

This rare type of leukemia is neither chronic nor acute. It isn’t as fast growing as AML or as slow as CML. It occurs most often in children under age 4. Symptoms can include pale skin, fever, cough, easy bruising or bleeding, trouble breathing (from too many white blood cells in the lungs), and a swollen spleen and lymph nodes.


Last Medical Review: 11/11/2013
Last Revised: 02/03/2014