What’s new in malignant mesothelioma research and treatment?
There is always research going on in the area of mesothelioma. Scientists are looking for better ways to prevent, diagnose, and treat mesothelioma. Despite recent progress, much remains to be learned about the best way to treat these cancers.
Causes and prevention
Some research is focused on learning exactly how asbestos changes mesothelial cells and their DNA to cause these cancers. Understanding how these fibers produce cancer might help us develop ways to prevent those changes.
The role of asbestos in increasing the risk of mesothelioma is a definite public health concern. Researchers are learning more about which asbestos fibers can cause cancer, how they cause it, and what levels of exposure might be considered safe. Now that the dangers of asbestos are known, we can limit or stop exposure in homes, public buildings, and the workplace. Unfortunately, regulations protecting workers from asbestos exposure are much less stringent in some countries than in others.
Research is also under way to clarify the role (if any) of SV40, a virus that has been linked to mesothelioma in some studies.
Mesothelioma remains a difficult cancer to treat, and doctors are constantly trying to improve on current approaches. The exact roles of surgery, radiation therapy, and chemotherapy in the treatment of mesothelioma are still being studied. Combinations of these treatments are now being tested and may provide the most promising option for some patients. Newer types of treatment now being studied may give patients and their doctors even more options.
Some chemotherapy drugs can shrink or slow the growth of mesotheliomas, but in most cases the effects last for a limited time. Studies are underway to test newer chemotherapy drugs.
Another technique now being studied is photodynamic therapy (PDT). For this treatment, a light-activated drug is injected into a vein. The drug spreads throughout the body and tends to collect in cancer cells. A few days later (usually in the operating room, just after surgery), a special red light on the end of a tube is placed into the chest. The light causes a chemical change that activates the drug and kills the cancer cells. Since the drug is only active in the areas exposed to the special light, this approach might cause fewer side effects than using drugs that spread throughout the body. Several clinical trials are now studying the use of PDT for mesothelioma. To find out more about PDT, see Photodynamic Therapy.
In general, chemo drugs have a limited effect against mesothelioma. As researchers have learned more about the changes in cells that cause cancer, they have developed newer drugs that target these changes. Targeted drugs work differently from standard chemo drugs. They sometimes work when chemo drugs don’t, and they often have different (and less severe) side effects.
Sunitinib (Sutent) is an example of a targeted drug that has shown promise in some studies.
Other new drugs have different targets. For example, some new drugs target mesothelin, a protein found in high levels in mesothelioma cells. To learn more about targeted therapy drugs, see Targeted Therapy.
Other newer forms of treatment
Because standard treatments often have limited usefulness against mesothelioma, researchers are studying other new types of treatment as well.
Gene therapy: A newer type of treatment being tested on mesothelioma is gene therapy, which attempts to add new genes to cancer cells to make them easier to kill. One approach to gene therapy uses special viruses that have been modified in the lab. The virus is injected into the pleural space and infects the mesothelioma cells. When this infection occurs, the virus injects the desired gene into the cells. In one version of this approach, the virus carries a gene that helps turn on the immune system to attack the cancer cells. Early studies of this approach have found it may shrink or slow the growth of mesothelioma in some people, but more research is needed to confirm this.
Immunotherapy: Other new treatments called cancer vaccines are also aimed at getting the immune system to attack the cancer. In one approach, immune cells are removed from a patient’s blood and treated in the lab to get them to react to tumor cells. The immune cells are then given back to the patient as blood transfusions, where it is hoped they will cause the body’s immune system to attack the cancer. This approach is now being studied in clinical trials.
Another form of immunotherapy being studied is a drug called tremelimumab, which targets a certain immune cells and takes the brakes off the immune system.
To learn more, see Cancer Immunotherapy.
Virus therapies: Researchers are also studying the use of specially designed viruses to treat mesothelioma. These viruses can be put into the pleural space, where the hope is that they can either infect and kill the cancer cells directly, or cause the immune system to attack the cancer cells. These approaches are still in the early phases of clinical trials.
Last Medical Review: 05/18/2015
Last Revised: 02/17/2016