Immunotherapy for neuroblastoma

Monoclonal antibodies are man-made versions of immune system proteins that can be made to attack a very specific target. These molecules can be injected into the body to seek out and attach to cancer cells to help treat some cancers.

A monoclonal antibody called ch14.18 attaches to the ganglioside GD2, a substance found on the surface of many neuroblastoma cells. This antibody can be given together with cytokines (immune system hormones) such as GM-CSF and interleukin-2 (IL-2) to help the child’s immune system to recognize and destroy neuroblastoma cells. This antibody is now part of the routine treatment for many children with high-risk neuroblastoma, often after a stem cell transplant.

Possible side effects

Side effects of ch.14.18 may include nerve pain (which can be severe), leaking of fluid in the body (which can lead to low blood pressure, fast heart rate, shortness of breath, and swelling), and allergic reactions.