- Pancreatic cancer treatment
- Surgery for pancreatic cancer
- Ablation or embolization treatments for pancreatic cancer
- Radiation therapy for pancreatic cancer
- Chemotherapy and other drugs for pancreatic cancer
- Drugs used to treat pancreatic neuroendocrine tumors
- Pain control in pancreatic cancer
- Treating pancreatic cancer, based on extent of the cancer
- Treating pancreatic neuroendocrine tumors, based on extent of the tumor
Surgery for pancreatic cancer
Two general types of surgery can be used for pancreatic cancer:
- Potentially curative surgery is used when the results of exams and tests suggest that it’s possible to remove (resect) all the cancer.
- Palliative surgery may be done if imaging tests show that the cancer is too widespread to be removed completely. This surgery is done to relieve symptoms or to prevent certain complications like a blocked bile duct or intestine, but the goal is not to try to cure the cancer.
To determine which type of surgery might be best, it’s important to know the stage (extent) of the cancer. But it can be hard to stage pancreatic cancer accurately just using imaging tests. Sometimes laparoscopy is done first to help determine the extent of the cancer and if it can be resected.
For this procedure, the surgeon makes a few small incisions (cuts) in the abdomen and inserts long, thin instruments. One of these has a small video camera on the end so the surgeon can see inside the abdomen. The surgeon can look at the pancreas and other organs for tumors and take biopsy samples of abnormal areas to learn how far the cancer has spread.
Potentially curative surgery
Studies have shown that removing only part of a pancreatic cancer doesn’t help patients live longer, so potentially curative surgery is only done if the surgeon thinks all of the cancer can be removed.
This is very complex surgery, and it can also be very hard for patients. It can cause complications and can take weeks to months to recover from. If you are thinking about having this type of surgery, it’s important to weigh the potential benefits and risks carefully.
Fewer than 1 in 5 pancreatic cancers appear to be confined to the pancreas at the time they are found. Even then, not all of these cancers turn out to be truly resectable once the surgery is started. Sometimes once the surgeon starts the operation it becomes clear that the cancer has grown too far to be removed completely. If this happens, the operation may be stopped, or the surgeon might continue with a smaller operation with a goal of relieving or preventing symptoms (see “Palliative surgery”). This is because the planned operation would be very unlikely to cure the cancer and could still lead to major side effects. It would also lengthen the recovery time, which could delay other treatments.
Surgery offers the only realistic chance to cure exocrine pancreatic cancer, but it doesn’t always lead to a cure. Even if all visible cancer is removed, often some cancer cells have already spread to other parts of the body. These cells can eventually grow into new tumors, which can be very hard to treat.
Long-term success rates for surgery on pancreatic neuroendocrine tumors (NETs) are often much better. These tumors are more likely to be cured with surgery.
Curative surgery is done mainly to treat cancers in the head of the pancreas. Because these cancers are near the bile duct, they often cause jaundice, which sometimes allows them to be found early enough to be removed. Surgeries for other parts of the pancreas are mentioned below, but these are only done when it’s possible to remove all of the cancer.
Three procedures can be used to remove tumors of the pancreas:
Whipple procedure (pancreaticoduodenectomy)
This is the most common operation to remove a cancer of the exocrine pancreas. It also sometimes is used to treat pancreatic NETs.
During this operation, the surgeon removes the head of the pancreas and sometimes the body of the pancreas as well. Nearby structures such as part of the small intestine, part of the bile duct, the gallbladder, lymph nodes near the pancreas, and sometimes part of the stomach are also removed. The remaining bile duct and pancreas are then attached to the small intestine so that bile and digestive enzymes can still enter the small intestine. The pieces of the small intestine (or the stomach and small intestine) are then reattached as well so that food can pass through the digestive tract.
Most often, this operation is done through a large incision (cut) down the middle of the belly. Some doctors at major cancer centers also do the operation laparoscopically, which is sometimes known as keyhole surgery (see What’s new in pancreatic cancer research?).
A Whipple procedure is a complex operation that requires a surgeon with a lot of skill and experience. It carries a relatively high risk of complications that can sometimes be life threatening. When the operation is done in small hospitals or by doctors with less experience, as many as 15% of patients may die as a result of surgical complications. In contrast, when the operation is done in cancer centers by surgeons experienced in the procedure, less than 5% of patients die as a direct result of surgery.
To have the best outcome, it’s important to be treated by a surgeon who does many of these operations and to have the surgery at a hospital where many of them are done. In general, people having this type of surgery do better when it is at a hospital that does at least 15 to 20 Whipple procedures per year.
Still, even under the best circumstances, many patients have complications from the surgery. These can include:
- Leaking from the various connections among organs that the surgeon has to make
- Trouble with the stomach emptying itself after eating
- Trouble digesting some foods (which might require taking pancreatic enzymes in pill form to help with digestion)
- Weight loss
- Changes in bowel habits
In this operation, the surgeon removes only the tail of the pancreas or the tail and a portion of the body of the pancreas. The spleen is usually removed as well. This operation is used more often to treat pancreatic NETs found in the tail and body of the pancreas. It is seldom used to treat cancers of the exocrine pancreas because these tumors have usually already spread by the time they are found.
The spleen helps the body fight infections, so if it’s removed you’ll be at increased risk of infection with certain bacteria. To help with this, doctors recommend that patients get certain vaccines before this surgery.
This operation removes the entire pancreas, as well as the gallbladder, part of the stomach and small intestine, and the spleen. This surgery might be an option if the cancer has spread throughout the pancreas but can still be removed. But this type of surgery is used less often than the other operations because there doesn’t seem to be a major advantage in removing the whole pancreas, and it can have major side effects.
It’s possible to live without a pancreas. But when the entire pancreas is removed, people are left without the cells that make insulin and other hormones that help maintain blood sugar levels. These people develop diabetes, which can be hard to manage because they are totally dependent on insulin shots. People who have had this surgery also need to take pancreatic enzyme pills to help them digest certain foods.
Before you have this operation, your doctor will recommend that you get certain vaccines because the spleen will be removed.
If the cancer has spread too far to be removed completely, any surgery being considered would be palliative (intended to relieve or prevent symptoms). Because pancreatic cancer can progress quickly, most doctors don’t advise major surgery for palliation, especially for people who are in poor health.
Sometimes surgery might be started with the hope it will cure the patient, but once it begins the surgeon discovers this is not possible. In this case, the surgeon might do a less extensive, palliative operation known as bypass surgery instead to help prevent or relieve symptoms.
Cancers growing in the head of the pancreas can block the common bile duct as it passes through this part of the pancreas. This can cause pain and digestive problems because bile can’t get into the intestine. The bile chemicals will also build up in the body, which can cause jaundice, nausea, vomiting, and other problems.
There are 2 main options for relieving bile duct blockage.
The most common approach to relieving a blocked bile duct does not involve actual surgery. Instead, a stent (small tube, usually made of metal) is placed inside the duct to keep it open. This is usually done through an endoscope (a long, flexible tube) while you are sedated. Often this is part of an endoscopic retrograde cholangiopancreatography (ERCP). The doctor passes the endoscope down the throat and all the way into the small intestine. The doctor can then insert the stent into the bile duct through the endoscope. The stent can also be put in place through the skin during a percutaneous transhepatic cholangiography (PTC). (These tests are described in Tests for pancreatic cancer.)
The stent helps keep the bile duct open even if the surrounding cancer presses on it. But after several months, the stent may become clogged and may need to be cleared or replaced. Larger stents can also be used to keep parts of the small intestine open if they are in danger of being blocked by the cancer.
A bile duct stent can also be put in to help relieve jaundice before curative surgery is done (which would typically be a couple of weeks later). This can help lower the risk of complications from surgery.
In people who are healthy enough, another option for relieving a blocked bile duct is surgery to reroute the flow of bile from the common bile duct directly into the small intestine, bypassing the pancreas. This typically requires a large incision in the abdomen, and it can take weeks to recover from this. Sometimes surgery can be done through several small cuts in the abdomen using special long surgical tools. (This is known as laparoscopic or keyhole surgery.)
Having a stent placed is often easier and the recovery is much shorter, which is why this is done more often than bypass surgery. But surgery can have some advantages, such as:
- It can often give longer-lasting relief than a stent, which might need to be cleaned out or replaced.
- It might be an option if a stent can’t be placed for some reason.
- During surgery, the surgeon may be able to cut some of the nerves around the pancreas or inject them with alcohol. This may reduce or get rid of any pain caused by the cancer. (Pancreatic cancer often causes pain if it reaches these nerves.)
Sometimes, the end of the stomach is disconnected from the duodenum (the first part of the small intestine) and attached farther down the small intestine during this surgery as well. (This is known as a gastric bypass.) This is done because over time the cancer might grow large enough to block the duodenum, which can cause pain and vomiting and often requires urgent surgery. Bypassing the duodenum before this happens can sometimes help avoid this.
Bypass surgery can still be a major operation, so it’s important that you are healthy enough to withstand it and that you talk with your doctor about the possible benefits and risks before you have the surgery.
Surgery to treat pancreatic neuroendocrine tumors
Along with the operations described above, sometimes a less extensive procedure can be used to remove pancreatic NETs.
Enucleation (removing just the tumor)
Sometimes if a pancreatic NET is small, just the tumor itself is removed. This is called enucleation. This operation may be done using a laparoscope, so that only a few small incisions are needed.
This operation may be all that is needed to treat an insulinoma, since this type of tumor is often benign. Small gastrinomas and some other pancreatic NETs may also be treated with enucleation, but sometimes the duodenum (the first part of the small intestine) is removed as well.
The lymph nodes around the pancreas might also be removed so that they can be checked for cancer cells.
Whipple procedure or distal pancreatectomy
For larger gastrinomas and other types of pancreatic NETs, a pancreaticoduodenectomy (Whipple procedure) or a distal pancreatectomy is often needed, depending on the location of the tumor. These operations are described above.
The lymph nodes around the pancreas are often removed as well so that they can be checked for cancer cells.
Surgery for cancer that has spread
Surgery may be used to remove metastases if a pancreatic NET has spread to the liver (the most common site of spread) or the lungs. Removing metastases can improve symptoms and prolong life in patients with pancreatic NETs. In rare cases, a liver transplant might be used to treat pancreatic NETs that have spread to the liver.
For more about surgery as a treatment for cancer, see the website section on Surgery Used to Treat Cancer.
Last Medical Review: 03/14/2016
Last Revised: 04/05/2016