Retinoblastoma

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Early Detection, Diagnosis, and Staging TOPICS

Signs and symptoms of retinoblastoma

Retinoblastomas are often found when a parent or doctor notices a child’s eye looks unusual.

White pupillary reflex

This is the most common early sign of retinoblastoma. Normally when you shine a light in the eye, the pupil (the dark spot in the center of the eye) looks red because of the blood in vessels in the back of the eye. In an eye with retinoblastoma, the pupil often appears white or pink instead, which is known as a white pupillary reflex (or leukocoria).

This white glare of the eye may be noticed by a parent after a flash photograph is taken, especially if the pupils are different colors. It also might be noted by the child’s doctor during a routine eye exam.

Lazy eye

Sometimes the eyes do not appear to look in the same direction, a condition often called lazy eye. (Doctors call this strabismus.) There are many possible causes of this in children. Most of the time lazy eye is caused by a mild weakness of the muscles that control the eyes, but retinoblastoma is also one of the rare causes.

Other possible signs and symptoms

Less common signs and symptoms of retinoblastoma include:

  • Vision problems
  • Eye pain
  • Redness of the white part of the eye
  • Bleeding in the front part of the eye
  • Bulging of the eye
  • A pupil that does not get smaller when exposed to bright light
  • A different color in each iris (the colored part of the eye)

Many of these signs and symptoms are more likely to be caused by something other than retinoblastoma. Still, if your child has any of these, check with your child’s doctor so that the cause can be found and treated, if needed.


Last Medical Review: 12/05/2013
Last Revised: 12/05/2013