Melanoma Skin Cancer Overview

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Causes, Risk Factors, and Prevention TOPICS

What are the risk factors for melanoma skin cancer?

We do not yet know exactly what causes melanoma skin cancer. But we do know that certain risk factors are linked to this disease. A risk factor is anything that affects your chance of getting a disease. Different cancers have different risk factors. Some risk factors, like smoking, can be changed. Others, like a person’s age or family history, can’t be changed.

But having a risk factor, or even several risk factors, does not mean that you will get the disease. And some people who get the disease may have few or no known risk factors. Even if a person with melanoma has a risk factor, it’s often very hard to know what part that risk factor may have played in getting the cancer.

Scientists have found several risk factors that could make a person more likely to get melanoma.

UV (ultraviolet) light

Too much exposure to UV rays is a major risk factor for most melanomas. The main source of UV rays is the sun. Tanning lamps and beds are also sources of UV rays. People with high levels of UV exposure from these sources are at greater risk for all types of skin cancer.

The amount of UV exposure a person gets depends on the strength of the light, how long the skin is exposed, and whether the skin is covered with clothing or sunscreen.

To find out more about how to protect yourself and your family, see the section “Can melanoma skin cancer be prevented?


A mole (the medical name is nevus) is a benign (not cancer) skin tumor. The chance of any single mole turning into cancer is very low. But certain types of moles increase a person’s chance of getting melanoma.

People who have many abnormal moles are more likely to develop melanoma. These people should have very thorough skin exams by a skin doctor (dermatologist). Many doctors also suggest these people should be shown how check their own skin every month. Good sun protection is always important.

Light-colored skin, freckles, and light hair

The risk of melanoma is more than 10 times higher for whites than for African Americans. Whites with red or blond hair, blue or green eyes, or fair skin that freckles or burns easily are at increased risk.

Family history of melanoma

Your risk of melanoma is higher if you have a close relative (parent, brother, sister, or child) who has had the disease. This could be because the family tends to spend more time in the sun, or because the family members have fair skin, or both. It may also be because of a gene change (mutation) that runs in the family.

People with a strong family history of melanoma should do these things:

  • Have regular skin exams by a skin doctor (dermatologist)
  • Look closely at their own skin once a month and report any changes to the doctor
  • Be very careful about sun exposure and avoid tanning beds

(To find out more, see “Can melanoma skin cancer be prevented?”)

Having had melanoma in the past

A person who has already had melanoma has a higher risk of getting another one.

Weak immune system

People who have been treated with medicines that suppress the immune system, such as organ transplant patients, have an increased risk of melanoma.


Melanoma is more likely to happen in older people. But it is a cancer that is also found in younger people. In fact, it is one of the most common cancers in people under 30.


In the United States, melanoma is generally more common in men than in women. But this varies by age. Before age 40, the risk is higher for women; after age 40 the risk is higher in men.

Xeroderma pigmentosum (XP)

This is a rare, inherited condition. People with XP are less able to repair damage caused by sunlight and are at greater risk of melanoma and other skin cancers at a young age.

Last Medical Review: 02/19/2014
Last Revised: 09/16/2014