Testicular Cancer Overview

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Treating Testicular Cancer TOPICS

Chemotherapy for testicular cancer

Chemotherapy (chemo) is the use of drugs to treat cancer. The drugs can be taken in pill form or through a needle into a vein or muscle. Once the drugs enter the bloodstream, they spread throughout the body. Chemo is a good way to destroy any cancer cells that break off from the main tumor and travel to lymph nodes or distant organs. It is often used to cure testicular cancer when it has spread outside the testicle or to decrease the risk of cancer coming back after the testicle is removed.

Doctors give chemo in cycles, with each round of treatment followed by a rest period to allow the body time to recover. Chemo cycles often last about 3 to 4 weeks. Using 2 or more chemo drugs together often works better than using one drug alone.

Side effects

The side effects of chemo depend on the type of drugs given, the amount taken, and how long the treatment lasts. Side effects could include:

  • Hair loss (hair grows back after treatment)
  • Mouth sores
  • Loss of appetite
  • Nausea and vomiting
  • Increased chance of infection
  • Easy bruising or bleeding
  • Tiredness

If you have side effects, your doctor or nurse can suggest steps to ease them. For instance, there are drugs to help control and prevent nausea and vomiting. The good news is that most side effects will go away when your treatment ends. You should report any side effects or changes you notice while getting chemo to your doctor so that you can get prompt treatment for them.

Some of the drugs used to treat testicular cancer can have side effects other than those mentioned above. Most side effects are short-term and go away after treatment is finished, but some can last a long time and may never go away completely. These can include:

  • Kidney or bladder damage
  • Nerve damage (which can cause numbness and tingling)
  • Hearing loss (from nerve damage)
  • Lung damage (which can cause shortness of breath and reduce your ability to exercise)
  • Heart problems

Getting a second cancer (usually leukemia) is another very serious, but rare, side effect. It happens in less than 1% of testicular cancer patients treated with chemo.

For more about chemo and its side effects, please see our document, A Guide to Chemotherapy. If you’d like more information on a drug used in your treatment, see our Guide to Cancer Drugs, ask a member of your health care team, or call us with the names of the medicines you’re taking.


Last Medical Review: 01/02/2014
Last Revised: 02/11/2014