Tests for Thymus Cancer

If there is a reason to think you might have a thymus tumor, your doctor will ask you about symptoms and use one or more exams or tests to check for one. Certain signs and symptoms might suggest that a person may have a thymus tumor, but tests are needed to know for sure.

Medical history and physical exam

If you have signs or symptoms that suggest you might have a thymus tumor, your doctor will want to take a complete medical history to check for symptoms. You will also be asked about your general health.

A physical exam provides information about possible signs of thymic cancer and other health problems. Patients with thymic cancer will sometimes have a fullness that the doctor can feel in the lower neck area.

Thymomas are often suspected if you have signs and symptoms associated with myasthenia gravis, hypogammaglobulinemia, or red cell aplasia .

Imaging tests

Imaging tests use x-rays, magnetic fields, or radioactive substances to create pictures of the inside of your body. Imaging tests may be done for a number of reasons, including:

• To help find a suspicious area that might be cancer
• To learn how far cancer may have spread
• To help see if treatment is working
• To look for signs that cancer has come back

Chest x-ray

A chest x-ray may be the first imaging test a doctor orders if they suspect a problem in the middle of the chest. It may be able to show if there is a tumor in the chest. In some cases, a chest x-ray may find tumors when the person is having the x-ray done for another reason. But some thymomas are small or in places that may not show up on a chest x-ray. If your doctor is still suspicious or if a change is seen on the chest x-ray, a CT scan may be ordered.

Computed tomography (CT) scan

A CT scan uses x-rays to make detailed, cross-sectional images of your body. Unlike a regular x-ray, a CT scan creates detailed images of the soft tissues in the body. A chest CT with contrast is often used.

CT scans can also be used to guide a biopsy needle precisely into a suspected tumor or metastasis. This is called a CT-guided needle biopsy.

Magnetic resonance imaging (MRI) scan

Like CT scans, MRI scans provide detailed images of soft tissues in the body. But MRI scans use radio waves and strong magnets instead of x-rays.

MRI of the chest may be done to look more closely at thymus tumors. They are most often used for people who cannot have a CT scan for medical reasons (like problems with the IV contrast). MRI images are also particularly useful in looking for cancer that may have spread to the brain or spinal cord.

Positron emission tomography (PET) scan

For a PET scan, you are injected with a slightly radioactive form of sugar, which collects mainly in cancer cells. A special camera is then used to create a picture of areas of radioactivity in the body. The picture is not detailed like a CT or MRI scan, but a PET scan can look for possible areas of cancer spread in all areas of the body at once.

A PET scan can help give the doctor a better idea of whether a change seen on another imaging test is a tumor or not. If you have already been diagnosed with cancer, your doctor may use this test to see if the cancer has spread to lymph nodes or other parts of the body. A PET scan can also be useful if your doctor thinks the cancer may have spread but doesn’t know where.

Certain machines are able to perform both a PET and CT scan at the same time (PET/CT scan). This lets the doctor compare areas of higher radioactivity on the PET scan with the more detailed pictures of that area on the CT. Combined PET/CT is used more often than PET (alone) in looking at thymomas.

Blood tests

Blood tests can’t be used to diagnose thymomas, but they may be helpful in some situations. For example, blood tests may be done to look for certain antibodies if myasthenia gravis (MG) or another autoimmune disorder is suspected. Other blood tests might be done to make sure a mass in the middle of the chest isn’t a germ cell tumor or part of the thyroid gland.

If a thymoma is diagnosed, blood cell counts and blood chemistry tests are done to get an idea of a person’s overall health, especially if surgery is planned. Also, tests for myasthenia gravis will be done before any surgery. This is because MG is very common in people with a thymoma, and, if not treated, it can cause problems with the drugs used during surgery. People getting chemotherapy need regular blood tests to make sure the drugs aren’t having unwanted effects on the bone marrow, kidneys, or other organs.

Biopsy procedures

Although signs, symptoms, and imaging tests can suggest that a thymic tumor is likely, doctors can’t be certain of the diagnosis without looking at the tumor under a microscope.

For most cancers, taking out a small piece of the tumor (known as a biopsy) is needed to confirm whether a tumor is present and, if so, to determine its type. For thymomas, this is rarely done because doctors can usually tell that the tumor is very likely a thymoma based on how it looks on imaging tests. Because of this, doctors often remove the entire tumor rather than do a biopsy. This provides tissue for a diagnosis and treats the tumor at the same time. The specimen is sent to the lab after surgery to confirm the diagnosis. See Surgery For Thymus Cancer for more information.

If the tumor can't be removed completely during surgery, a biopsy might be done to confirm the diagnosis. This helps the doctor decide if more treatment is needed after surgery.

If the doctor suspects a different type of tumor, a biopsy (usually a needle biopsy) might be done before surgery.

See Testing Biopsy and Cytology Specimens for Cancer to learn more about the types of biopsies, how the tissue is used in the lab to diagnose cancer, and what the results may show.