• If you are allergic to any medicines, dyes, additives, or foods.

• If you have a history of congestive heart failure or are taking a diuretic (water pill).

• This drug may cause you to retain fluids, which could make some existing conditions worse.

• If you have a history of heart disease or stroke. This drug can cause heart problems, such as abnormal heartbeats, in some people. In rare cases this has been linked to strokes.

• If you have a history of kidney disease. This drug is cleared from the body mainly by the kidneys. Reduced kidney function might result in more drug than expected staying in the body, which could lead to unwanted side effects. Your doctor may need to adjust your dose accordingly.

• If you have any type of eye condition. This drug can cause eye problems in some people, including blurring or loss of vision.

• If you have any other medical conditions such as liver disease (including hepatitis), lung disease, diabetes, gout, or infections. You may need closer monitoring of these conditions while being treated, or the drug dose, regimen, or timing may need to be changed.

• If you are pregnant, trying to get pregnant, or if there is any chance of pregnancy. It is not known if this drug might cause problems if either the male or female is taking it at the time of conception or during pregnancy. Men and women who are taking this drug should use some kind of birth control during treatment. It is important to check with your doctor about what kinds of birth control can be used with this medicine. This drug should be used during pregnancy only if the potential benefit is thought to justify the potential risk to the fetus.

• If you are breast-feeding. While no studies have been done, this drug may pass into breast milk and affect the baby. Talk with your doctor about the possible risks of breast-feeding while taking this drug.

• About any other prescription or over-the-counter medicines you are taking, including vitamins and herbs.

The dose will depend on your weight and how well your kidneys are working. The dose and/or schedule may need to be adjusted depending on how your body responds to treatment.

This drug can be given in a doctor’s office, or you or a family member can learn how to give the shot at home.

If you are taking it at home, make sure to keep the medicine in its original container in the refrigerator, and keep the shot equipment in a safe place out of reach of children and pets. Keep used needles in a closed needle bucket and bring them back to your doctor or nurse.

This drug should not be used after high-dose chemotherapy for a bone marrow transplant or peripheral blood stem cell transplant.

Your doctor will test your blood frequently throughout your treatment, looking for possible effects of the drug on blood counts or on blood chemistry levels. Based on the test results, your doctor may need to reduce or delay your next dose of this drug, or even stop it altogether.

This drug can cause the body to retain fluid. This can lead to swelling (edema) in the hands or feet, or fluid buildup in the lungs or abdomen. Tell your doctor or nurse if you notice any swelling or sudden weight gain, or if you begin to have shortness of breath or a new onset of cough.

This drug can cause changes in heart rhythms in some people. Most often this involves a rapid heartbeat, but it may include other abnormal rhythms. In rare cases this has led to strokes. Tell your doctor or nurse right away if you feel your heart is pounding or may be skipping beats, if you notice chest pain or shortness of breath, or if you feel dizzy or lightheaded.

In rare cases, this drug can cause swelling of the optic nerve (which connects the eye to the brain), a condition known as papilledema. This can lead to blurred vision or even blindness. Tell your doctor or nurse right away if you notice any changes in vision.

In rare cases, this drug can cause allergic reactions when the drug is given. Mild reactions may consist of fever, chills, skin itching, or feeling flushed. More serious reactions happen rarely, but can be dangerous. Symptoms can include feeling lightheaded or dizzy (due to low blood pressure), chest tightness, shortness of breath, back pain, or swelling of the face, tongue, or throat. Tell your doctor or nurse right away if you notice any of these symptoms during or after being given the drug.

A rare but serious side effect is capillary leak syndrome, in which the small blood vessels in the body become leaky. This can allow fluid to leave the bloodstream and enter other parts of the body. This results in low blood pressure, fluid buildup, and poor blood flow to the internal organs. Tell your doctor right away if you feel dizzy or notice sudden swelling or rapid weight gain, trouble breathing, abnormal heart beats, chest pain, or little or no urine output.

• fluid buildup (can lead to swelling in the hands or feet, or fluid in the chest or abdomen)
• shortness of breath

• feeling weak or tired
• rapid heart rate or palpitations*
• feeling dizzy or faint
• redness in the eyes
• runny nose
• skin rash or itching
• headache
• fever
• trouble sleeping

• injection site reaction (redness, pain, or swelling)
• vision changes*
• sores or white patches in the mouth
• diarrhea
• allergic reaction (may include shortness of breath, wheezing, swelling in the mouth or throat, hives, itching, flushing, or fever)*
• capillary leak syndrome*
• stroke

*See "Precautions" section for more detailed information