Because CUP represents a number of different cancers, there is no known way to prevent it. Still, certain lifestyle changes may reduce the risk of many types of cancer. This might in turn reduce a person's risk of CUP.

Smoking is one of the most significant risk factors that a person can control. About 1 out of 3 cancer deaths is thought to be the direct result of smoking. Quitting or never starting reduces the risk of cancers of many types, including those of unknown primary.

Factors linked with body weight, physical activity, and nutrition are also thought to cause about 1 out of 3 cancer deaths. Maintaining a healthy weight throughout life, being physically active, eating a healthy diet with an emphasis on plant-based foods, and limiting alcohol consumption can all help reduce your risk of cancer.

Because the exact type and the origin of a CUP are unknown, it is not possible to say how any particular case might have been prevented. It is important to realize that many people with cancer have no apparent risk factors, and there is nothing they could have done to avoid the disease.

Last Medical Review: 10/15/2009
Last Revised: 10/15/2009