Molecular pathology of uterine sarcoma

Recent research has improved our understanding of how changes in certain molecules can cause normal cells to become cancerous. For several years we have known that mutations (damage or defects) to DNA can alter important genes that regulate cell growth. If these genes are damaged, excess growth may result in cancer formation. Analysis of DNA from uterine sarcomas has revealed several changes in the genes that control cell growth. Scientists expect that these discoveries will eventually lead to new strategies for detection, prevention, and treatment.

Clinical trials

New drugs, as well as new ways to give standard drugs are being tested. One drug under study, trabectedin (Yondelis) has had some promising results in early trials of patients with sarcoma. Another drug, temozolomide, which is approved to treat brain tumors, also seems to help patients with sarcoma. Adjuvant radiation and chemotherapy continue to be evaluated for treatment of uterine sarcomas. New compounds are also being evaluated in soft-tissue sarcomas. Some of these compounds act differently from traditional chemotherapy drugs and are called targeted therapies.

Last Medical Review: 10/15/2008
Last Revised: 10/15/2008