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Nausea and Vomiting

What is nausea and vomiting?

Nausea and vomiting often happen at the same time, but can be 2 different problems.

Nausea is an unpleasant feeling in the back of your throat and stomach that may lead to vomiting. Some other ways people describe nausea are "sick to my stomach," "queasy," or "upset stomach." Other symptoms that may happen along with nausea are increased saliva (spit), dizziness, light-headedness, trouble swallowing, skin temperature changes, and a fast heart rate.

People often refer to vomiting as "throwing up." When you vomit, your stomach muscles contract (squeeze) and push the contents of your stomach out through your mouth. You may or may not feel nauseated.

Sometimes people retch. This is when you try to vomit without bringing anything up from your stomach. Other words used to describe retching are "gagging" or "dry heaves."

How common is nausea and vomiting in people with cancer?

About 7 or 8 out of every 10 people treated for cancer have bouts of nausea and vomiting. But there are many medicines that work well to control nausea and vomiting, and you should not suffer.

Drugs used to control these side effects are called as anti-nausea/vomiting drugs. You may also hear them called anti-emetics. Every person with cancer who is getting treatments that cause nausea or vomiting can, and should, get medicines to prevent them.

What problems can nausea and vomiting cause?

Nausea and vomiting are 2 of the most dreaded, unpleasant side effects of cancer treatment, but they are seldom life-threatening. Repeated vomiting can lead to dehydration, which is a lack of fluid and minerals your body needs. This can become a serious problem very quickly. Be sure to let your cancer team know right away if you can't keep fluids down, if you can't take the medicines you need, or if your vomiting lasts 24 hours or longer.

Vomiting can also cause tiredness (fatigue), trouble concentrating, slow wound healing, weight loss, and loss of appetite. It can interfere with your ability to take care of yourself and may lead to changes in your treatment plan. When nausea and vomiting are severe or long-lasting, and interfere with your normal daily activities, the outcomes are even worse.

What do I need to know about nausea and vomiting?

Ask your doctor or a member of your health care team these questions:

  • Is my cancer treatment likely to cause nausea and vomiting?
  • Are there effective treatments to prevent or control my nausea and vomiting?
  • How will you decide which anti-nausea/vomiting treatment I should use?
  • Are there side effects to the anti-nausea/vomiting treatments you want me to use?
  • When and how often shoud I take each medicine?
  • What else can be done if the treatment does not control my nausea and vomiting?

You will also want to know in what situations your doctor wants you to call. For example, some doctors want you to call them if you are vomiting or if you can't keep down fluids or medicines. And you'll want to know how to reach your cancer team on weekends or at night if these problems happen.

Causes of nausea and vomiting in people with cancer

Nausea and vomiting in the person with cancer can be caused by many different things:

  • chemotherapy, also called chemo
  • radiation therapy
  • the cancer itself
  • certain other medicines
  • bowel slow down (paresis) or blockage (obstruction)
  • inner ear problems
  • an imbalance of minerals and salts (electrolytes) in the blood
  • infections
  • axiety
  • the expectation of vomiting due to earlier experiences (anticipatory vomiting)
  • other diseases or illnesses

This information is about the nausea and vomiting caused by chemo or radiation therapy. Talk to your health care team about what treatments you can use to keep from having nausea and vomiting.

How do nausea and vomiting happen?

Doctors think that vomiting is most likely controlled by the part of the brain called the vomiting center. Less is known about how nausea occurs. When you are given chemo, 2 things happen:

  • a certain area of the brain is triggered
  • certain areas of the esophagus (the swallowing tube), stomach, small intestine, and large intestine are triggered

Chemo is thought to cause vomiting in both of these ways.

How likely are you to have nausea and vomiting with chemo?

How likely you are to have nausea and vomiting when you are getting chemo is affected by many different things, including:

  • the types of chemo drugs used
  • the dose of the drugs (high doses of chemo are more likely to cause nausea and vomiting)
  • when and how often the drug is given; for example, if doses of a chemo drug that causes nausea and vomiting are given close together, there is less time for the person to recover from the nausea and vomiting before the next treatment is given
  • how the drugs are given; for instrance, chemo given into a vein (intravenous, or by IV) may cause nausea and vomiting much faster than a drug  given by mouth, because the drug given by IV is absorbed faster
  • individual differences, since not every person has the same reaction to a dose or type of chemo
Some of the individual risk factors that may make you more likely to have nausea and vomiting include:
  • being female
  • being younger than 50
  • having had morning sickness during pregnancy
  • being very anxious
  • having ever had motion sickness
  • being prone to vomiting when you are sick
  • having been a light drinker (of alcohol)

Your doctor may consider all of these things when choosing the anti-nausea/vomiting medicines to use with your cancer treatment.

Types of nausea and vomiting

There are different types of nausea and vomiting. Chemo-related nausea and vomiting can be

  • acute
  • delayed
  • anticipatory
  • breakthrough
  • refractory

Acute nausea and vomiting usually happens a few minutes to hours after the chemo is given. It goes away within the first 24 hours. The worst vomiting most often happens 5 or 6 hours after chemo.

Delayed nausea and vomiting starts more than 24 hours after chemo is given. It is more likely with certain types of chemo, such as cisplatin, carboplatin, cyclophosphamide, and doxorubicin. For example, cisplatin-related vomiting is usually worst from 48 to 72 hours after chemo and can last 6 to 7 days.

Anticipatory nausea and vomiting is a learned response. It is usually the result of previous unpleasant experiences with chemo that led to nausea and vomiting. It starts as you are getting ready for the next treatment--before you even get the chemo. You anticipate or expect that nausea and vomiting will happen like it did before. Most people with this problem only feel nausea, but some vomit as well.

Breakthrough nausea and vomiting occurs even though treatment is given to prevent it. When this happens, you need more or different anti-nausea/vomiting medicines.  You will need to start taking these medicines regularly during your chemo treatment to prevent further nausea and vomiting.

Refractory vomiting may happen after one, a few, or even several chemo treatments. In this case, even though you are being treated to prevent or control nausea and vomiting, the anti-nausea and vomiting treatment is no longer working. Your nausea and vomiting have become refractory (no longer respond) to the medicines you are getting to prevent it. When this happens you will need more or different anti-nausea/vomiting medicines.

The risk of nausea and vomiting with chemo

Some chemo drugs are more likely to cause nausea and vomiting than others. Yo can describe the chance of chemo causing nausea and vomiting when effective anti-nausea/vomiting treatment is not given by using these 4 risk groups:

  • minimal vomiting risk: these chemo drugs cause vomiting in less than 10% of people who do not get effective anti-nausea and vomiting treatment
  • low vomiting risk: these chemo drugs cause vomiting in 10% to 30% of people who do not get effective anti-nausea and vomiting treatment
  • moderate vomiting risk: these chemo drugs cause vomiting in 30% to 90% of people who do not get effective anti-nausea and vomiting treatment. Most of thse drugs can cause nausea and vomiting for at least 4 days after the last dose.
  • high vomiting risk: these chemo drugs cause vomiting in more than 90% of people who do not get effective anti-nausea and vomiting treatment. Most of thse drugs can cause nausea and vomiting for at least 4 days after the last dose.

Please remember that these percentages apply if no effective nausea and vomiting treatment is given. Keep in mind that many of these drugs can cause more nausea than vomiting. For example, 40% of the people who take a drug may feel nausea, but only 20% vomit. So this drug would appear on the low risk of vomiting list, even though the risk of nausea is higher. Use these risk groups as a guide for discussions between you and your doctor and nurse.

Chemo drugs by name and their risk of nausea and vomiting

As noted before, chemo drugs are often grouped by how likely they are to cause vomiting when they are given alone, without anti-nausea/vomiting treatment:

Drugs with minimal risk (less than 10%) of vomiting

  • Alemtuzumab (Campath®)
  • Asparaginase (Elspar®)
  • Bevacizumab (Avastin®)
  • Bleomycin (Blenoxane®)
  • Busulfan (low-dose)
  • Chlorambucil (by mouth) (Leukeran®)
  • Cladribine (Leustatin®)
  • Cytarabine (very low-dose) (ara-c, Cytosar®)
  • Dasatinib (Sprycel®)
  • Decitabine (Dacogen®)
  • Denileukin diftitox (Ontak®)
  • Dexrazoxane (Zinecard®)
  • Erlotinib (Tarceva®)
  • Fludarabine (Fludara®)
  • Gefitinib (Iressa®)
  • Gemtuzumab (Mylotarg®)
  • Hydroxyurea (by mouth) (Hydrea®)
  • Lenalidomide (Revlimid®)
  • Melphalan (low-dose, by mouth) (Alkeran®)
  • Mercaptopurine (Purinethol®)
  • Methotrexate (low-dose)
  • Nelarabine (Arranon®)
  • Pegaspargase (Oncaspar®)
  • Pentostatin (Nipent®)
  • Rituximab (Rituxan®)
  • Sorafenib (Nexavar®)
  • Sunitinib (Sutent®)
  • Temsirolimus (Torisel®)
  • Thalidomide (Thalomid®)
  • Thioguanine (by mouth)
  • Valrubicin (Valstar®)
  • Vinblastine (Velban®)
  • Vincristine (Oncovin®)
  • Vinorelbine (Navelbine®)

Drugs with a low risk (10% to 30%) of vomiting

  • Aldesleukin (low-dose)
  • Amifostine (lower doses) (Ethyol®)
  • Bexarotene (Targretin®)
  • Bortezomib (Velcade®)
  • Capecitabine (Xeloda®)
  • Cetuximab (Erbitux®)
  • Cytarabine (low-dose) (Cytosar®, ara-c)
  • Docetaxel (Taxotere®)
  • Doxorubicin (liposomal) (Doxil®)
  • Etoposide (Vepesid®, VP-16®)
  • Everolimus (Afinitor®)
  • Fludarabine (by mouth) (Fludara®)
  • 5-Fluorouracil (5-FU®)
  • Gemcitabine (Gemzar®)
  • Imatinib (Gleevec®)
  • Interferon alfa (moderate-dose) (IntronA®, Roferon-A®)
  • Ixabepilone
  • Lapatinib (Tykerb®)
  • Methotrexate (moderate-dose)
  • Mitomycin (Mutamycin®)
  • Mitoxantrone (Novantrone®)
  • Nilotinib (Tasigna®)
  • Paclitaxel (Taxol®)
  • Paclitaxel-albumin (Abraxane®)
  • Pemetrexed (Alimta®)
  • Topotecan (Hycamtin®)
  • Trastuzumab (Herceptin®)
  • Vorinostat (Zolinza®)

Drugs with a moderate risk (30% to 90%) of vomiting

  • Aldesleukin (higher doses) (IL-2, Proleukin®)
  • Amifostine (higher doses) (Ethyol®)
  • Arsenic trioxide (Trisenox®)
  • Azacitidine (Vidaza®)
  • Bendamustine (Treanda®)
  • Busulfan (high-dose)
  • Carboplatin
  • Carmustine (lower doses) (BCNU®)
  • Cisplatin (lower doses)
  • Clofarabine (Clolar®)
  • Cyclophosphamide (lower doses) (Cytoxan®)
  • Cyclophosphamide by mouth (Cytoxan®)
  • Cytarabine (high-dose) (Cytosar®, ara-c)
  • Dactinomycin
  • Daunorubicin
  • Doxorubicin (Adriamycin®)
  • Epirubicin (Ellence®)
  • Etoposide by mouth (Vepesid®, VP-16®)
  • Idarubicin (Idamycin®)
  • Ifosfamide (Ifex®)
  • Irinotecan (Camptosar®)
  • Lomustine (CeeNU®)
  • Melphalan (higher doses) (Alkeran®)
  • Methotrexate (high-dose)
  • Oxaliplatin (Eloxatin®)
  • Temozolomide (Temodar®)

Drugs with a high risk (greater than 90%) of vomiting

  • Altretamine (Hexalen®)
  • Carmustine (high-dose) (BCNU®)
  • Cisplatin (moderate- to high-dose)
  • Cyclophosphamide (high-dose) (Cytoxan®)
  • Dacarbazine (DTIC®)
  • Doxorubicin (Adriamycin®) or epirubicin (Ellence®) given with cyclophosphamide (Cytoxan®)
  • Mechlorethamine (Mustine®, nitrogen mustard, Mustargen®)
  • Procarbazine
  • Streptozocin (Zanosar®)

So, for example, you can see that high doses of cisplatin and cyclophosphamide cause nausea and vomiting in more than 90% of people getting these drugs when no anti-nausea/vomiting treatment is given. On the other hand, bleomycin or vincristine cause nausea and vomiting in less than 10% of people who get these drugs and do not use anti-nausea/vomiting medicines.

This grouping system is meant to help you when you are talking to your doctor and nurse about your treatment plan. Use this list for information on the chemo drugs you will be getting. In general, your doctor should offer anti-nausea/vomiting treatment based on the drug that is most likely to cause nausea and vomiting. This means that if at least one drug on your chemo list is in the "high risk" group, you should expect to get at least 2 or 3 different drugs to prevent nausea and vomiting.

Radiation therapy and nausea and vomiting

Whether radiation therapy causes nausea and vomiting depends on the part of the body being treated, the dose of radiation given, and how often the treatment is given. When the area of the body being treated includes a large part of the abdomen (belly) -- mainly the small intestine (or small bowel) -- there is a greater chance of nausea and vomiting.

About half of people with cancer who get standard doses (180 to 200 centiGray) of radiation to the abdomen have nausea and vomiting. These problems can start 1 to 2 hours after treatment and can last for hours. Of those being treated with total body radiation therapy (which is used in bone marrow transplants), up to 9 of every 10 people have nausea and vomiting if not given treatment to prevent it. These people may also get high doses of chemo to prepare for the transplant. And the combination of radiation therapy and chemo further raises the chance of nausea and vomiting. People who get one large dose of radiation have a greater chance of nausea and vomiting than those who get their radiation treatment in smaller doses.

How are nausea and vomiting prevented and treated?

Today, many medicines can be used to prevent or control nausea and vomiting and so there are many treatment options.

Radiation therapy and anti-nausea/vomiting medicines

When radiation treatment is likely to cause nausea and vomiting, your doctor will probably give you medicines to help prevent it each day before you get your radiation treatment. The anti-nausea/vomiting medicines may be given by mouth or into the vein, or both. If you have nausea or vomiting, be sure to tell your doctor so that it can be treated effectively.

Chemotherapy and anti-nausea/vomiting medicines

No one drug can prevent or control nausea and vomiting 100% of the time. This is because chemo drugs act on the body in different ways and because each person responds to chemo differently. To choose the best treatment plan, the doctor:

  • considers how likely the chemo is to cause nausea and vomiting if no anti-nausea/vomiting treatment is given
  • selects anti-nausea/vomiting medicines based on how much the chemo drugs are known to affect the vomiting center in the brain
  • looks at your history of nausea and vomiting
  • reviews how well any anti-nausea/vomiting medicines have worked for you before
  • looks at the side effects of the anti-nausea/vomiting medicines
  • uses the lowest effective dose of the anti-nausea/vomiting medicine before chemo or radiation therapy is given
  • uses medicines to try to prevent (not just control) the nausea and vomiting
  • carefully watches how you respond to the anti-nausea/vomiting treatment

The goal is to prevent nausea and vomiting, because it's easier to prevent it than it is to stop it once it starts. To help the drugs work best against chemo-related nausea and vomiting:

  • preventive treatment should start before the chemo is given
  • it should continue for as long as the chemo is likely to cause vomiting, which can be up to a week or even 10 days after the last dose

Anti-nausea/vomiting medicines are usually given on a regular schedule around the clock. Sometimes you may be asked to take a medicine on an "as needed" schedule -- you take the medicine at the first sign of nausea to keep it from getting worse. Because nausea and vomiting can happen for different reasons, different anti-nausea/vomiting medicines may be used together. Two or more medicines are often used. Be sure you know how to take each drug. And, ask your doctor or nurse how long after the last dose of chemo you should keep taking your medicine to prevent nausea and vomiting, so that you don't stop taking it too soon.

Each time you start a new cycle of chemo, be sure to tell your cancer team what did and didn't work the last time. This is a time to get better control of your nausea and vomiting so that it isn't a problem for the next round, and it is a chance for the doctor to be sure that there aren't other factors besides the chemo adding to your nausea and vomiting

Anti-nausea/vomiting medicines

There are many different anti-nausea/vomiting medicines. These drugs work better in some people than in others.

You will get anti-nausea/vomiting medicines based on which chemo drugs you are getting. For example, if you are getting a chemo drug that is likely to cause nausea and vomiting, you should get the anti-nausea/vomiting medicine that has proven to work best in other people who got that same drug. If these medicines do not prevent your nausea and vomiting, it is important to tell your doctor so you can get different medicines. You might have to try a few different medicines to find the ones that work best for you. Some of the most common anti-nausea/vomiting medicines are listed below.

Commonly used anti-nausea/vomiting medicines by generic and brand name:


Generic name Brand name
Alprazolam Xanax®
Aprepitant Emend®
Dexamethasone Decadron®
Diphenhydramine Benadryl®
Dolasetron Anzemet®
Dronabinol Marinol®
Granisetron Kytril®
Haloperidol Haldol®
Lorazepam Ativan®
Metoclopramide Reglan®
Nabilone Cesamet®
Ondansetron Zofran®
Olanzapine Zyprexa®
Palonosetron Aloxi®
Prochlorperazine Compazine®
Promethazine Phenergan®

Common anti-nausea/vomiting medicines and how they are used:

Aprepitant: Anti-nausea/vomiting medicine; works differently from all others; used for acute and delayed nausea and vomiting

Dexamethasone: A steroid used alone and with other anti-nausea medicines; given by mouth or in the vein

Diphenhydramine: An antihistamine that helps decrease side effects from other anti-nausea medicines; used for low-risk chemo or when other medicines do not work; given along with other medicines; does not work well as an anti-nausea medicine when used alone

Dolasetron, granisetron, ondansetron: Anti-nausea/vomiting medicines; can be given by mouth or IV (into a vein), granisetron is also available as a patch; each works equally well

Dronabinol, nabilone: Used when other anti-nausea medicines do not work; tetrahydrocannabinol (THC) is the active ingredient; younger adults have fewer side effects

Haloperidol: Also used as a tranquilizer, works as anti-nausea medicine when used along with other medicines; used when other anti-nausea medicines don't work

Lorazepam, alprazolam: Used to reduce anxiety; often used with other anti-nausea medicines; both have calming (tranquilizing) and anti-nausea effects; can be used for anticipatory nausea and vomiting

Metoclopramide: Used for low-risk chemo or when other agents do not work; may be used alone or along with other medicines

Olanzapine: Sometimes used when other medicines do not work; affects a number of message carriers in the brain

Palonosetron: Anti-nausea/vomiting medicine much like dolasetron, granisetron, ondansetron, but it is only given by IV; works for both acute and delayed nausea and vomiting

Prochlorperazine: Used for low-risk chemo or when other agents do not work; may be used alone or along with other medicines

Promethazine: Used when other medicines do not work

How are the anti-nausea/vomiting medicines given?

Anti-nausea/vomiting medicines are given in different ways based on

  • how bad your nausea and vomiting is,
  • the easiest way for you to take the medicine, and
  • what you prefer

Taking pills by mouth is often the best and easiest way to prevent nausea and vomiting. But if you are already vomiting, or you can't swallow and keep things down, many of these medicines can be given in other ways. Not all anti-nausea/vomiting drugs can be given in all these ways, but talk with your doctor about other ways you can get the medicine you need if you can't take it as a pill:

  • Some can be given IV or intravenously (into a vein)
  • Others come as suppositories that are put in the rectum
  • Some are made into tablets that are put under the tongue (sublingual)
  • A few of these medicines come as patches that stick on the skin (transdermal)

How a medicine is given does not change how well it works to prevent or control nausea and vomiting. But it often affects how quickly it starts working. Drugs that are given into the vein or under the tongue usually start working faster.

Other treatments for nausea and vomiting

Although anti-nausea/vomiting medicines are the main treatment for nausea and vomiting, there are some non-drug treatments that can be used. These non-drug treatments involve using your mind and body with the help of a qualified therapist. If you would like to try one of these methods, ask a member of your health care team to refer you to a therapist trained in these techniques. Non-drug treatments may be used alone for mild nausea or for anticipatory nausea and vomiting. When taking chemo drugs that are likely to cause nausea and vomiting, they may be used along with anti-nausea/vomiting medicines. All of these methods try to decrease nausea and vomiting by helping to:

  • relax you
  • distract you from what's going on
  • help you feel in control
  • make you feel less helpless

Here are some non-drug treatments that have helped some people. Most of these treatments have few or no side effects. And with the proper training, nearly anyone can use most of these.

Self-hypnosis

Self hypnosis was the first technique used to make behavior changes to control nausea and vomiting. It involves creating a state of intense attention, willingness, and readiness to accept an idea. It has been shown to work very well with children and teens.

Progressive muscle relaxation

Progressive muscle relaxation (PMR) teaches a person to relax by progressively tensing and releasing different muscle groups. It has been used to decrease the nausea and vomiting caused by chemo. Patients who learn PMR often go on to use this method as a way to cope with other stresses too. It is also used to help with nervousness, pain, anger, headaches, and depression.

Biofeedback

This is a technique that helps people reach a state of relaxation. Using biofeedback, a person learns to control a certain physical response of the body, such as nausea and vomiting. This is done by tuning in to the moment-to-moment body changes that are linked to the physical response. For example, biofeedback can be used to prevent skin temperature changes, such as those that often happen before nausea and vomiting starts. The use of biofeedback alone for nausea and vomiting has not been found to work as well as the combination of biofeedback and PMR.

Guided imagery

Guided imagery allows people to remove themselves mentally from the treatment center and imagine that they are in a place that is relaxing for them. The place can be a vacation spot, a room at home, or some other safe or pleasant place. While trying to imagine what they usually feel, hear, see, and taste in the pleasant place, some people can mentally block the nausea and vomiting.

Systematic desensitization

Systematic desensitization helps people learn how to imagine an anxiety-producing situation (such as nausea and vomiting) and reduce the anxiety related to the situation. In most cases, what a person can imagine without anxiety, he or she can then experience in the real world without anxiety.

Music therapy

Specially trained health professionals use music to help relieve symptoms. Music therapists may use different methods with each person, depending on that person's needs and abilities. There is some evidence that, when used with standard treatment, music therapy can help to relieve nausea and vomiting due to chemo. It can lower heart rate and blood pressure, relieve stress, and give a sense of well-being.

Acupuncture or acupressure

Acupuncture is a traditional Chinese technique in which very thin needles are put into the skin. There are a number of different acupuncture techniques, including some that use pressure rather than needles. Some clinical studies have found it may help treat nausea caused by chemo.

Eating right can help you get through cancer treatment

Nausea and vomiting can affect how much you eat and what you eat. And good nutrition is key for people being treated for cancer. Many factors related to the illness itself, as well as cancer treatments, may affect appetite and the body's ability to take in food and use nutrients. Your nutritional needs will vary during cancer treatment. Your health care team can help you come up with nutrition goals and find an approach to eating that meets your needs. Eating healthy foods while going through cancer treatment can help you:

  • feel better
  • keep up your strength and energy level
  • stay at a healthy weight
  • keep up your body's store of nutrients
  • better handle treatment-related side effects
  • lower your risk of infection
  • recover and heal as quickly as possible

Eating well means eating many different kinds of foods that will give you the nutrients you need for healing.

Nutrition suggestions for people getting chemo

Here are some suggestions that may help reduce nausea and vomiting if you are getting chemo.

  • On the days you get chemo, make sure you have had something to eat. Most people find that a light meal or snack before chemo is best.
  • In most cases, chemo is given on an outpatient basis, such as in an infusion center or a doctor’s office. Getting chemo can take a few minutes or many hours. Plan ahead and bring a light meal or snacks with you. Many treatment centers have refrigerators and microwaves you can use.
  • Fatigue (being tired or lacking energy) is very common when getting chemo. Here are some things you can do to deal with fatigue: save your energy, set priorities, pace yourself, ask others to do chores, plan activities when you have the most energy, know your limits, and eat balanced meals.
  • Don't be too hard on yourself if side effects make it hard to eat. Try eating small, frequent meals or snacks. Choose the foods that appeal to you the most. Your taste can change on an almost day-to-day basis when you are getting cancer treatment.
  • Make the most of days when you feel well and your appetite is good. Always try to eat regular meals and snacks but listen to your body. Never force yourself to eat something that you don't want, or if you feel full.
  • Ask family and friends for help with shopping and cooking. If you don't have help, think about having meals delivered to your home or maybe having lunch at a local community or senior center. Contact community assistance organizations, area churches, or your local American Cancer Society office for more ideas.
  • Most side effects are short-term and go away when treatment is over. If symptoms last, you should tell your health care team. Nutrition-related side effects should be dealt with right away to help you keep up your weight and energy.

Nutrition suggestions for people getting radiation therapy

The types of side effects you have during radiation therapy depend on the part of your body getting radiation, the size of the area being treated, the total dose of radiation, and the number of treatments. The list below shows different parts of the body that may be treated and the possible side effects that may make it hard to eat.

  • Brain, spinal cord: nausea, vomiting
  • Tongue, voice box, tonsils, salivary gland, nose, throat (pharynx): sore mouth, trouble swallowing or pain with swallowing, change in or loss of taste, sore throat, dry mouth, thick saliva
  • Lung, esophagus, breast: trouble swallowing, heartburn
  • Large or small intestine, prostate, uterus, cervix, rectum, pancreas: loss of appetite, nausea, vomiting, diarrhea, gas, bloating

Eating well is important both during and after treatment. If side effects develop or if the anti-nausea/vomiting medicines are not working, talk to your health care team.

Some patients need to be treated at a center far from their home, which may make it hard for them to eat well. Most treatment centers have some type of kitchen space. Patients can use this area to store and prepare frozen foods, soups, single servings of fruits, puddings, gelatin, ice cream, or cereals. If there is no kitchen, bring food items that do not need refrigeration, such as single serving packs of canned fruit, gelatin, puddings, cheese or peanut butter crackers, granola bars, or cereal. A nurse or social worker might be able to give you ideas about places to stay and eat while you are getting treatment.

Here are some eating tips you can try if you are getting radiation therapy:

  • Try to eat something at least an hour before treatment rather than going to treatment with an empty stomach.
  • Bring foods or nutrition supplements to eat or drink on the ride to and from treatment if you must travel a long distance for treatment each day,
  • Eat small, frequent meals. Ask friends and family members to help prepare meals, do the shopping, and choose the foods and drinks you enjoy the most.
  • Do not expect to have the same side effects as someone else being treated for cancer in another part of the body. Even people with the exact same treatments have different degrees of side effects.
  • Get to know other cancer patients and talk with them about their experiences, or join a support group. Other patients can be a great source of information and support.

Managing the side effects that make it hard for you to eat right

If you are having trouble eating and/or you are on a special diet (such as for diabetes or heart disease), your food restrictions might be relaxed during cancer treatment. But you should speak with your health care team before making any changes. Here are some things you can do to try to eat as well as possible during treatment:

  • Try to eat small frequent meals rather than 3 large meals.
  • Add extra calories and protein to foods. Liquid or powdered nutrition supplements are handy and can be helpful during this time. Try different brands and flavors to find out which ones taste best and work best for you. Your doctor, nurse, or a dietitian may be able to tell you more about types of products available and may have samples you can try.
  • Try eating most foods during the time of day when you are best able to eat. Many people find that breakfast time is best.
  • Let your health care team know if eating is a problem. A dietitian can be consulted to give you more tips to help with eating.
  • Let your health care team know when anti-nausea/vomiting medicines don't work.

There are also things you can do to help manage or reduce your nausea and vomiting. Here are a few suggestions:

  • Eat foods and drink beverages that are "easy on the stomach" or made you feel better when you had the flu or morning sickness. These are often things like ginger ale, bland foods, sour candy, and dry crackers or toast.
  • Do NOT force yourself to eat when you feel nauseated.
  • Limit your fluids while eating.
  • Eat food cold or at room temperature.
  • Have someone else make the meals if you have nausea.
  • Keep your mouth clean; clean your mouth each time after vomiting.
  • Wear loose fitting clothes.
  • Get fresh air with a fan or open window.
  • Limit sounds, sights, and smells that cause nausea and vomiting.
  • Call your doctor or nurse if your nausea or vomiting is not prevented or controlled with the medicines you have.

You can get more information on eating during cancer treatment in our booklet, Nutrition for the Person with Cancer During Treatment: A Guide for Patients and Families.

Nausea and vomiting can be an unpleasant side effect of cancer treatment. But they should not be accepted as a part of cancer treatment that can't be changed. Talk to your health care team if you are having nausea and vomiting. Be willing to work with them to find the right anti-nausea/vomiting medicines for you.

Additional resources

More information from your American Cancer Society

We have selected some related information that may also be helpful to you. These materials may be viewed on our Web site or ordered from our toll-free number, 1-800-ACS-2345 (1-800-227-2345).

You can also get more information on each drug used to treat cancer, as well as drugs used to treat nausea and vomiting, by calling us or visiting our Web site.

The following books are available from the American Cancer Society. Please call us to ask about costs or place your order:

National organizations and Web sites*

In addition to the American Cancer Society, other sources of patient information and support include:

CancerCare
Toll-free number: 1-800-813-4673 (1-800-813-HOPE)
Web site: www.cancercare.org
Provides information and free professional support by phone and online to people with cancer, their loved ones, and caregivers.

Meals on Wheels Association of America (MOWAA)
Telephone number: 703-548-5558
Web site: www.mowaa.org
A group of programs that provide home-delivered meals. Some programs may provide other services such as transportation, education, information, and case management.

National Cancer Institute
Toll-free number: 1-800-422-6237 (1-800-4-CANCER)
TTY: 1-800-332-8615
Web site: www.cancer.gov
Offers information on cancer treatments, symptoms, and coping. More on nausea and vomiting can be found at: www.cancer.gov/cancertopics/pdq/supportivecare/nausea/Patient

*Inclusion on this list does not imply endorsement by the American Cancer Society.

No matter who you are, we can help. Contact us anytime, day or night, for cancer-related information and support. Call us at 1-800-227-2345 or visit www.cancer.org.

References

Manufacturers' Product Information. Accessed directly from companies and also online at: www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm on September 10, 2009.

National Cancer Institute. Nausea and Vomiting PDQ®. Accessed at: www.cancer.gov/cancertopics/pdq/supportivecare/nausea/HealthProfessional/page1 on September 10, 2009.

National Comprehensive Cancer Network. Antiemesis. NCCN Clinical Practice Guidelines in Oncology – v.4.2009. Accessed at: www.nccn.org/professionals/physician_gls/PDF/antiemesis.pdf on September 9, 2009.

Schwartzberg LS. Chemotherapy-induced nausea and vomiting: clinician and patient perspectives. J Support Oncol. 2007;5(2 Suppl 1):5-12.

Last Medical Review: 09/29/2009
Last Revised: 09/29/2009

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