• work with your doctors, nurses, and pharmacists to find the best ways to control your pain 
• know about different types of pain and how each type is treated 
• know about different types of available pain medicines 
• know about ways to control pain without drugs 
• take your medicines safely 
• talk with your doctors and nurses about your pain and how well your treatment is working for you

Having cancer does not always mean having pain. But for people who do have pain, there are many different kinds of medicines, different ways to take the medicines, and non-medicine methods that can help relieve pain.

You should never accept pain as a normal part of having cancer. All pain can be treated, and most pain can be controlled or relieved. When your pain is controlled, you can sleep and eat better, enjoy being with family and friends, and continue with your work and hobbies.

Only you know how much pain you are in. Telling your doctor and nurse when you are in pain is very important because pain easier to treat when it first starts. It can also be an early warning sign of the side effects of your cancer or your cancer treatment. Together -- you, your nurse, and your doctor -- can talk about how to treat your pain. You have a right to pain relief, and you should insist on it.

Facts About Cancer Pain Treatment

Cancer pain can almost always be relieved or lessened.

There are many different medicines and methods that can be used to control cancer pain. You should expect your health care team to work with you to keep you as comfortable as possible. But no one doctor can know everything about all medical problems. If you are in pain and your doctor has nothing more to offer, ask to see a pain specialist or have your doctor consult with a pain specialist. Pain specialists may be oncologists, anesthesiologists, neurologists, neurosurgeons, other doctors, nurses, or pharmacists. A pain control team may also include psychologists and social workers.

If you have trouble finding a pain program or specialist, contact a cancer center, a hospice, or the oncology department of your local hospital or medical center. They should be able to recommend someone to you.

Controlling your cancer pain is part of your cancer treatment.

Your doctor wants and needs to hear about what works and what does not work for your pain. Knowing about the pain will help your doctor better understand how the cancer and the treatment are affecting your body. Talking about pain will not distract your doctor from treating the cancer.

Keeping pain from starting or getting worse is the best way to control it.

Pain is best relieved when treated early. You may hear some people refer to this as "staying on top" of the pain. Do not try to hold off as long as possible between doses. Pain may get worse if you wait, and it may take longer, or you may need larger doses, for your medicine to give you relief.

You have a right to ask for pain relief.

Talking about your pain is not a sign of weakness. Not everyone feels pain in the same way. There is no need to be stoic or brave if you seem to have more pain than other people with the same kind of cancer. In fact, as soon as you have any pain you should speak up. Remember, it is easier to control pain right when it starts rather than waiting until after it becomes severe.

People who take cancer pain medicines the way the doctor or nurse tells them to rarely become addicted to them.

Addiction is a common fear of people taking pain medicine. Such fear may even keep people from taking the medicine. Or it may cause family members to encourage you to hold off as long as possible between doses. Addiction is defined as uncontrollable drug craving, seeking, and use. When opioids (also known as narcotics) -- the strongest pain relievers available -- are taken for pain, they rarely cause addiction as defined here. When you are ready to stop taking opioids, the doctor will lower the amount of medicine you are taking over a few days or weeks. By the time you stop using it completely, your body has had time to adjust. Talk to your doctor, nurse, or pharmacist about how to use pain medicines safely and about any concerns you have about addiction.

Most people do not get "high" or lose control when they take cancer pain medicines the way they are told to.

Some pain medicines can cause you to feel sleepy when you first start taking them. This feeling usually goes away within a few days. Sometimes you become drowsy because now that the pain is under control you are able to catch up on the much needed sleep you missed when you were in pain. Sometimes, people get dizzy or feel confused when they take pain medicines. Tell your doctor or nurse if this happens to you. Changing your dose or type of medicine can usually solve these problems.

Side effects from pain medicines can be managed and often even prevented.

Some medicines can cause constipation, nausea and vomiting, or drowsiness--these are discussed in more detail later. Your doctor or nurse can help you manage these side effects. But many of these problems go away after a few days of taking the medicine. Many side effects can be managed by changing the medicine, the dose, or the times when the medicine is taken.

Your body does not become immune to pain medicine.

Pain should be treated early, and stronger medicines should not be saved for later. It is important to take whatever medicine is needed when it is needed. Your body may get used to the medicine you are taking, then the medicine may not relieve the pain as well as it once did. This is called tolerance. Tolerance is not usually a problem with cancer pain treatment because yor doctor can change the amount of medicine you are taking or add other medicines.

When pain is not relieved, you may feel:

• Tired 
• Depressed 
• Angry 
• Worried 
• Lonely 
• Stressed

When cancer pain is relieved, you can:

• Enjoy being active 
• Sleep better 
• Enjoy family and friends 
• Eat better 
• Enjoy sexual intimacy 
• Prevent depression

About Cancer Pain

What Are the Different Types of Pain?

Acute or Chronic Pain

Pain may be acute or chronic. Acute pain is severe and lasts a relatively short time. It is usually a sign that the body is being injured in some way, and the pain generally goes away when the injury heals. Chronic or persistent pain may range from mild to severe, and it is present for long periods of time.

Breakthrough Pain

Some people with chronic pain that is controlled by medicine can have breakthrough pain. This is when moderate to severe pain "breaks through" or is felt for a short time. It may happen many times a day, even when the proper dose of medicine is given for the chronic pain. Breakthrough pain is discussed in more detail in the next section.

What Causes Pain in People with Cancer?

The pain you feel may be from the cancer itself. Whether you have pain and the amount of pain you have depends on the type of cancer, the stage (extent) of the disease, and your pain threshold (tolerance for pain). Most of the pain comes when a tumor presses on bones, nerves, or body organs. But it can also be caused by the treatment or the tests done to diagnose cancer. You may also have pain that has nothing to do with your illness or treatment. Like anyone, you can get headaches, muscle strains, and other aches and pains.

Pain From Procedures

Some tests used to diagnose cancer and to see how well the treatment is working are painful. If you and your doctors agree that a diagnostic procedure is needed, concern about pain should not keep you from having the procedure. Usually any pain you have during and after the procedure can be relieved. Your needs and the type of procedure to be done should determine the kinds of medicine that can be given for the pain. You may be told that the pain from the procedure can't be avoided or that it won't last long. Even so, you should ask for pain medicine if you need it.

Phantom Pain

If you have had an arm or leg removed by surgery, you may still feel pain or other unusual or unpleasant feelings that seem to be coming from the absent (phantom) limb. Doctors are not sure why this happens, but phantom limb pain is real; it is not in your mind. This pain can also happen if you have had a breast removed -- you may have a sensation of pain in the area of the missing breast.

No single pain relief method controls phantom pain in all patients all the time. Many methods have been used to treat this type of pain, including pain medicine, physical therapy, antidepressant medicines, and transcutaneous electric nerve stimulation (TENS). If you are having phantom pain, ask your doctor, nurse, or pharmacist what can be done.

Spinal Cord Compression

When a tumor spreads to the spine, it can press on the spinal cord and cause spinal cord compression. The first sign of the compression is usually back and/or neck pain. Coughing, sneezing, or other movements often make it worse. If you have this pain, it is important to tell your doctor right away. Your doctor can treat the cause of the pain and also give you medicine to relieve the pain. If you get treatments for the compression soon after the pain begins, complications such as bladder or bowel problems can usually be avoided. Treatments usually involve radiation therapy to shrink the tumor, or surgery to remove the tumor followed by radiation.

Breakthrough Pain

People with cancer pain often notice that their pain changes throughout the day. Many people with chronic cancer pain (pain that lasts longer than 3 months) have two types of pain -- persistent pain and breakthrough pain. Persistent (continuous) pain is usually controlled by pain medicines taken around the clock (on a regular schedule). Breakthrough pain is pain that is not controlled by the regular doses of pain medicines.

Breakthrough pain is often a severe flare of pain that occurs even though a person may be taking pain medicine regularly for their persistent pain. It's called breakthrough pain because it is pain that "breaks through" a regular pain medicine schedule. It is common for people with persistent pain to experience episodes of breakthrough pain. Breakthrough pain may be different for each person and the person usually cannot predict when it will happen. As a rule, it comes on quickly, lasts as long as an hour, and feels much like persistent pain except that it is more severe or intense.

Breakthrough pain is shown above as spikes through the relief provided by the around-the-clock analgesic (pain medicine to treat persistent pain). Breakthrough pain varies in intensity and usually cannot be predicted.

What Causes Breakthrough Pain?

Breakthrough pain usually has the same cause as persistent pain. It may be the cancer itself or it may be related to cancer treatment. Some people have breakthrough pain during a certain activity, like walking or dressing. For others, it happens unexpectedly without any clear cause.

How Is Cancer Pain Treated?

Cancer pain is usually treated with drugs that are called analgesics, and with non-drug treatments such as relaxation techniques, biofeedback, guided imagery, and others. Ask your doctor, nurse, or pharmacist for advice before you take any medicine for pain. Medicines are safe when they are used properly. You can buy some very good pain relievers without a prescription or doctor's order (for example aspirin or ibuprofen). These medicines are also called non-prescription or over-the-counter (OTC) pain relievers. For other medicines, you will need a prescription from your doctor.

For a small number of people, medicines and non-drug treatments may not work but other treatments are available, including radiation therapy to shrink the tumor; surgery to remove part or all of the tumor; nerve blocks whereby pain medicine is injected into or around a nerve or into the spine to block the pain; and neurosurgery, where pain nerves are cut to relieve the pain.

Developing a Plan for Pain Control

The first step in developing a plan is talking with your doctor, nurse, and pharmacist about your pain. You need to be able to describe your pain to your health care team and also to your family or friends. You may want to have your family or friends help you talk to your health care team about your pain, especially if you are too tired or in too much pain to talk to them yourself.

Using a pain scale is helpful in describing how much pain you are feeling. To use the Pain Intensity Scale below, try to assign a number from 0 to 10 to your pain level. If you have no pain, use a 0. As the numbers get higher, they stand for pain that is getting worse. A 10 means it is the worst pain you have ever had.

0

1

2

3

4

5

6

7

8

9

10

For example, "My pain is a 7 on a scale of 0 to 10."

You can use the rating scale to describe:

• How bad your pain is at its worst 
• How bad your pain is most of the time 
• How bad your pain is at its least 
• How your pain changes with treatment

Tell your doctor, nurse, pharmacist, and family or friends:

• Where you feel pain 
• What it feels like -- sharp, dull, throbbing, steady 
• How strong the pain is (using the 0 to10 scale) 
• How long it lasts 
• What eases the pain 
• What makes the pain worse 
• What medicines you are taking for the pain and how much relief you get from them

Your doctor, nurse, and pharmacist may also need to know:

• What medicines you are taking now and what pain medicines you have taken in the past, including what has worked and not worked for you. You may want to keep records of this information. 
• Any known allergies to medicines

Questions you may want to ask your doctor or nurse about pain medicine:

• How much medicine should I take? How often can I take it? 
• If my pain is not relieved, can I take more? 
• If the dose should be increased, by how much? 
• Should I call you before increasing the dose? 
• What if I forget to take it or take it too late? 
• Should I take my medicine with food? 
• How much liquid should I drink with the medicine? 
• How long does it take the medicine to start working? 
• Is it safe to drink alcoholic beverages, drive, or operate machinery after I have taken pain medicine? 
• What other medicines can I take with the pain medicine? 
• What side effects from the medicine are possible, how can I prevent them, and what should I do if I have them?

Keeping a Record of the Pain

You may find it helpful to keep a record or a diary to track details about your pain and what works best to ease it. You can share this record with those caring for you. This will help them figure out what method of pain control works best for you. Your records can include:

• Words to describe the pain. 
• Any activity that seems to increase or decrease the pain. 
• Any activity that you cannot do because of the pain. 
• The name, dose, and time you take your pain medicines. 
• The times you use other pain-relief methods (such as rest, relaxation techniques, distraction, skin stimulation, or imagery). 
• The number you rate your pain at the time you use a pain-relief measure. 
• Pain rating 1 to 2 hours after using the pain-relief measure. 
• How long the pain medicine works. 
• Pain rating throughout the day (to get an idea of your general comfort). 
• How pain interferes with your normal activities, such as sleeping, eating, sexual activity, or working. 
• Any side effects you have.

Treating Chronic and Breakthrough Pain

Treating Chronic Pain

Drugs used to treat chronic or persistent pain have to work for long periods of time. They are called long-acting or sustained-release drugs and are taken at regular times or around the clock. You take these pain medicines on a schedule--even if you are not having pain at the time the medicine is due. By taking these drugs regularly, you can maintain a fairly constant level of pain relief through the day and night. These drugs may be given in the form of tablets or capsules taken every 8 to 12 hours or through a skin patch that is worn continually for several days. Again, these drugs are taken on a schedule and not just when you are in pain. Although the actions of the medicines used to treat breakthrough pain are short lived, long-acting drugs are slowly released into the body and provide pain control over a long period of time.

Treating Breakthrough Pain

Breakthrough pain is best treated with pain medicines that work quickly and for a short period of time. They are usually taken as needed, which means that they should be used as soon as breakthrough pain begins. These short-acting drugs (sometimes called rescue medicines) work faster than those used to manage persistent pain. They also stay in your body for a shorter time and cause fewer side effects.

You should take your short-acting medicine when you first begin to feel pain so that it can start to work on relieving your pain. Do not let the pain build up and become too severe because it will be much harder to get under control. Follow the directions given to you. If you notice that the usual dose does not relieve your breakthrough pain, or if you think you are having too many episodes of breakthrough pain, tell your doctor or nurse. They may need to adjust the dose or frequency of your pain medicine. You may also want to take a dose of your breakthrough medicine to prevent pain if you know that you are likely to have breakthrough pain during or after a particular activity.

So, that’s why I have been prescribed two different opioid pain medicines?

Yes. Since chronic pain and breakthrough pain are different types of pain, they are treated with pain medicines that work in different ways. Chronic pain is usually treated with long-acting drugs that are taken regularly to prevent as much pain as possible. Breakthrough pain is relieved with short-acting drugs that are taken only when you have episodes of breakthrough pain. The pain medicines that you have been prescribed work together to treat both your persistent pain and your breakthrough pain. Medicines for persistent pain take longer to work, but help to control your pain for hours or even days. Drugs used to treat breakthrough pain work faster, but for shorter time periods to directly control severe flare-ups of breakthrough pain.

If I have breakthrough pain, does it mean that the pain medicine I am using regularly for my chronic pain is not working well?

No. Breakthrough pain is an intense flare up of pain that is usually more severe than chronic pain. Remember, breakthrough pain is common in people with cancer pain. It can happen even when a person is taking the correct dose of pain medicine on a regular schedule for their chronic pain.

Still, let your doctor or nurse know if you are having more breakthrough flares and just how often you need your breakthrough medicine. Sometimes a dose increase in your chronic pain medicines may be needed.

How can I be sure that I’m getting the right dose of breakthrough pain medicine?

Your breakthrough pain medicine should relieve most of your breakthrough pain without causing unacceptable side effects, such as extreme drowsiness. If your breakthrough pain medicine does not relieve your breakthrough pain or if you have breakthrough pain more than 4 times a day, contact your doctor or nurse. They may need to adjust the doses of your pain medicines to help you get the best pain relief.

Can I take my chronic pain medicine and my breakthrough pain medicine at the same time during the day?

Yes, if necessary. You may have breakthrough pain just before or after taking your regular pain medicine. At such times, you should take your breakthrough pain medicine and continue to take your chronic pain medicine on schedule. Always follow the directions given to you by your doctor or nurse.

If you regularly have breakthrough pain right before your usual dose of chronic pain medicine, talk to your doctor or nurse. They may need to adjust the dose or the frequency of your chronic pain medicine. If you have any questions about when to take either your chronic or breakthrough pain medicines, contact your doctor or nurse to discuss your pain medicine schedule.

What If I Need to Change My Pain Medicine?

If one medicine or treatment does not work, there is almost always another one that can be tried. If a schedule or way that you are taking medicine does not work for you, changes can be made. Talk to your doctor or nurse about finding the pain medicine or method that works best for you. You may need a different pain medicine, a combination of pain medicines, or a change in the dose or timing of your pain medicines if:

• Your pain is not relieved. 
• Your pain medicine does not start working within the time your doctor said it would. 
• Your pain medicine does not work for the length of time your doctor said it would. 
• You have breakthrough pain more than 4 times a day, or it's getting worse, or it's not relieved with the short-acting medicine you are taking for it. 
• You have side effects. Side effects such as sleepiness, nausea, and itching usually go away after your body adjusts to the medication. Let your doctor know if these bother you. 
• You have serious side effects such as trouble breathing, dizziness, and rashes. Call your doctor right away if these occur. 
• The schedule or the way you are taking the medicine does not work for you. 
• Pain interferes with your normal activities, such as eating, sleeping, working, and sexual activity.

To help make the most of your pain control plan:

• Take your pain medicine on a regular schedule (around the clock) to help control chronic pain. Take it when it is time to take it -- even if you are not having pain. 
• Do not skip doses of your scheduled medicine. The more pain you have, the harder it is to control. 
• If you have breakthrough pain, use your short-acting medicine as your doctor suggests. Don't wait for the pain to get worse -- if you do, it may be harder to control. 
• Be sure only one doctor prescribes your pain medicine. If another doctor changes your medicine, the two doctors should discuss your treatment with each other. 
• Never take someone else's medicine. Medicines that helped a friend or relative may not be right for you. 
• Do not use old pain medicine or medicine left over from other problems. Drugs that worked for you in the past may not be right for you now. 
• Pain medicines affect different people in different ways. A very small dose may work for you, while someone else may need to take a much larger dose to obtain pain relief. 
• Remember, your pain control plan can be changed at any time.

Medicines Used to Relieve Pain

The type of medicine and the way the medicine is given depend on the type and cause of pain. For example, chronic pain is best relieved by methods that deliver a steady dose of pain medicine over a long period of time, such as a patch that is filled with medicine and placed on the skin or slow-release oral tablets. On the other hand, breakthrough pain is best treated with medicines that work fast (immediate release), but only for a short time. Below is an overview of the types of medicines used to relieve pain. More detailed explanations can be found later in this document.

For Mild to Moderate Pain

Non-opioids: Acetaminophen (Tylenol^®) and nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen.

You can buy many of these over the counter (without a prescription). For others, you need a prescription. Check with your doctor before using these medicines. NSAIDs can slow blood clotting, this may be a problem if you are having surgery or getting chemotherapy.

For Moderate to Severe Pain

Opioids (also known as narcotics): Morphine, fentanyl, hydromorphone, oxycodone, and codeine.

You need a written prescription for these medicines. Non-opioids may be used along with opioids for moderate to severe pain.

For Breakthrough Pain

Rapid-onset opioids: Immediate-release oral morphine.

You need a written prescription for these medicines. A short-acting opioid, which relieves breakthrough pain quickly, is often used with a long-acting opioid for chronic pain.

For Tingling and Burning Pain

Antidepressants: Amitriptyline, nortriptyline, and desipramine.

You need a prescription for these medicines. Antidepressants are also prescribed to relieve some types of pain. Taking an antidepressant does not mean that you are depressed or have a mental illness.

Anticonvulsants (anti-seizure medicines): Carbamazepine, gabapentin, and phenytoin

You need a prescription for these medicines. Despite the name, anticonvulsants are used not only for convulsions, but also to control burning and tingling pain.

For Pain Caused by Swelling

Steroids: Prednisone, dexamethasone.

You need a prescription for these medicines. They are used to lessen swelling, which often causes pain.

How Is Pain Medicine Given?

Some people think that if their pain becomes severe, they will need to get injections or shots of pain medicine. In fact, shots are rarely given to relieve cancer pain. There are many other ways you can take pain medicine.

• Oral -- medicine is given in a liquid, pill, capsule or transmucosal (stick you suck on) form. 
• Skin patch -- a clear, bandage-like patch placed on the skin, which slowly but continuously releases the medicine through the skin for 2 to 3 days. This form of medicine is less likely to cause nausea and vomiting. 
• Rectal suppositories-- medicine that dissolves in the rectum and is absorbed by the body.
•  Injections
• Subcutaneous (SC) injection -- medicine is placed just under the skin using a small needle.
• Intravenous (IV) injection -- medicine goes directly into the vein through a needle, port, or catheter.
• Intrathecal and epidural injections -- medicine is placed directly into the fluid around the spinal cord (intrathecal) or into the space around the spinal cord (epidural).
• Pump, or Patient-controlled analgesia (PCA) -- with this method, you can help control the amount of pain medicine you take. When you need pain relief, you can press a button to get a preset dose of pain medicine through a computerized pump that is connected to a small tube going into your body. The medicine is injected into a vein (intravenously), just under the skin (subcutaneously), or into the spinal area.

What Are the Side Effects of Pain Medicine?

Many side effects from pain medicine can be prevented. Some mild side effects that do occur, such as nausea, itching, or drowsiness, will usually go away after a few days as your body adjusts to the medicine. Let your doctor or nurse know if you are having these side effects and ask for help in managing them.

More serious side effects of pain medicine are rare. As with the more common ones, they usually happen in the first few hours of treatment. They include trouble breathing, dizziness, and rashes. If you have any of these side effects, you should call your doctor right away.

Keep in mind that you usually cannot take aspirin, ibuprofen, and other NSAIDs when you are having chemotherapy. If you are getting cancer treatment talk to your doctor before you take any non-prescription pain relievers.

Will Taking Two Different Opioid Pain Medicines Cause More Side Effects?

This is usually not a problem. In fact, long-acting and short-acting drugs are used together so that you will have fewer side effects. Most people only have breakthrough pain a few times a day and the breakthrough pain is usually much more severe than their chronic pain. By taking a short-acting medicine for breakthrough pain, you get extra medicine only when you need it. Most of the time you can expect the same types of side effects from breakthrough pain medicines as from long-acting medicines.

Which Medicines Will I Be Given?

In many cases, non-opioids are all you will need to relieve your pain, especially if you "stay on top of the pain" by taking them regularly. These medicines are stronger pain relievers than most people realize. For example, certain doses of opioids given by mouth are no more effective than two or three regular tablets of aspirin, acetaminophen, or ibuprofen.

If you do not get pain relief from non-opioids, opioids will usually give you the relief you need. Most side effects from opioids can be prevented or controlled. You should discuss taking opioids along with non-opioids with your doctor, nurse, or pharmacist. The two types of medicine relieve pain in different ways. Aspirin, acetaminophen, or ibuprofen taken four times a day might help you reduce or even avoid the need for stronger pain relievers. Many people who take opioids can benefit from continuing to take regular doses of aspirin, acetaminophen, or ibuprofen.

Some pain medicines combine an opioid and a non-opioid, like aspirin or acetaminophen, in the same pill. Ask your doctor, nurse, or pharmacist how much aspirin or acetaminophen, if any, is in your prescription. They can help you figure out how much of these medicines you can take together safely. Other classes of medicines, such as antidepressants and anticonvulsants, may also be needed to relieve certain types of cancer pain.

Non-opioids

Non-opioids control mild to moderate pain. Some can be bought without a prescription. For some examples of common non-opioids used today and their side effects, look at Table 1.

Table 1. Nonopioids -- Acetaminophen and NSAIDs

Type	Action	Side Effects
Acetaminophen (Tylenol®)	Reduces pain and fever	Large doses (more than 4 grams in 24 hours) can injure the liver or kidneys. Use by persons who have 3 or more alcoholic drinks per day may cause liver damage. Acetaminophen reduces fever, so ask your doctor what to do if your body temperature is greater than normal (98.6oF or 37oC) while you are taking this medicine.
NSAIDs (Nonsteroidal anti-inflammatory drugs)
Over the counter: Aspirin Ibuprofen (Motrin®) Ketoprofen Naproxen sodium (Aleve® or Naprosyn®) Prescription: Celecoxib Choline magnesium trisalicylate (Trisalicylate®) Diclofenac (Voltaren®) Etodolac (Lodine®) Fenoprofen calcium Indomethacin (Indocin®) Ketorolac (Toradol®) Meclofenamate sodium (Meclomen®) Nabumetone (Relafen®) Naproxen Oxaprozin (Daypro®) Piroxicam (Feldene®) Sulindac (Clinoril®) Tolmetin sodium (Tolectin®)	Reduce pain, inflammation, and fever	NSAID medicines can have the following side effects: Can irritate the stomach Can cause bleeding of the stomach lining, especially if combined with alcohol Can cause kidney problems Avoid these medications if you are on anti-cancer drugs that may cause bleeding. Aspirin and NSAIDs reduce fever, so ask your doctor about what to do if your body temperature is greater than normal (98.6oF or 37oC) while you are taking one of these medicines.

Brand-Name Drugs Versus Generic Drugs: Drugs may have as many as three different names: brand, generic, and chemical. Drug companies give their products brand names. The Food and Drug Administration (FDA) approves the generic, shortened names by which drugs are usually known. Chemical names are long and tend to be hard to pronounce. Here's an example:

Brand name: Tylenol^®
Generic name: Acetaminophen
Chemical name: N-(4-hydroxyphenyl) acetamide

Many pain relievers are available under both generic and brand names. We have included some of the more common generic names with their brand names in parentheses in Table 1. Your doctor, nurse, or pharmacist can tell you the generic and brand names of any medicines you are taking. It is always good to know both because you may hear either name when discussing your medicines. Knowing both names will also keep you from getting confused when keeping track of prescriptions and pill bottles.

Generic products usually cost less than brand-name drugs. Sometimes medicines can have the same generic name, but are produced by different companies. Because the companies may produce the medicines differently, they may differ in the way they are absorbed by the body. For this reason, your doctor may prefer that you take a brand-name drug. Ask your doctor, nurse, or pharmacist if you can use a less expensive medication. Pharmacists are careful to obtain high-quality generic products, so it is sometimes possible to make substitutions. Along with the main substance (for example aspirin, acetaminophen, or ibuprofen), some brands contain substances called additives. Common additives include:

• Buffers (such as magnesium carbonate or aluminum hydroxide) to decrease stomach upset. 
• Caffeine to act as a stimulant and lessen pain. 
• Antihistamines (such as diphenhydramine or pyrilamine) to help you relax or sleep.

Medicines with additives can cause some side effects. For example, antihistamines sometimes cause drowsiness. This may be all right at bedtime, but it could be a problem during the day. Also, additives tend to increase the cost of non-prescription pain relievers. They can also change the action of other medicines you may be taking.

Plain aspirin, acetaminophen, or ibuprofen probably works as well as the same medicines with additives. But if you find that a brand with certain additives is a better pain reliever, ask your doctor, nurse, or pharmacist if the additives are safe for you. Talk with them about any concerns you may have about the drugs contained in your non-prescription pain medicines.

Nonsteroidal Anti-inflammatory Drugs

Non-steroidal anti-inflammatory drugs (NSAIDs) are similar to aspirin. Either alone or in combination with other medicines, NSAIDs are useful in controlling pain and inflammation. Before you take any NSAIDs or other non-opioids, ask your doctor or nurse if it is safe for you to take it and how long you can take it.

Precautions when taking NSAIDs

Some people have conditions that may be made worse by NSAIDs or by any product that contains NSAIDs. In general, NSAIDs should be avoided by people who:

• Are allergic to aspirin 
• Are on chemotherapy 
• Are on steroid medicines 
• Have stomach ulcers or a history of ulcers, gout, or bleeding disorders 
• Are taking prescription medicines for arthritis 
• Are taking oral medicine for diabetes or gout 
• Have kidney problems 
• Will have surgery within a week 
• Are taking blood-thinning medicine

Be careful about mixing NSAIDs with alcohol -- taking NSAIDs and drinking alcohol can cause stomach upset and sometimes bleeding in the lining of the stomach.

Hidden Aspirin

Some opioid medicines also contain aspirin. If one of your doctors does not want you to take aspirin, be sure to read the labels carefully. If you are not sure if a medicine contains aspirin, ask your pharmacist.

Side Effects of Nonsteroidal Anti-inflammatory Drugs

The most common side effect from NSAIDs is stomach upset or indigestion, especially in older people. Taking NSAIDs with food or milk or immediately after a meal lessens your chance of stomach problems. Ask your pharmacist to tell you which NSAIDs products are less likely to upset your stomach.

NSAIDs also prevent platelets from working correctly. Platelets are the blood cells that help blood clot after an injury. When platelets don't function as they should, bleeding is more difficult to stop.

NSAIDs can also irritate the stomach and cause bleeding. If your stools become darker than normal or if you notice unusual bruising -- both signs of bleeding -- tell your doctor or nurse. Other side effects include kidney problems and stomach ulcers.

Acetaminophen

This medicine relieves pain in a way similar to NSAIDs, but it does not reduce inflammation as well as NSAIDs. People rarely have any side effects from the usual dose of acetaminophen. However, liver and kidney damage may result from using large doses of this medicine every day for a long time or drinking alcohol with the usual dose. Even moderate amounts of alcohol can lead to liver damage in people taking acetaminophen.

Your doctor may not want you to take acetaminophen regularly if you are getting chemotherapy because it can cover up a fever. The doctor needs to know about any fever because it may be a sign of infection, which needs to be treated.

Opioids

These medicines are used alone or with non-opioids to treat moderate to severe pain. Opioids are similar to natural substances (called endorphins) produced by the body to control pain. Some work better than others in relieving severe pain. These medicines were once made from the opium poppy, but today many are synthetic, that is, they are chemicals made by drug companies.

Common Opioids with Generic Name and Brand Name (in parentheses):

• Codeine 
• Hydromorphone (Dilaudid^®) 
• Levorphanol (Levo-Dromoran^®) 
• Methadone 
• Morphine 
• Oxycodone (OxyContin^®, OxyIR^®, Roxicodone^®) 
• Meperidine (Demerol^®) 
• Oxymorphone 
• Fentanyl (Duragesic^®)

Combination Opioid/NSAID preparations:

• Codeine (with aspirin or acetaminophen) 
• Oxycodone (Percodan^® or Percocet^®, Tylox^®) 
• Hydrocodone with acetaminophen (Vicodin^®, Lorcet^®)

Drug Tolerance

People who take opioids for pain sometimes find that over time they need to take larger doses. This may be due to an increase in the pain or the development of drug tolerance. Drug tolerance happens when your body gets used to the medicine you are taking, and your medicine does not relieve the pain as well as it once did. Many people do not develop a tolerance to opioids. But if tolerance does develop, usually small increases in the dose or a change in the kind of medicine will help relieve the pain.

Increasing the doses of opioids to relieve increasing pain or to overcome drug tolerance does NOT lead to addiction.

How to Get Proper Pain Relief with Opioids

When a medicine does not give you enough pain relief, your doctor may increase the dose or how often you take it. When your health care team is closely working with you, doses of strong opioids can be raised safely to ease severe pain. Do not increase the dose of your pain medicine on your own. If dose changes do not work, your doctor may prescribe a different or additional drug. Some opioids are stronger than others, and you may need a stronger one to control your pain.

If your pain relief is not lasting long enough, ask your doctor about extended-release medicines. These can control your pain for a longer period of time. Morphine and oxycodone are made in extended-release forms. Also, a skin patch that slowly releases the opioid fentanyl can be used.

If your pain is controlled most of the time, but you sometimes have breakthrough pain, your doctor may prescribe a fast-acting medicine, such as immediate-release morphine. This will give you faster pain relief right when it is needed.

Precautions When Taking Opioids

Doctors carefully watch you and adjust the doses of pain medicine so you do not take too much. For this reason, it is important that only one doctor prescribe your pain medicines. If you are working with two or more different doctors be sure that one does not prescribe opioids for you unless he or she talks to the others about it.

If you drink alcohol or take tranquilizers, sleeping aids, antidepressants, antihistamines, or any other medicines that make you sleepy, tell your doctor how much and how often you take these medicines. Combinations of opioids, alcohol, and tranquilizers can be dangerous. Even small doses may cause problems. Using such combinations can lead to overdose symptoms such as weakness, difficulty in breathing, confusion, anxiety, or more severe drowsiness or dizziness.

Side Effects of Opioids

Not everyone has side effects from opioids. The most common side effects are usually drowsiness, constipation, nausea, and vomiting. Some people might also have dizziness, itching, mental effects (such as nightmares, confusion, and hallucinations), a moderate decrease in rate and depth of breathing, or difficulty in urinating.

Drowsiness

When first you first start taking them, opioids may cause drowsiness, but this usually goes away after a few days. If your pain has kept you from sleeping, you may sleep more for a few days after beginning to take opioids while you "catch up" on your sleep. Drowsiness will also lessen as your body gets used to the medicine. Call your doctor or nurse if you still feel too drowsy for your normal activities after you have been taking the medicine for a week.

Sometimes it may be unsafe for you to drive a car, or even to walk up and down stairs alone. Avoid operating heavy equipment or performing activities that require alertness.

Here are some ways to handle drowsiness:

• Wait a few days and see if it disappears. 
• Check to see if other medicines you are taking can also cause drowsiness. 
• Ask the doctor if you can take a smaller dose more frequently or an extended-release opioid. 
• If the opioid is not relieving the pain, the pain itself may be wearing you out. In this case, better pain relief may result in less drowsiness. Ask your doctor what you can do to get better pain relief. 
• Sometimes a small decrease in the dose of an opioid will still relieve your pain without drowsiness. If the drowsiness is severe, you may be taking more opioid than you need. Ask your doctor about lowering the amount you are now taking. 
• Ask your doctor about changing to a different medicine. 
• Ask your doctor if you can take a mild stimulant such as caffeine. 
• If drowsiness is severe or if it suddenly begins to be a problem after you have been taking opioids for a while, call your doctor or nurse right away.

Constipation

Opioids cause some constipation in most people. This is because opioids slow the movement of stool through the intestinal tract which allows more time for water to be absorbed by the body. The stool then becomes hard. Constipation can often be prevented and/or controlled.

After checking with your doctor or nurse, you can try the following to prevent constipation:

• Get them to recommend a stool softener, also ask how often and how much you should take. 
• Drink plenty of liquids. Eight to ten 8-ounce glasses of fluid each day will help keep your stools soft. This is the most important step! 
• Eat foods high in fiber or roughage such as uncooked fruits (with the skin on), vegetables, and whole grain breads and cereals. 
• Add 1 or 2 tablespoons of unprocessed bran to your food. This adds bulk and stimulates bowel movements. Keep a shaker of bran handy at mealtimes to make it easy to sprinkle on foods. 
• Exercise as much as you can. 
• Eat foods that have helped relieve constipation in the past. 
• If you are confined to bed, try to use the toilet or bedside commode when you have a bowel movement, even if that is the only time you get out of bed.

If you are still constipated after trying all the above measures, ask your doctor to prescribe a stool softener or laxative. Be sure to check with your doctor or nurse before taking any laxative or stool softener on your own. If you have not had a bowel movement for 2 days or more, call your doctor.

Nausea and vomiting

Nausea and vomiting caused by opioids will usually disappear after a few days of taking the medicine. The following ideas may be helpful:

• If you have more nausea when you are up or walking around (as opposed to being in bed), stay in bed for an hour or so after you take your medicine. This type of nausea is like motion sickness. Sometimes over-the-counter medicines such as meclizine (Bonine^® or Antivert^®) or dimenhydrinate (Dramamine^®) help this type of nausea. Check with your doctor or nurse before taking these medicines. 
• If pain itself is causing the nausea, using opioids to relieve the pain usually makes the nausea go away. 
• Medicines that relieve nausea can be prescribed if you need them. 
• Ask your doctor or nurse if the cancer, some other medical condition, or other medicine you are taking such as steroids, chemotherapy drugs, or aspirin might be causing your nausea. Constipation may also contribute to nausea.

Some people think they are allergic to opioids if they cause nausea. Nausea and vomiting alone usually are not allergic responses. But a rash or itching along with nausea and vomiting may be an allergic reaction. If this happens, stop taking the medicine and tell your doctor right away.

When You No Longer Need Opioids

You should not suddenly stop taking opioids. People who stop taking opioids are usually taken off the medicine gradually so that any withdrawal symptoms will be mild or hardly noticeable. If you stop taking opioids suddenly and develop a flu-like illness, excessive sweating, diarrhea, or any other unusual reaction, tell your doctor or nurse. These symptoms can be treated and tend to disappear in a few days to a few weeks. Again, slowly decreasing your opioids over time usually keeps these kinds of reactions from happening.

Other Types of Pain Medicine

Several different types of medicines can be used along with (or instead of) opioids to relieve cancer pain. They may relieve pain or may increase the effect of opioids. Others lessen the side effects of opioids. Table 2 shows the classes of non-opioid medicines that your doctor might prescribe to help you get the best pain relief with as few side effects as possible.

Table 2. Other Medicines Commonly Used to Relieve Cancer Pain

Non-Drug Treatments for Pain

Non-drug treatments are now widely used to help manage cancer pain. Many techniques are used alone or along with pain medicine. Some people find they can take a lower dose of medicine when using these techniques. These methods include: relaxation, biofeedback, imagery, distraction, hypnosis, skin stimulation, transcutaneous electric nerve stimulation (TENS), acupuncture, exercise or physical therapy, and emotional support and counseling.

You may need the help of health professionals -- social workers, physical therapists, psychologists, nurses, or others -- to learn to use these techniques. Family and friends can also help. To find out who specializes in these techniques and which organizations are knowledgeable about them:

• Talk with your doctor or nurse. 
• Contact a local hospice, cancer treatment center, or pain clinic. 
• Visit your local bookstores or library.

You can also contact the National Center for Complementary and Alternative Medicine Clearinghouse toll free at 1-888-644-6226 or via email at info@nccam.nih.gov to learn more about these techniques.

Pain may be a sign that the cancer has spread, an infection is present, or there are problems caused by the cancer treatment. Because of this, you should report any new pain problems to the doctor or nurse before trying any non-drug treatments to relieve the pain.

Some general guidelines for relieving pain with non-drug methods include:

• Try different methods to learn which ones work for you. 
• Try using a non-medicine method along with your medicine. For instance, you might use a relaxation technique (to lessen tension, reduce anxiety, and manage pain) at the same time you take medicine. 
• Know yourself and what you can do. Often when people are rested and alert, they can use a method that demands more attention and energy. When tired, people may need to use a method that requires less effort. For example, try distraction when you are rested and alert; use hot or cold packs when you are tired. 
• Be open-minded and keep trying. Keep a record of what makes you feel better and what doesn't help.

Try each method more than once. If it doesn't work the first time, try it a few more times before you decide it is not helping you.

Relaxation

Relaxation relieves pain or keeps it from getting worse by reducing tension in the muscles. It can help you fall asleep, give you more energy, make you less tired, reduce your anxiety, and help other pain relief methods work better. Some people, for instance, find that taking pain medicine or using a cold or hot pack works faster and better when they relax at the same time.

How to Use Relaxation

Relaxation may be done sitting up or lying down. Choose a quiet place whenever possible. Close your eyes. Do not cross your arms and legs because that may cut off circulation and cause numbness or tingling. If you are lying down, be sure you are comfortable. Put a small pillow under your neck and under your knees or use a low stool to support your lower legs.

There are many relaxation methods. Here are some for you to try:

Visual Concentration and Rhythmic Massage:

• Open your eyes and stare at an object, or close your eyes and think of a peaceful, calm scene. 
• With the palm of your hand, massage near the area of pain in a circular, firm manner. Avoid red, raw, or swollen areas. You may wish to ask a family member or friend to do this for you.

Inhale/Tense, Exhale/Relax:

• Breathe in deeply. At the same time, tense your muscles or a group of muscles. For example, you can squeeze your eyes shut, frown, clench your teeth, make a fist, stiffen your arms and legs, or draw up your arms and legs as tightly as you can. 
• Hold your breath and keep your muscles tense for a second or two. 
• Let go. Breathe out and let your body go limp.

Slow Rhythmic Breathing:

• Stare at an object or close your eyes and concentrate on your breathing or on a peaceful scene.
• Take a slow, deep breath and, as you breathe in, tense your muscles (such as your arms). 
• As you breathe out, relax your muscles and feel the tension draining. 
• Now remain relaxed and begin breathing slowly and comfortably, concentrating on your breathing, taking about 9 to 12 breaths a minute. Do not breathe too deeply. 
• To maintain a slow, even rhythm as you breathe out, you can say silently to yourself, "In, one, two; out, one, two." It may be helpful at first if someone counts out loud for you. If you ever feel out of breath, take a deep breath and then continue the slow breathing. Each time you breathe out, feel yourself relaxing and going limp. If some muscles, such as your shoulder muscles, are not relaxed, tense them as you breathe in and relax them as you breathe out. Do this only once or twice for each specific muscle group. 
• Continue slow, rhythmic breathing for a few seconds up to 10 minutes, depending on your need. 
• To end your slow rhythmic breathing, count silently and slowly from one to three. Open your eyes. Say silently to yourself, "I feel alert and relaxed." Begin moving about slowly.

Other Methods You Can Add to Slow Rhythmic Breathing:

• Imagery (see section on Imagery) 
• Listening to slow, familiar music through an earphone or headset. 
• Progressive relaxation of body parts. Once you are breathing slowly and comfortably, you may relax different body parts, starting with your feet and working up to your head. Think of words such as limp, heavy, light, warm, or floating. Each time you breathe out, you can focus on a particular area of the body and feel it relaxing. Try to imagine that the tension is draining from that area. For example, as you breathe out, feel your feet and ankles relaxing; the next time you breathe out, feel your calves and knees relaxing, and so on up your body. 
• Ask your doctor or nurse to recommend commercially available relaxation tapes. These tape recordings provide step-by-step instructions in relaxation techniques.

Precautions

Some people who have used relaxation for pain relief have reported the following problems and have suggested the following solutions:

• Relaxation may be difficult to use with severe pain. If you have this problem, use quick and easy relaxation methods such as visual concentration with rhythmic massage or breathe in/tense, breathe out/relax. 
• Sometimes breathing too deeply for a while can cause shortness of breath. If this happens to you, take shallow breaths and/or breathe more slowly. 
• You may fall asleep. This can be especially helpful if you are ready to go to bed. If you do not wish to fall asleep, sit in a hard chair while doing the relaxation exercise or set a timer or alarm.

If you have trouble using these methods, ask your doctor, nurse, social worker, or pain specialist to refer you to someone who is experienced in relaxation techniques. Do not continue any technique that increases your pain, makes you feel uneasy, or causes unpleasant effects.

Biofeedback

Learning this technique requires the help of a licensed biofeedback technician. With the help of special machines, people can learn to control certain body functions such as heart rate, blood pressure, and muscle tension. Biofeedback is sometimes used to help people learn to relax. You can use biofeedback techniques to help you relax and to help you cope with pain. This technique is usually used with other pain relief methods.

Imagery

Imagery is using your imagination to create mental pictures or situations. The way imagery relieves pain is not completely understood. Imagery can be thought of as a deliberate daydream that uses all of your senses -- sight, touch, hearing, smell, and taste. Some people believe that imagery is a form of self-hypnosis.

Certain images may reduce your pain both during imagery and for hours afterward. If you must stay in bed or can't leave the house, you may find that imagery helps you feel less closed-in; you can imagine and revisit your favorite spots in your mind. Imagery can help you relax, relieve boredom, decrease anxiety, and help you sleep.

How to use imagery

Imagery usually works best with your eyes closed. You may want to use a relaxation technique before using imagery. The image can be something like a ball of healing energy or a picture drawn in your mind of yourself as a person without pain. (For example, imagine that you are cutting the wires that send pain signals from each part of your body to your brain.) Or think of a pleasant, safe, relaxing place or activity that has made you happy. Exploring this place or activity in your mind can help you feel calm.

Here is an exercise with the ball of energy.

• Close your eyes. Breathe slowly and feel yourself relax. 
• Concentrate on your breathing. Breathe slowly and comfortably from your abdomen. As you breathe in, say silently and slowly to yourself, "In, one, two." As you breathe out, say, "Out, one, two." Breathe in this slow rhythm for a few minutes. 
• Imagine a ball of healing energy forming in your lungs or on your chest. It may be like a white light. It can be vague--it does not have to be clear or vivid. Imagine this ball forming, taking shape. 
• When you are ready, imagine that the air you breathe in blows this healing ball of energy to the area of your pain. Once there, the ball heals and relaxes you. 
• When you breathe out, imagine the air blows the ball away from your body. As it goes, the ball takes your pain with it. 
• Repeat the last two steps each time you breathe in and out. 
• You may imagine that the ball gets bigger and bigger as it takes more and more discomfort away from your body. 
• To end the imagery, count slowly to three, breathe in deeply, open your eyes, and say silently to yourself, "I feel alert and relaxed." Begin moving about slowly.

Problems that may occur with imagery are similar to the ones that occur with the relaxation techniques.

Distraction

Distraction means turning your attention to something other than the pain. People use this method without realizing it when they watch television or listen to the radio to take their minds off a worry or their pain.

Distraction may be used alone to manage mild pain or used with medicine to manage brief episodes of severe pain, such as pain related to procedures. Distraction is useful when you are waiting for pain medicine to start working. If the pain is mild, you may be able to distract yourself for hours. Distraction can be a powerful way of relieving even the most intense pain for awhile.

How to use distraction

Any activity that occupies your attention can be used for distraction. Distractions can be internal, such as counting, singing mentally to yourself, praying, or repeating statements in your head such as "I can cope." Or distractions can be external, for example, doing crafts such as needlework, model building, or painting. Losing yourself in a good book might divert your mind from the pain. Going to a movie, watching television, or listening to music are also good distraction methods. Slow, rhythmic breathing can be used as distraction as well as relaxation. Visiting with friends or family is another useful distraction technique.

You may find it helpful to listen to rather fast music through a headset or earphones. To help keep your attention on the music, tap out the rhythm. You can adjust the volume to match the intensity of the pain, making it louder for very severe pain. This technique does not require much energy, so it may be very useful when you are tired.

After using a distraction technique, some people report that they are tired, irritable, and feel more pain. If this is a problem for you, you may not want to use distraction or you might want to be careful about which distraction methods you use and when you use them.

Hypnosis

Hypnosis is the trance-like state of high concentration between sleeping and waking. In this relaxed state, a person becomes more receptive or open to suggestion. Hypnosis can be used to block the awareness of pain, to substitute another feeling for the pain, and to change the sensation to one that is not painful. You can be hypnotized by a person trained in hypnosis, often a psychologist or psychiatrist. You can also be trained to hypnotize yourself.

During hypnosis, many people feel much like we do when we begin to awaken in the morning. We can't quite open our eyes, but are very aware. We can hear sounds inside or outside our house. Our eyes remain closed, and we feel as though we either can't or don't want to wake up and open our eyes.

A trained hypnotherapist can teach people to put themselves in a hypnotic state, make positive suggestions to themselves, and to leave the hypnotic state.

Choose a hypnotherapist who is licensed in the healing arts or who works under the supervision of someone who is licensed. To locate a therapist skilled in hypnosis, contact the behavioral medicine department at a cancer center near you.

Skin Stimulation

In this series of techniques, the skin is stimulated so that pressure, warmth, or cold is felt, but the feeling of pain is lessened or blocked. Massage, pressure, vibration, heat, cold, and menthol preparations are used to stimulate the skin. These techniques also change the flow of blood to the area that is stimulated. Sometimes skin stimulation will get rid of pain or lessen pain during the stimulation and for hours after it is finished.

Skin stimulation is done either on or near the area of pain. You can also use skin stimulation on the side of the body opposite the pain. For example, you might stimulate the left knee to decrease the pain in the right knee. Stimulating the skin in areas away from the pain can be used to increase relaxation and may relieve pain.

Precautions

If you are having radiation therapy, check with your doctor or nurse before using skin stimulation. If you are getting chemotherapy, check with your doctor before using hot or cold packs. You should not apply ointments, salves, or liniments to the treatment area, and you should not use heat or extreme cold on treated areas.

Massage

Using a slow, steady, circular motion, massage over or near the area of pain with just your bare hand or with any substance that feels good, such as talcum powder, warm oil, or hand lotion. Depending on where your pain is located, you may do it yourself or ask a family member, friend, or a massage therapist to give you a massage. Some people find brushing or stroking lightly more comforting than deep massage. Use whatever works best for you.

Precaution: If you are having radiation therapy, avoid massage in the treatment area as well as red, raw, tender, or swollen areas.

Pressure

To use pressure, press on various areas over and near your pain with your entire hand, the heel of your hand, your fingertip or knuckle, the ball of your thumb, or by using one or both hands to encircle your arm or leg. You can experiment by applying pressure for about 10 seconds to see if it helps. You can also feel around your pain and outward to see if you can find "trigger points," small areas under the skin that are especially sensitive or that trigger pain. Pressure usually works best if it is applied as firmly as possible without causing more pain. You can use pressure for up to 1 minute. This often will relieve pain for several minutes to several hours after the pressure is released.

Vibration

Vibration over and near the area of the pain may bring short-term relief. For example, the scalp attachment of a hand-held vibrator often relieves a headache. For low back pain, a long, slender battery-operated vibrator placed at the small of the back may be helpful. You may use a vibrating device such as a small battery operated vibrator, a hand-held electric vibrator, a large heat-massage electric pad, or a bed vibrator.

Precautions: If you are having radiation therapy, avoid vibration in the treatment area. Do not use a vibrator on the stomach. Avoid vibration over red, raw, tender, or swollen areas.

Cold or Heat

As with any of the techniques described, you should use what works best for you. Heat often relieves sore muscles; cold lessens pain sensations by numbing the painful area. You can also alternate heat and cold for added relief in some cases.

For cold, try gel packs that are sealed in plastic and remain soft and flexible even when frozen. You can get gel packs at drugstores and medical supply stores. They can be used again and stored in the freezer. You may want to wrap the pack in a towel to make it more comfortable. An ice pack, ice cubes wrapped in a towel, or water frozen in a paper cup also work.

Precautions: If you start to shiver when using cold, stop right away. Do not use cold so intense or for so long that the cold itself causes more pain.

To use heat for pain relief, a heating pad that generates its own moisture is convenient. You can also try gel packs heated in hot water; hot water bottles; a hot, moist towel; a regular heating pad; a hot bath or shower; or a hot tub to apply heat.You might want to try one of the heat patches you can buy at the drugstore. For aching joints, such as elbows and knees, wrap the joint in a lightweight plastic wrap (tape the plastic to itself). This retains body heat and moisture.

• Do not use a heating pad on bare skin. Do not go to sleep for the night with the heating pad turned on. Also, be very careful, if you are taking medicines that make you sleepy or if you do not have much feeling in the area. 
• Do not use heat over a new injury because heat can increase bleeding -- wait at least 24 hours. 
• Avoid heat or cold over any treatment area receiving radiation therapy and for 6 months after therapy has ended. 
• If you are getting chemotherapy, check with your doctor before using a cold pack. 
• Do not use heat or cold over any area where your circulation or sensation is poor. 
• Do not use heat or cold application for more than 5 to 10 minutes at a time.

Menthol

Many menthol preparations are available for pain relief. There are creams, lotions, or gels that contain menthol. When they are rubbed into the skin, they increase blood circulation to the affected area and produce a warm (or sometimes cool) soothing feeling that lasts for several hours.

To use menthol preparations, test your skin by rubbing a small amount of the substance in a circle about the size of a quarter in the area of the pain (or the area to be stimulated). This will let you know whether menthol is uncomfortable to you or irritates your skin. If the menthol does not create a problem, rub some more into the area. The feeling from the menthol slowly increases and remains up to several hours. If you are concerned about the odor, you can use the menthol when you are alone or perhaps in the evening or over night.

Precautions

• Do not rub menthol near your eyes, over broken skin, a skin rash, or mucous membranes (such as inside your mouth, or around your genitals and rectum).

• Make sure you do not get menthol in your eyes. (Wash your hands after applying menthol.)

• Do not use menthol in the treatment area during radiation therapy.

• If you have been told not to take aspirin, do not use these preparations until you check with your doctor. Many menthol preparations contain an additional ingredient similar to aspirin. A small amount of this aspirin-like substance may be absorbed through the skin.

Transcutaneous Electric Nerve Stimulation (TENS)

This is a technique in which mild electric currents are applied to some areas of the skin by a small power pack connected to two electrodes. The feeling is described as a buzzing, tingling, or tapping feeling. The small electric impulses seem to interfere with pain sensations. The current can be adjusted so that the sensation is pleasant and relieves pain. Pain relief lasts beyond the time that the current is applied. Your doctor or a physical therapist can tell you where to get a TENS unit, and how to use it properly.

Acupuncture

In acupuncture, thin needles are inserted into the body at certain points and at various depths and angles. Each point controls the pain sensation of a different part of the body. When the needle is inserted, a slight ache, dull pain, tingling, or electrical sensation is felt for a few seconds. Once the needles are in place, there should be no further discomfort. The needles are usually left in place for between 15 and 30 minutes, depending on the condition treated. No discomfort is felt when the needles are removed. Acupuncture is now a widely accepted and proven method of pain relief. Acupuncture should be performed by a licensed acupuncturist. Ask your doctor, nurse, or social worker where to get acupuncture.

Precautions

• Make sure your acupuncturist uses sterile needles. 
• If you are getting chemotherapy, talk to your doctor before beginning acupuncture.

Emotional Support and Counseling

If you feel anxious or depressed, your pain may seem worse. Pain also can make you feel worried, depressed, or easily discouraged. Some people feel hopeless or helpless. Others may feel embarrassed, inadequate, angry, frightened, isolated, or frantic. These are all normal feelings.

Finding support

Try to talk about your feelings with someone you feel comfortable with -- doctors, nurses, social workers, family or friends, a member of the clergy, or other people with cancer. You may also wish to talk to a counselor or a mental health professional. Your doctor, nurse, or the social services department at your local hospital can help you find a counselor who is specially trained to help people with chronic illnesses.

You may want to try a support group where people with cancer meet and share their feelings about how they have coped with cancer. Support groups can be face-to-face meetings or you can meet in a group online. For information about support groups in your community and online, ask your doctor, nurse, or hospital social worker or call ACS at 1-800-ACS-2345. Also, many newspapers carry a special health supplement containing information about where to find support groups.

Other Pain Relief Methods

Some people have pain that is not relieved by medicine or non-drug techniques. In these cases, other treatments can be used to reduce pain.

Radiation Therapy

Treatment with high-energy rays (called radiation therapy) can reduce pain by shrinking a tumor. Often, only a single dose of radiation is needed to relieve pain.

Surgery

Pain cannot be felt if the nerve pathways that carry pain impulses to the brain are interrupted. To block these pathways, a neurosurgeon may cut nerves, usually near the spinal cord. When the nerves that relay pain are destroyed, the sensations of pressure and temperature can no longer be felt. Surgeons with special skills and expertise in pain management, preferably in consultation with other pain specialists, should perform these procedures.

Nerve Blocks

A nerve block is a procedure where a local anesthetic, which may be combined with a steroid, is injected into or around a nerve or into the spine to block pain. After the injection, the nerve is no longer able to relay pain so the pain is temporarily relieved. For longer lasting pain relief, phenol or alcohol can be injected. A nerve block may cause muscle paralysis or a loss of all feeling in the affected area.

Research on Pain Control Methods

Patient studies -- called clinical trials -- have helped lower cancer death rates in the United States. Clinical trials have also led to better pain control methods, such as continuous pain-medication infusion pumps (patient-controlled analgesia), which were first developed in the early 1980s.

In cancer research, a clinical trial is designed to show how a new cancer strategy -- for instance, a promising drug, a new diagnostic test, or a possible way to prevent cancer -- affects the people who receive it. These studies are the final step in the process of developing new drugs and other ways to fight diseases.

Clinical trials are being done to look for better ways to manage cancer pain. For more information about current research on pain control methods, contact the American Cancer Society or the National Cancer Institute.

The American Cancer Society offers a clinical trials matching service that can help you find a clinical trial that is right for you. You can reach this service at 1-800-303-5691 or on our Web site, http://clinicaltrials.cancer.org. From the information you give about your cancer type, stage, and previous treatments, this service compiles a list of clinical trials that match your medical needs. The service will also ask where you live and whether you are willing to travel so that it can look for a treatment center you can get to.

You can also get a list of current clinical trials by calling the National Cancer Institute’s Cancer Information Service toll free at 1-800-4-CANCER (1-800-422-6237) or by visiting the NCI clinical trials Web site at http://www.cancer.gov/clinical_trials/.

Additional Resources

More Information From Your American Cancer Society

We have selected some related information that may also be helpful to you. These materials may be viewed on our Web site or ordered from our toll-free number, 1-800-ACS-2345.

A Message of Hope: Coping With Cancer in Everyday Life

NCCN Cancer Pain Treatment guidelines for Patients (also available in Spanish)

Caring For The Patient With Cancer At Home: A Guide For Patients and Families (also available in Spanish)

Health Professionals Associated With Cancer Care

National Organizations and Web Sites*

In addition to the American Cancer Society, information about cancer and pain is available from many sources, including the ones listed here.

American Pain Foundation
Toll-free: 1-888-615-7246
Web site: http://www.painfoundation.org
Assistance in locating trained specialists and peer support is provided. The Web site gives comprehensive patient information on pain and provides an extensive online support group program.

National Cancer Institute (NCI)
Cancer Information Service (CIS)
Toll-free: 1-800-4-CANCER (1-800 422-6237)
TTY: 1-800-332-8615
Web site: http://www.cancer.gov
Provides accurate, up-to-date information on cancer to patients and their families, health professionals, and the general public. Information specialists translate the latest scientific information into understandable language and respond in English, Spanish, or on TTY equipment.

National Center for Complementary and Alternative Medicine (NCCAM)
Toll-free: 1-888-644-6226
TTY: 1-866-464-3615
Web site: http://nccam.nih.gov
Part of the National Institutes of Health (NIH), NCCAM facilitates research and evaluation of complementary and alternative medicine (CAM) healing practices and distributes this information to the public.

*Inclusion on this list does not imply endorsement by the American Cancer Society.

Please call 1-800-ACS-2345 any time, any day you have questions or need help. The American Cancer Society has information, resources, and support available on any cancer-related topic.

Glossary

Acupuncture: fine needles are inserted into the skin at certain points of the body to relieve pain.

Acute pain: pain that is severe, but lasts a relatively short time.

Addiction: uncontrollable drug craving, seeking, and use.

Analgesics: medicines that are used to relieve pain.

Anesthesiologist: a doctor who specializes in giving medicines or other agents that prevent or relieve pain.

Anticonvulsants: anti-seizure medicine, also used to control burning and tingling pain.

Antidepressant: a medicine used to treat depression or tingling or burning pain from damaged nerves.

Anxiolytic (or anti-anxiety medication): a medicine used to treat anxiety or muscle spasms.

Biofeedback: a method of learning to control certain body functions such as heartbeat, blood pressure, and muscle tension with the help of a special machine. This method can help control pain.

Breakthrough pain: moderate to severe pain that "breaks through" or is felt for a short time.

Chemotherapy: treatment with anti-cancer drugs.

Chronic pain: pain that can range from mild to severe and is present for a long time. Also called persistent pain.

Distraction: a pain relief method that takes the attention away from the pain.

Dose: the amount of medicine taken.

Epidural: an injection into the spinal column, but outside of the spinal cord.

Generic: official names by which medicines are known.

Hypnosis: a person enters into a trance-like state, becomes more aware and focused, and is more open to suggestion.

Imagery: a person thinks of pleasant images or scenes, such as waves hitting the beach, to help them relax.

Infusion: a method of giving pain medication into a vein; unlike an injection, which is pushed in by a syringe, an infusion flows in by gravity or a mechanical pump.

Intramuscular (IM): into a muscle.

Intrathecal (IC): into fluid around the spinal cord.

Intravenous (IV): into a vein.

Local anesthetic: a medicine that blocks the feeling of pain in a specific location in the body.

Narcotic: see opioids.

Nerve block: pain medicine is injected directly into or around a nerve or into the spine to block pain.

Neurologist: a doctor who specializes in treating conditions associated with the brain, nerves, and spinal cord.

Neurosurgeon: a doctor who specializes in operations on the brain, nerves, and spinal cord.

Non-opioids: acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen.

Non-prescription: over-the-counter pain relievers that can be bought without a doctor's prescription.

NSAIDs (Nonsteroidal anti-inflammatory drugs): medicines that control mild to moderate pain and inflammation. Can be used either alone or in combination with other medicines.

Oncologist: a doctor who specializes in the treatment of cancer.

Onset of action: the length of time it takes for a medicine to start to work.

Opioids: also known as narcotics. The strongest pain relievers available. A prescription is needed for these medicines.

Pain threshold: the point at which a person becomes aware of pain.

Patient-controlled analgesia (PCA): a method in which a person with pain controls the amount of pain medicine that is taken. When pain relief is needed, the person can receive a preset dose of pain medicine by pressing a button on a computerized pump that is connected to the body by a small tube.

Phantom limb pain: when pain or other unpleasant feelings are felt in the missing (phantom) part of the body or limb.

Physical therapy: a treatment for pain in muscles, nerves, joints, and bones with exercise, electrical stimulation, hydrotherapy, and the use of massage, heat, cold, and electrical devices.

Prescription: a doctor's order.

Radiation therapy: treatment with high-energy radiation to kill or control cancer cells.

Rapid-onset opioids: an opioid that relieves pain quickly.

Relaxation techniques: methods used to lessen tension, reduce anxiety, and manage pain.

Side effect: problems caused by a medicine or procedure, such as constipation or drowsiness.

Skin patch: a bandage-like patch that releases medicine through the skin and then into the bloodstream. The medicine enters the blood slowly and steadily over time.

Skin stimulation: to stimulate the skin through pressure, friction, temperature change, or chemical substances. With such stimulation, the feeling of pain can be lessened or blocked.

Stage: the extent or amount of cancer that is present.

Steroids: medicines that decrease swelling.

Subcutaneous injection (sub-Q): under the skin.

Revised: 10/23/2007