|
Many terms are used to describe smokeless tobacco products,
such as
oral, chewing, snuff, spit, and spitless tobacco. All forms of oral
tobacco have chemicals known to cause cancer (carcinogens). These
products can cause cancer of the mouth, pancreas, and esophagus (the
tube that carries food from the mouth to the stomach). Oral and
smokeless tobacco also cause many other health problems, such as gum
disease, destruction of the bone sockets around the teeth, and tooth
loss. They cause bad breath and stained teeth, too.
Smokeless tobacco is less lethal than cigarettes, but using
any form
of tobacco puts you at serious health risks. Smokeless tobacco is not a
safe alternative to smoking. The bottom line: All forms of tobacco can
be deadly.
Smokeless tobacco facts
What is smokeless tobacco?
There are 2 basic forms of smokeless tobacco: snuff and
chewing tobacco. But other forms of smokeless tobacco are also sold.
Snuff is finely ground tobacco packaged in cans or pouches. It
is sold as dry or moist. Moist snuff is used by placing a pinch, dip, lipper, or quid,
between the lower lip or cheek and gum. The nicotine in the snuff is
absorbed through the tissues of the mouth. Moist snuff is also
available in small, teabag-like pouches or sachets that can be placed
between the cheek and gum. These are designed to be both "smoke-free"
and "spit-free" and are marketed as a discreet way to use tobacco.
Dry snuff is sold in a powdered form and is used by sniffing
or inhaling the dry snuff powder up the nose.
Chewing tobacco
comes as long strands of loose leaves, plugs, or twists of tobacco.
Pieces, commonly called plugs,
wads, or chew,
are chewed or placed between the cheek and gum or teeth. The nicotine
in the piece of chewing tobacco is absorbed through the mouth tissues.
The user spits out the brown juice – saliva that soaked
through
the tobacco.
Smokeless
tobacco products also
come in other forms. Snus (sounds like snoose) is a form of moist snuff
commonly used in Sweden and Norway. It is now being marketed in the
United States. It is made of air-cured tobacco, water, salt, and
flavorings. Snus is most commonly packaged in small pouches, but can
also be used like loose moist snuff. A 2004 study showed that people
who switch to Swedish snus have smaller amounts of certain
cancer-causing agents in their bodies than those who use the more
common smokeless products. But those who used snus still had notably
higher levels of these cancer-causing agents than people who used
nicotine replacement patches. And studies have found that, in general,
snus contains higher levels of tobacco-specific nitrosamines than
cigarette smoke. (Tobacco-specific nitrosamines are chemicals known to
cause cancer.)
Other smokeless products can be bought in the United States.
Some
that are available or are being tested include lozenges, tabs, tablets,
strips, and sticks.
Marketing of smokeless tobacco products
Tobacco companies have responded to the popular laws that ban
smoking in public places by making and selling smokeless products that
can be used in no-smoking settings. They use ad slogans such as
"Anytime. Anywhere" and "No Smoking, No Problem" to target smokers who
crave nicotine while they are in smoke-free settings. Free samples and
coupons are also offered to encourage people to try these new products.
Without smokeless products, these smokers might be motivated to quit
smoking completely.
The tobacco industry is also promoting the idea that switching
to
smokeless products is a good way to quit smoking. These claims are
implied rather than stated outright, to avoid having these products
regulated as drugs. There is no proof that smokeless tobacco products
can actually help smokers quit. But there are proven treatments for
tobacco addiction, such as nicotine replacement products,
antidepressants, nicotine receptor blockers, and behavioral therapies.
These standard treatments have been carefully tested and have been
proven to help people quit smoking.
New laws will affect tobacco marketing
The Family Smoking Prevention and Tobacco Control Act went
into
effect in October 2009. This law gives the Food and Drug Administration
(FDA) power to regulate tobacco products in the U.S. One of the goals
of the law is to restrict the marketing and advertising of tobacco
products -- including smokeless tobacco products. Colorful ads and
store displays will no longer be permitted. Only black and white text
ads will be allowed. And starting in 2010, all outdoor tobacco ads
within 1,000 feet of schools and playgrounds will be illegal.
Under the law, new smokeless tobacco and other products
claiming to
have lower health risks will have to be approved by the FDA. They will
only be allowed if makers can show that the product would not encourage
many non-smokers or would-be quitters to try them, rather than not
using tobacco at all.
What are the risks of using smokeless
tobacco?
Smokeless tobacco products are not a safe substitute for
tobacco smoking. Harmful health effects include:
- oral (mouth) and throat cancer
- cancer in the esophagus (the swallowing tube that goes from
your mouth to your stomach)
- stomach cancer
- pancreatic cancer
- increased risk of heart disease, heart attacks, and stroke
- addiction to nicotine
- leukoplakia (white sores in the mouth that can become
cancer)
- receding gums (gums slowly shrink from around the teeth)
- bone loss around the roots of the teeth
- abrasion (scratching and wearing down) of teeth
- tooth loss
- stained teeth
- bad breath
Leukoplakia is a white sore or patch in the mouth that can
become
cancer. Study after study has found high rates of leukoplakia at the
place in the mouth where users place the "chew." One study found that
almost 3 of 4 of daily users of moist snuff and chewing tobacco had
non-cancerous or pre-cancerous lesions (sores) in the mouth. The longer
you use oral tobacco, the more likely you are to have leukoplakia.
Tobacco can irritate or destroy gum tissue. Many regular
smokeless
tobacco users have receding gums, gum disease, tooth decay, and bone
loss around the teeth. The surface of the tooth root may be exposed
where gums have shrunken. All this can cause teeth to loosen and fall
out.
Smokeless tobacco may also play a role in heart disease and
high
blood pressure. Results from a large American Cancer Society study
showed that men who switched from cigarettes to snuff or chewing
tobacco had higher death rates from heart disease, stroke, cancer of
the mouth and lung, and all causes of death combined than former
smokers who stopped using all tobacco products. It is unclear whether
the heart disease was caused by the smokeless tobacco products in this
study, because there have been few large, long-term studies to identify
all of the health problems caused by these products.
The snuff and chewing tobacco products most widely used in the
United States have very high levels of cancer-causing agents
(carcinogens) called tobacco-specific nitrosamines. These carcinogens
cause lung cancer in animals, even when injected into their blood.
How do the risks of using smokeless tobacco
compare with cigarette smoking?
Smokeless tobacco products are less lethal than cigarettes.
But even
though they are marketed as a less harmful alternative to smoking,
these products can be deadly. And they have not been proven to help
smokers quit. Smokers who delay quitting by using smokeless products
between cigarettes greatly increase their risk of lung cancer. They
also set themselves up for new health problems caused by smokeless
tobacco.
Who uses smokeless tobacco?
The 2007 data from the U.S. Centers for Disease Control and
Prevention (CDC) showed that about 3% of adults aged 26 and older were
current users of smokeless tobacco. About 5% of people aged 18 to 25
were current users.
But rates among younger people are even higher. According to
the
CDC's 2007 survey, more than 13% of male high school students and more
than 2% of female high school students were using smokeless tobacco.
The CDC 2006 Youth Tobacco Survey reported that, 4% of the boys and 1%
of the girls in middle school reported using smokeless tobacco at least
once in the 30 days before the survey.
Certain factors seem to be linked to whether or not young
people will use tobacco. They include:
- peer pressure
- local lifestyles and fashions
- general attitudes toward authority
- economic conditions
- examples set by teachers and school staff
- presence of gangs
- use of illegal drugs and alcohol
In 2003, more than 1 in 3 major league baseball players used
smokeless tobacco, mainly moist snuff. Athletes are the largest
marketing source for smokeless tobacco, and are often seen on TV using
it during a game. They have a lot of negative influence as role models
for youth.
A more recent influence on the use of smokeless tobacco is the
smoking bans many states are enforcing. In light of these bans, tobacco
companies have been putting new marketing emphasis on their smokeless
tobacco products. Smokeless tobacco products are being advertised as
alternatives to cigarettes in places where smoking is not allowed. When
smokers use these products as substitutes instead of trying to quit, it
supports the tobacco industry.
Smokers who put off quitting by using smokeless tobacco for a
nicotine fix while in smoke-free settings do not decrease their lung
cancer risk. They are still using tobacco and still smoking cigarettes.
Lung cancer risk is affected most by how long a person smokes.
Quitting smokeless tobacco
Quitting smokeless tobacco is not easy, but you can do it. To
have
the best chance of quitting and staying quit, you need to know what
you're up against, what your options are, and where to go for help.
Surveys show that most people who use snuff or chew would like
to
quit. In one survey, more than half of those who took part said they
would try to quit in the next year.
In many ways, quitting smokeless tobacco is a lot like
quitting
smoking. Both involve tobacco products that contain nicotine, and both
involve the physical, mental, and emotional parts of addiction. Many of
the ways to handle the mental hurdles of quitting are the same. But
there are 2 parts of quitting that are unique for oral tobacco users:
- There is often a stronger need for oral substitutes (having
something in the mouth) to take the place of the chew, snuff, or pouch.
- Mouth sores often slowly go away and gum problems caused by
the
smokeless tobacco may stop getting worse. This is a benefit of quitting
that everyone can see.
Why quit?
There are many reasons to stick it out through withdrawal and
quit
using smokeless tobacco for good. Health reasons are the obvious ones.
But consider the following as well.
Social acceptance
Chewing and dipping carry a heavy social price, especially
when
dating. Bad breath, gum disease, and stained teeth are very
unappealing. The spitting you have to do with most smokeless tobacco is
not pretty, either.
Cost
A tobacco habit can cost a lot of money. It isn't hard to
figure out
how much you spend on tobacco: multiply how much money you spend on
tobacco every day by 365 (days a year). The amount may surprise you.
Now multiply that by the number of years you have been using tobacco
and that amount will probably astound you.
Multiply the cost per year by 10 (for the next 10 years) and
ask
yourself what you would rather do with that much money. Do you really
want to continue wasting your money with nothing to show for it except
possible health problems?
Setting an example
If you have children in your life, you should want to set a
good
example for them. When asked, nearly all smokeless tobacco users say
they don't want their children to chew or dip. You can become a good
role model for them if you quit now.
Why is it so hard to quit?
Nicotine
Nicotine is a drug found naturally in tobacco. It is as
addictive as
heroin or cocaine. Over time, a person becomes physically and
emotionally addicted to (dependent on) nicotine. Studies have shown
that tobacco users must deal with both the physical and psychological
(mental) dependence to quit and stay quit.
Where nicotine
goes and how long it stays: Nicotine
enters the bloodstream from the mouth and is carried throughout the
body. It affects many parts of the body, including your heart and blood
vessels, your hormones, the way your body uses food (your metabolism),
and your brain. During pregnancy, nicotine freely crosses the placenta
and has been found in amniotic fluid and the umbilical cord blood of
newborn infants.
Different factors affect how quickly the body gets rid of
nicotine
and its by-products. Regular oral tobacco users will still have
nicotine or its by-products, such as cotinine, in their bodies for
about 3 or 4 days after stopping.
How nicotine
hooks smokers:
Nicotine causes pleasant feelings that make the tobacco user want to
use more. It also acts as a kind of depressant by interfering with the
flow of information between nerve cells. As the nervous system adapts
to nicotine, tobacco users tend to increase the amount of tobacco they
use. This raises the amount of nicotine in their blood, as more tobacco
must be used to get the same effect. This is called tolerance. Over
time, the tobacco user reaches a certain nicotine level and then keeps
up the usage to stay at this level of nicotine.
Smokeless tobacco delivers a high dose of nicotine. An average
dose
from snuff is 3.6 milligrams (mg) and from chewing tobacco is 4.5 mg
– compared with 1 to 2 mg from one cigarette. Despite this
difference, blood levels of nicotine throughout the day are much the
same among smokers and those who use smokeless tobacco.
Nicotine withdrawal: Stopping or cutting back on smokeless
tobacco
use causes symptoms of nicotine withdrawal that are much like those
smokers get when they quit. In a Swedish study, oral snuff users
reported having as much trouble giving up tobacco as cigarette smokers
did trying to quit smoking. Studies also suggest that when regular
snuff users can't use snuff, they will smoke cigarettes or use another
form of tobacco to satisfy their need for nicotine.
Withdrawal from nicotine is both physical and mental.
Physically,
the body is reacting to the absence of nicotine. Mentally and
emotionally, the user is faced with giving up a habit, which calls for
a major change in behavior. Both the physical and mental factors must
be dealt with to quit and stay quit.
Those who have used tobacco regularly for a few weeks or
longer, and
suddenly stop or greatly reduce the amount used, will have withdrawal
symptoms. Symptoms usually start within a few hours of the last dip or
chew and peak about 2 to 3 days later when most of the nicotine and its
by-products are out of the body. Withdrawal symptoms can last for a few
days to up to several weeks. They will get better every day that you
stay tobacco-free.
Withdrawal symptoms can include any of the following:
- dizziness (which may last only 1 or 2 days after quitting)
- depression
- feelings of frustration, impatience, and anger
- anxiety
- irritability
- trouble sleeping (including trouble falling asleep and
staying asleep, and having bad dreams or even nightmares)
- trouble concentrating
- restlessness
- headaches
- tiredness
- increased appetite
These uncomfortable feelings can lead you to start using
tobacco
again to boost blood levels of nicotine and stop symptoms. For
information on coping with withdrawal, please see the section "How to quit."
Help with psychological addiction
Some people are able to quit on their own, without the help of
others or the use of medicines. But for many tobacco users, it can be
hard to break the social and emotional ties to chewing or dipping while
getting over nicotine withdrawal symptoms at the same time. The good
thing is, there are many sources of support out there -- both formal
and informal.
Telephone-based help programs
As of 2009, all 50 states and the District of Columbia offer
some
type of free telephone-based quitting program, which links callers with
trained counselors. These specialists help plan a quit method that fits
each person's own pattern of tobacco use. With guidance from a
counselor, quitters can avoid common mistakes that may make it harder
to quit.
Many people find that telephone counseling is easier to use
than
some other support programs. You don't have to leave home or get child
care, and you can do it on nights and weekends. Counselors may suggest
a combination of methods including local classes, self-help brochures,
medicines, and/or a network of family and friends. One review of
studies about smokeless tobacco use found that telephone counseling
helped people trying to quit.
Support from family, friends, and quit
programs
Many former tobacco users say a support network of family and
friends was very important during their quit attempt. Other people who
may offer support and encouragement are co-workers, your family doctor
or dentist, and members of support groups for quitters. Check the "National
organizations and Web sites"
section for information on Nicotine Anonymous. Ask your employer,
health insurance company, or local hospital to help you find support
groups; or call and ask us at 1-800-227-2345.
Don't neglect this vital part of quitting. Surround yourself
with
other people who don't use tobacco, and tell them about your plans to
quit. Warn them that you might not be your usual self for a few days,
and ask them to listen and encourage you when you need it. Suggest ways
they can help, like going for a walk with you, helping you stay busy,
and reminding you that you can do this. If they've quit, ask them how
they did it and get some tips.
If you have close friends who still use tobacco, ask them not
to
offer any to you. You're not asking them to quit themselves, but you
may not want to spend a lot of time with those who still use tobacco
for the first few weeks after you quit. You may find it hard to be with
them without being tempted. But if your plan happens to inspire someone
to quit with you, you can help and support each other.
What to look for in a tobacco cessation
group or class
Tobacco cessation or quit programs are set up to help users
recognize and cope with problems that come up during quitting. They
also provide support and encouragement in staying quit. Many programs
focus mainly on smokers, but most are open to smokeless tobacco users,
too.
Studies have shown that the best programs will include either
one-on-one or group counseling. There is a strong link between how
often and how long counseling lasts (its intensity) and the success
rate. As a rule, the more intense the program the greater the chance of
success.
Intensity may be increased by having more or longer sessions
or by
increasing the number of weeks over which the sessions are given. So
when looking for a program, try to find one that has the following:
- each session lasts at least 15 to 30 minutes
- there are at least 4 sessions
- the program lasts at least 2 weeks -- longer is usually
better
Make sure the leader of the group has training in tobacco
cessation.
Some communities have a Nicotine Anonymous group that holds
regular
meetings. This group applies the 12-step program and other principles
of Alcoholics Anonymous (AA) to tobacco addiction. This may include
admitting you are powerless over your addiction to nicotine and having
a sponsor to talk with when you are tempted to use tobacco. These
meetings are free, though most will take donations.
Often your local American Cancer Society or local health
department
will sponsor quitting classes, too. Call us for more information.
There are also some programs to watch out for. Not all
programs are ethical. Think twice about any programs that:
- promise instant, easy success with no effort on your part
- use shots (injections) or pills, especially with secret
ingredients
- charge a very high fee -- check with the Better Business
Bureau if you have doubts
- are not willing to give you references from people who have
used the program
A word about success rates
Before you sign up for a tobacco cessation class or program,
you may
wonder what its success rate is. Success rates are hard to figure out
for many reasons. First, not all programs define success in the same
way. Does success mean that a person is not using tobacco at the end of
the program? After 3 months? Six months? One year? If a program you're
considering claims a certain success rate, ask for more details on how
success is defined and what kind of follow-up is done to confirm the
rate.
The truth is that programs to help you quit tobacco may give
you
more of an edge up than trying to quit on your own. But like other
programs that treat addictions, they often have a fairly low overall
success rate. This does not mean they are not worthwhile, or that you
should be discouraged. Your own success in quitting is what really
counts, and that is under your
control.
What about medicines to help you quit?
Tobacco addiction is mental and physical. Physical addiction
can
cause you to have withdrawal symptoms if you try to quit. For many
people this is a hard part of addiction to overcome.
Nicotine replacement therapy
Nicotine replacements (nicotine substitutes) give you nicotine
without the other harmful chemicals in tobacco. For cigarette smokers,
nicotine replacement therapy (NRT) has been proven to help reduce
withdrawal symptoms. Together with counseling or other support, it
doubles the chances that a smoker will quit. Fewer studies have been
done on how much NRT helps smokeless tobacco users quit. Since both
smokers and smokeless users are addicted to nicotine, some smokeless
tobacco users think it makes sense to try it.
The Food and Drug Administration (FDA) has approved these NRT
products as effective aids for helping people to quit smoking:
- nicotine gum
- nicotine patch
- nicotine lozenges
- nicotine inhaler
- nicotine nasal spray
(For more information on these products, see the document, Guide to Quitting Smoking.)
None of these products has been FDA approved specifically to
help
people quit smokeless tobacco. This is because it has not been proven
how well they work to help quit smokeless tobacco. The results of some
small studies have been mixed, and larger studies are needed. Still,
NRT may be useful in helping you quit, or at least in helping reduce
your cravings.
Nicotine gum, patches, and lozenges can be bought over the
counter
(without a prescription). Nicotine nasal spray and nasal inhalers are
available only with a doctor's prescription.
For smokeless tobacco users, certain types of NRT may help
more than
others. If you look at the way the tobacco is used, nicotine gum and
lozenges are most like using smokeless tobacco. They also let you
control your dose to help keep nicotine cravings at bay. The nicotine
inhaler may not be as useful for smokeless tobacco users, as it is
designed to look and feel like a cigarette filter tip. The nicotine
patch gives a steady dose of nicotine, but may not help with strong
cravings. Still, the patch may be more useful for people who prefer
once-a-day convenience. A 2007 study compared higher-dose nicotine
patches with the usual NRT doses in heavy users of smokeless tobacco.
The researchers found that higher doses were more helpful in reducing
withdrawal symptoms.
No matter which type of NRT you choose, make sure to follow
the
package instructions and don't use any tobacco, including smokeless
tobacco, when using nicotine replacement. You may want to talk with
your doctor, dentist, or pharmacist before using any of these products.
Getting the most from nicotine replacement
Nicotine replacement therapy only deals with the physical part
of
withdrawal. These products work best when they are used with other
quitting aids such as group sessions or counseling. They may reduce
withdrawal symptoms so you can focus on coping with the mental and
emotional aspects of addiction.
If you choose to use it, NRT works best if it is started at
the
beginning of an attempt to quit. Often tobacco users first try to quit
on their own, and then decide to try NRT. You should not use NRT if you
plan to continue to use any tobacco product. The combined dose of
nicotine can be dangerous.
Tobacco users who are pregnant or have heart disease should
talk to a doctor before using over-the-counter nicotine replacement.
Prescription medicines
Bupropion:
Bupropion (Zyban®) is a prescription
anti-depressant
in an extended-release form that reduces symptoms of nicotine
withdrawal. It does not contain nicotine. This drug acts on chemicals
in the brain that are related to nicotine craving. Bupropion is FDA
approved as an aid in quitting smoking, but it is not clear if it is
useful for smokeless tobacco users. A 2007 study found that it helped
reduce cravings and weight gain in people who were trying to quit
smokeless tobacco. But in that clinical trial, the group taking
bupropion was no more successful at quitting than the group taking
placebo (sugar pills).
Bupropion works best in smokers if it is started 1 or 2 weeks
before
the quit date. The usual dosage is one or two 150 mg tablets per day.
Talk to a doctor to find out if this might be an option for you.
Bupropion can be used alone or with NRT. You should not take
it if
you have ever had seizures, serious head injury, bipolar
(manic-depressive) illness, anorexia or bulimia (eating disorders), or
problems with heavy alcohol use.
Varenicline:
Varenicline (Chantix™) is a
prescription medicine
taken as a pill twice a day. It works by interfering with nicotine
receptors in the brain. It lessens the physical pleasure of taking in
nicotine and helps lessen the symptoms of nicotine withdrawal. Studies
have shown it works as least as well as bupropion (if not more so) in
helping people quit smoking, at least in the short term. Its effects in
quitting smokeless tobacco have not been studied.
Non-drug products and methods people may use
to quit
Other tobacco-related and nicotine-containing products have
appeared
in the past few years. Because they are not marketed to treat nicotine
addiction, the FDA doesn't consider them drugs and doesn't regulate
them. Some may be helpful, but none of these products has been proven
to work to help people quit using tobacco.
Non-tobacco snuff products
These are sold in grocery and convenience stores or by mail
order.
They are packaged like moist snuff in a tin and come in different
flavors. They are made from plants or herbs such as tea, clover, mint
leaves, kudzu, or alfalfa. Some have added flavors and moisteners like
glycerin. At least one contains an herb called guarana, which has quite
a bit of caffeine in it.
Non-tobacco snuffs can be used alone or mixed with regular
snuff as
a person is trying to cut down on tobacco. They are generally
considered safe as long as you are not allergic to anything in them,
but they have not been reviewed by the FDA. One study that used mint
snuff as a substitute found that it helped reduce cravings in smokeless
tobacco users who were trying to quit. But those who used the mint
snuff were no more likely to quit tobacco than those who didn't. If you
choose to try a non-tobacco snuff, check the ingredient list to see
what you are getting.
Tobacco lozenges and pouches
Lozenges that contain tobacco (like Ariva®
and
Stonewall®)
and small pouches of tobacco (like Revel®
and Exalt®)
are now
being marketed as other ways for smokers to get nicotine in places
where smoking is not allowed. They are not sold as ways to quit
tobacco. The FDA has also ruled that these are types of smokeless
tobacco, not aids to quit smoking or wean off tobacco. This means the
FDA does not have authority over them. There is no reason to think
these products would have fewer health risks than more common forms of
smokeless tobacco.
Nicotine lollipops and lip balms
In the past, some pharmacies made a product called a nicotine
lollipop. These lollipops often contained a product called nicotine
salicylate with a sugar sweetener. Nicotine salicylate is not approved
for pharmacy use by the FDA. The FDA has warned pharmacies to stop
selling nicotine lollipops and lip balm, calling the products
"illegal." The FDA also said "the candy-like products present a risk of
accidental use by children."
Other smoking cessation products like these may not use
nicotine
salicylate, and may be legal. But all of them still pose a risk for
children and pets if they are not stored safely and disposed of where
children and pets cannot get them.
Nicotine water and nicotine wafers
Like lozenges and pouches, these products have been sold as
ways to
get nicotine in places where smoking is not allowed. They are not
marketed as aids to quitting smoking, but questions about their safety
and legality have been raised. Some of these formulas can be quite
dangerous if accidentally taken by children or pets, so they must be
stored carefully.
Other non-drug quitting aids
Other tools may also help some people, but there is no strong
proof that they can improve their chances of quitting.
Hypnosis
Hypnosis methods vary a great deal, which makes hypnosis hard
to
study as a way to quit tobacco. For the most part, reviews that looked
at studies of hypnosis to help people quit smoking have not supported
it as a quitting method that works. As a way to quit using smokeless
tobacco, hypnosis has been studied even less. Still, it might be useful
for some people. If you would like to try it, ask your doctor to
recommend a good hypnotherapist.
Acupuncture
This method has been used for quitting tobacco, but there is
little
evidence to show that it works. It involves putting small needles into
the skin, usually around the ears. (For more information on
acupuncture, see our document, Acupuncture.)
For a list of local
physician acupuncturists, visit the American Academy of Medical
Acupuncture online at www.medicalacupuncture.org,
or call 323-937-5514.
Laser therapy
Low-level laser therapy is a related technique, which also has
very
little evidence to show that it works (see our document, Cold Laser
Therapy).
Tobacco deterrents
These include over-the-counter products that change the taste
of
tobacco, "quitting diets" that are supposed to curb nicotine cravings,
and combinations of vitamins. There is little scientific evidence to
support claims that any of these methods work.
Herbs and supplements
Because they are sold as dietary supplements (not drugs),
these
products don't need FDA approval. The manufacturers don't have to prove
they work, or even that they're safe. Be sure to look closely at the
label of any product that claims it can help you quit tobacco. Dietary
supplements and homeopathic remedies have no proven track record of
helping people quit tobacco (see our document, Homeopathy).
How
to quit
Tobacco users often say, "Don't tell me why to quit, tell me
how."
There is no one right way to quit, but there are some key elements in
quitting for good. The 4 key factors are:
- making the decision to quit
- setting a quit date and choosing a quit plan
- dealing with withdrawal
- staying quit (maintenance)
Deciding to quit
Only you can make the decision to quit using tobacco. Others
may want you to quit, but the real commitment must come from you.
Think about why you want to quit.
- Are you worried that you could get a
tobacco-related disease?
- Do you really believe that the benefits of quitting
outweigh the benefits of continuing to use tobacco?
- Do you know someone who has had health problems
because of tobacco use?
- Are you ready to make a serious try at quitting?
List your reasons for quitting
Tobacco users have many reasons for wanting to quit. But what
motivates you to quit may not be the same as what motivates others.
Think about making a list of the reasons you want to quit -- one you
can refer to later if you're feeling tempted. The list might include
some or all of the following, but be sure to add your own reasons:
- I want to be healthier.
- I already have problems with my gums/teeth, and I
don't want them to get worse.
- I don't want to spend my money on this.
- I can't chew/dip at work/school.
- I want to be able to go to a movie/mall/ballgame
without worrying about it.
- I want to prove I can do it.
- I don't want it to control me.
- The people I care about don't like it, and want me
to quit.
- I want to set a good example for the kids.
If you are thinking about quitting, setting a date and
deciding on a plan will move you to the next step.
Setting a quit date and making a plan
Once you've decided to quit, you're ready to pick a quit date.
This
is a very important step. Pick a day in the next month as your Quit
Day. Picking a date too far away gives you time to rationalize and
change your mind. But do give yourself enough time to prepare and come
up with a plan. You might choose a date that has a special meaning,
like a birthday or anniversary, or the date of the American Cancer
Society Great American Smokeout (the third Thursday in November each
year). Or you may want to just pick a random date. Circle the date on
your calendar. Make a strong, personal commitment to quit on that day.
There is no one right way to quit. Some tobacco users prefer
to quit
cold turkey. They use tobacco until their Quit Day and then stop
completely, all at once. Others may cut down on tobacco for a week or 2
before their Quit Day. There is more than one way to do this.
Cutting down on how much you use
One way to do this is to cut down on the number of times or
the
amount you dip or chew each day. By doing this, you slowly reduce the
amount of nicotine in your body. Try cutting back to half of your usual
amount before you quit. If you usually carry your tin or pouch with
you, try leaving it behind. Carry something else to put in your mouth
instead.
Cutting back on when and where you use
You can also try cutting back on when and where you dip or
chew.
This gives you a chance to notice when your cravings are the worst. It
helps you decide on a game plan if you know what triggers your
cravings. Again, once you've decided not to use tobacco at a certain
place, leave your pouch or tin at home when you go there. Try your
substitutes instead (See the section "Some steps
to help you prepare
for your Quit Day").
Putting off using tobacco when you have a
craving
Go as long as you can without giving into a craving. Start by
trying
for at least 10 minutes, then longer and longer as you near your Quit
Day. Pick your 3 worst triggers and stop dipping or chewing at those
times. This will be hard at first, but practice will make it easier.
Quitting tobacco is a lot like losing weight. It takes a
strong
commitment over a long time. Users may wish there were a magic bullet
-- a pill or method that would make quitting painless and easy. But
there is nothing like that. Nicotine substitutes can help reduce
withdrawal symptoms, but they work best when used as part of a quitting
plan that addresses the physical, mental, and emotional parts of
quitting.
Some
steps to help you prepare for your
Quit Day
- Pick the date and mark it on your calendar.
- Tell friends, family, and co-workers about your
Quit Day, and let them know how they can help.
- Get rid of all the tobacco in your home, car, and
place of work the night before your Quit Day.
- Stock up on other things to put in your mouth --
sunflower
seeds, sugarless gum, carrot sticks, beef jerky, cinnamon sticks,
and/or sugarless hard candy.
- Decide on a plan. Will you use nicotine replacement
therapy?
Will you go to a class or program? If so, sign up now. Find out where
and when they meet, so that you are ready.
- Consider seeing your doctor or dentist. Have them
check your mouth, and discuss your plan for quitting with them.
- Set up a support system. This could be a group
class,
Nicotine Anonymous, or friends or family members who have quit and are
willing to help you. Ask family and friends who use tobacco not to use
it around you or leave it out where you can see it.
- Make a list of your "triggers" -- situations,
places, or
feelings that make you more likely to chew or dip. Being aware of these
can help you avoid them or at least be ready for them.
- Think back to your past attempts to quit. Try to
figure out what worked and what did not work for you.
Quitting and staying quit is a matter of planning and
commitment,
not luck. Decide now on your own plan. Some options include joining a
tobacco cessation class, calling a cessation support line, going to
Nicotine Anonymous meetings, using nicotine replacement, online
support, and using self-help materials such as books and pamphlets. For
the best chance of success, your plan should include 2 or more of these
options.
On your Quit Day, follow these suggestions:
- Don't use tobacco of any kind. This means none, not
even a pinch!
- Keep active -- try walking, exercising, or doing
other activities or hobbies.
- Keep substitutes handy to put in your mouth.
- Drink lots of water and juices.
- Begin using nicotine replacement if that is your
choice.
- Call a quit support line, go to a quit class, or
start following your self-help plan.
- Avoid situations where the urge to dip or chew is
strong.
- Avoid alcohol. It can weaken your resolve to quit
- Think about changing your routine. Sit in a
different chair
at home, drive a new way to work, or choose foods and drinks that make
tobacco taste bad.
Read on to find out more about the kinds of thoughts and
temptations
that come up when you try to quit, and ideas for ways to deal with or
avoid them.
Dealing with withdrawal
Withdrawal from nicotine has 2 parts:
- physical withdrawal
- psychological or mental withdrawal
The physical withdrawal symptoms, while annoying, are not life
threatening. If you choose to use nicotine replacement, it can help
reduce many of these physical symptoms. Most users find that the bigger
challenge is the mental and emotional part of quitting.
If you have been using tobacco for any length of time, it
probably
has become linked with many of your activities -- watching TV; going to
sporting events; fishing, camping, or hunting; or driving your car. It
will take time to "un-link" tobacco use from these activities. That's
why, even if you are using the patch or gum, you may still have strong
urges to use tobacco.
Rationalizations are sneaky
One way to deal with these urges or cravings is to recognize
rationalizations as they come up. A rationalization is a mistaken
thought that seems to make sense to you at the time, but is not based
on reality. If you choose to believe such a thought, it can serve as a
way to justify using tobacco. If you have tried to quit before, you'll
probably recognize some of these common rationalizations:
- I'll just use it to get through this rough spot.
- Today is not a good day; I'll quit tomorrow.
- It's my only vice.
- How bad is tobacco, really? Uncle Harry chewed all
his life and he lived to be over 90.
- You've got to die of something.
- Life is no fun without chewing (or dipping).
You probably can add more to the list. As you go through the
first
few days without tobacco, write down any rationalizations as they come
up and recognize them for what they are: messages that can trick you
into going back to using tobacco. Look out for them, because they
always show up when you're trying to quit. After you write down the
idea, let it go from your mind. Be ready with a distraction, a plan of
action, and other ways to re-direct your thoughts to something else.
Use the ideas below to help keep you stay committed to
quitting.
Avoid
temptation: Stay away from people and places where you
are
tempted to use tobacco. Later on you will be able to handle these with
more confidence.
Change your
habits: Switch to juices or water instead of
alcohol or
coffee. Take a different route to work. Take a brisk walk instead of a
chew. Here are some more ideas:
Alternatives. Use
oral substitutes like sunflower seeds, beef
jerky,
sugarless gum or hard candy, or raw vegetables such as carrot sticks.
Take a sip or a bite of something that makes tobacco taste bad. You may
want to try mint (non-tobacco) snuff or another herbal version if you
need help with cravings.
Activities. Exercise
or do hobbies that keep your hands busy
(such
as woodworking, puzzles, gardening) and require enough brain focus to
distract you from the urge to use.
Deep breathing. When
the urge to use strikes, relax, breathe
deeply,
and picture your lungs filling with fresh, clean air. Remind yourself
of why you are quitting and the benefits you'll gain.
Delay. If you feel
that you are on the verge of giving in,
delay.
Tell yourself you must wait at least 10 minutes. Often this simple
trick will allow you to move beyond the strong urge to use tobacco.
Reward yourself:
What you're doing is not easy and you deserve
a
reward. Put the money you would have spent on tobacco in a jar every
day and then buy yourself a weekly treat. Buy a magazine or some new
music, go out to eat, call a friend long-distance. Or save the money
for a major purchase. You can also reward yourself in ways that don't
cost money: take time out to read, work on a hobby, or take a relaxing
bath.
Enjoy the new
you: Make an appointment with your dentist to
get your
teeth cleaned and whitened. Take your spouse or partner out on a date,
even if you've been together for years. If you're not in a
relationship, start talking to someone you'd like to know better. You
won't have to worry about your tobacco-breath or brown teeth!
Staying quit (maintenance)
Staying quit is the final, longest, and most important stage
of the
process. You can use the same methods to stay quit as you did to help
you through withdrawal. Plan ahead for those times when you may be
tempted to use tobacco. Think about other ways to cope with these
situations.
More dangerous, perhaps, are the unexpected strong desires to
use
tobacco that crop up months or even years after you've quit. To get
through these without relapse, try the following:
- Review your reasons for quitting -- look at your
list and
think of all the benefits to your health, your finances, and your
family.
- Remind yourself that there is no such thing as just
one chew or dip.
- Ride out the desire. It will go away, but do not
fool yourself into thinking you can have just one dip or chew.
- Avoid drinking alcohol. It lowers your chance of
success.
What if you slip and use tobacco after your
Quit Day?
The difference between a slip and a relapse is within your
control.
A slip is a one-time mistake that is quickly corrected. A relapse is
going back to your former habit. You can use the slip as an excuse to
go back to using tobacco, or you can look at what went wrong and renew
your commitment to staying away from tobacco for good.
Even if you do relapse, try not to get too discouraged. Many
people
are not able to quit for good on the first attempt. In fact, it takes
most people many attempts before quitting for good. What's important is
figuring out what helped you in your attempt to quit and what worked
against you. You can then use this information to make a stronger
attempt at quitting the next time. Learn from your mistakes -- don't
give up!
Some other concerns
Weight gain
Although it is well known that smokers often gain weight when
they
quit, fewer studies have been done on quitting smokeless tobacco.
Researchers in a small 2007 study looked at people who were trying to
quit smokeless tobacco. They gave bupropion to one group, and sugar
pills (placebo) to the other. Even though there was no significant
difference in quit rates between the groups in the study, there was a
difference in weight gain among the people who were able to quit. The
researchers found that quitters who took the drug gained an average of
about 4 pounds, while those in the control group gained about 7 pounds.
These findings suggest that people who quit smokeless tobacco have some
risk of weight gain.
You are more likely to succeed in quitting if you deal with
quitting
tobacco first, and then later take steps to reduce your weight. While
you are quitting, try to focus on ways to help you stay healthy, rather
than on your weight. Stressing about your weight may make it harder to
quit. Eat plenty of fruits and vegetables and limit the fat. Be sure to
drink lots of water, and get enough sleep and regular physical
activity.
Try walking
Walking is a great way to be physically active and increase
your chances of staying quit. Walking can help you by:
- reducing stress
- burning calories and toning muscles
- giving you something to do instead of thinking
about tobacco
You don't need special equipment or clothing for walking,
other than
a pair of comfortable shoes. And you can do it pretty much anytime. Try
the following:
- Walk around a shopping mall.
- Get off the bus one stop before you usually do.
- Find a buddy to walk with during lunch time at
work.
- Take the stairs instead of the elevator.
- Walk with a friend, family member, or neighbor
after dinner.
- Push your baby in a stroller, walk your dog, or
offer to walk someone else's dog.
Set a goal of 30 minutes of physical activity 5 or more times
a
week. If you don't already exercise regularly, please check with your
doctor before starting any exercise program.
Stress
Tobacco users often mention stress as one of the reasons for
going
back to using tobacco. Stress is a part of everyone's life. The
difference is that tobacco users have come to use nicotine to help cope
with stress and unpleasant emotions. When quitting, you have to learn
new ways to handle stress. This can be tough, especially during the
first few days. It's important to let those around you know what you're
going through and ask for their understanding. Nicotine replacement can
help to some extent, but for long-term success other strategies are
needed.
As mentioned before, physical activity is a good stress
reducer. It
can also help with the short-term sense of depression that some tobacco
users have when they quit.
Stress-management classes and self-help books may also be
helpful. Check your community newspaper, library, or bookstore.
Spiritual practices such as admitting that you can't control
your
addiction and believing that a higher power can give you strength have
been used with much success to deal with other addictions. These
practices, along with the fellowship of others on a similar path, are a
key part of 12-step recovery programs. These same principles can be
applied to quitting tobacco. Nicotine Anonymous uses these 12 steps
(see the "National
organizations and Web sites"
section). You may also want to use other spiritual practices like
prayer and meditation, especially if they have helped you through tough
times in the past.
Taking care of yourself
It is important for your health care provider to know of any
present
or past tobacco use so he or she can be sure that you will get the
preventive health care you need. It is well known that using tobacco
use puts you at risk for certain health-related illnesses, so part of
your health care should focus on related screening and preventive
measures to help you stay as healthy as possible. For example, make
sure you regularly check inside your mouth for any changes. Have your
doctor or dentist look at your mouth, tongue, or throat if you have any
changes or problems. The American Cancer Society recommends that
medical check-ups should include oral cavity (mouth) exams. This way,
tobacco users may be able to find changes such as leukoplakia (white
patches on the mouth tissues) early, and prevent oral cancer or find it
at a stage that is easier to treat.
If you think you have any health concerns that may be related
to
your tobacco use, please see a health care provider as soon as
possible. Taking care of yourself and getting treatment for small
problems will give you the best chance for successful treatment. The
best way, though, to take care of yourself and decrease your risk for
life-threatening health problems is to quit using tobacco.
Where can I go for help?
It's hard to give up tobacco. But if you are a tobacco user
you can
quit! Many organizations offer information, counseling, and other
services focusing on how to quit and where to go for help. Other good
resources to ask for help can include your doctor, dentist, local
hospital, or employer. You can call us at 1-800-227-2345 or visit us
online at www.cancer.org.
There are also other groups listed below that
can help you.
Additional resources
More information from your American Cancer
Society
We have selected some related information that may also be
helpful
for you. These materials may be viewed on our Web site or ordered from
our toll-free number.
National
organizations and Web sites*
If you want to quit smoking and need help, contact one of the
following organizations. Along with the American Cancer Society, other
sources of information and support include:
Centers for
Disease Control and Prevention
Office on Smoking and
Health
Toll-free number: 1-800-232-4636 (1-800-CDC-INFO)
Web site: www.cdc.gov/tobacco/
Free quit support line: 1-800-784-8669 (1-800-QUIT-NOW)
TTY: 1-800-332-8615
Kill the Can
Web site: www.killthecan.org
Online information and support for those committed to quitting
smokeless tobacco
National Cancer
Institute
Toll-free number: 1-800-422-6237 (1-800-4-CANCER)
Web site: www.cancer.gov
Toll-free tobacco line: 1-877-448-7848
Tobacco quit line: 1-800-784-8669 (1-800-QUITNOW)
Direct tobacco Web site: www.smokefree.gov
Quitting information, cessation guide, and counseling is offered, as
well as information on state telephone-based quit programs
Nicotine
Anonymous
Toll-free number: 1-877-879-6422
Web site: www.nicotine-anonymous.org
For free information, meeting schedules, printed materials, or
information on how to start a group in your area
*Inclusion on
this list does not imply endorsement by the
American Cancer Society.
No matter who you are, we can help. Contact us anytime, day or
night, for information and support. Call us at 1-800-227-2345 or visit
www.cancer.org.
References
American Cancer Society. Cancer
Facts & Figures 2009.
Atlanta, Ga. 2009.
Benowitz NL. Pharmacology of Smokeless Tobacco Use: Nicotine
Addiction and Nicotine-Related Health Consequences. In: Smokeless
Tobacco or Health: An International Perspective. Smoking
and Tobacco
Control Monograph No.2. Bethesda (MD): U.S. Department of Health and
Human Services, Public Health Service, National Institutes of Health.
NIH Publication No. 93-3461, 1992b:219-228. Accessed at:
http://cancercontrol.cancer.gov/tcrb/monographs/2/m2_4.pdf on September
29, 2009.
Benowitz NL. Pharmacologic aspects of cigarette smoking and
nicotine addiction. N
Engl J Med. 1988;319:1318–1330.
Benowitz NL, Jacob P III, Yu L. Daily use of smokeless
tobacco: Systemic effects. Ann
Intern Med. 1989;111:112–116.
Boffetta P, Hecht S, Gray N, et al. Smokeless tobacco and
cancer. Lancet Oncol.
2008;9(7):667–675.
Boffetta P, Straif K. Use of smokeless tobacco and risk of
myocardial infarction and stroke: systematic review with meta-analysis.
BMJ.
2009;339.
Campaign for Tobacco-Free Kids. Smokeless Tobacco and Kids.
July
2008. Accessed at:
http://tobaccofreekids.org/research/factsheets/pdf/0003.pdf on
September 23, 2009.
Centers for Disease Control and Prevention (CDC). Smoking and
Tobacco Use: National Youth Tobacco Survey, 2006 NYTS Data and
Documentation. Accessed at:
www.cdc.gov/tobacco/data_statistics/surveys/NYTS/#NYTS2006 on September
29, 2009..
Centers for Disease Control and Prevention (CDC). Tobacco use,
access, and exposure to tobacco in media among middle and high school
students --- United States, 2004. MMWR. 2005;54;297–301.
Accessed
at: www.cdc.gov/mmwr/preview/mmwrhtml/mm5412a1.htm on September 29,
2009.
Centers for Disease Control and Prevention (CDC). Youth Risk
Behavior Surveillance --- United States, 2007. MMWR.
2008;57(SS-04);1-31. Accessed at:
www.cdc.gov/mmwr/preview/mmwrhtml/ss5704a1.htm on September 23, 2009.
Centers for Disease Control and Prevention (CDC). Smokeless
Tobacco.
Accessed at:
www.cdc.gov/tobacco/data_statistics/fact_sheets/smokeless/smokeless_facts/index.htm
on September 23, 2009.
Cogliano V, Straif K, Baan R, et al. Smokeless tobacco and
tobacco-related nitrosamines. Lancet
Oncol. 2004;5:708.
Critchley JA, Unal B. Is smokeless tobacco a risk factor for
coronary heart disease? A systematic review of epidemiological studies.
Eur J Cardiovasc Prev
Rehabil. 2004;11:101–1012.
Dale LC, Ebbert JO, Glover ED, et al. Bupropion SR for the
treatment
of smokeless tobacco use. Drug
Alcohol Depend. 2007;90:56–63.
Ebbert JO, Dale LC, Patten CA, et al. Effect of high-dose
nicotine
patch therapy on tobacco withdrawal symptoms among smokeless tobacco
users. Nicotine Tob Res.
2007;9:43–52.
Ebbert J, Montori V, Vickers K, et al. Interventions for
smokeless tobacco use cessation.
Cochrane Database Syst
Rev. 2007;(4):CD004306.
Fiore MC, Jaén CR, Baker TB, Bailey WC, Benowitz
NL, Curry
SJ. et al, for the Guideline Panel. Treating Tobacco Use and
Dependence: 2008 Update. In National Library of Medicine (NLM).
Treating Tobacco Use and
Dependence: 2008 Update. Accessed at:
www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat2.section.28165 on
September 29, 2009.
Govtrack.us. 111th Congress 2009-2010. H.R.1256: Family
Smoking
Prevention and Tobacco Control Act. Accessed at:
www.govtrack.us/congress/bill.xpd?bill=h111-1256 on September 23, 2009.
Hatsukami DK, Grillo M, Boyle R, et al. Treatment of spit
tobacco
users with transdermal nicotine system and mint snuff. J Consult Clin
Psychol. 2000;68(2):241–249.
Hatsukami KD, Gust SW, Keenan RM. Physiologic and subjective
changes
from smokeless tobacco withdrawal. Clin
Pharmacol and Ther.
1987;41:103–107.
Hatsukami DK, Lemmonds C, Zhang Y, et al. Evaluation of
carcinogen
exposure in people who used "reduced exposure" tobacco products. J Natl
Cancer Inst. 2004;96:844–852.
Henley SJ, Connell CJ, Richter P, et al. Tobacco-related
disease
mortality among men who switched from cigarettes to spit tobacco.
Tobacco Control.
2007;16:22–28.
Henley SJ, Thun MJ, Connell C, Calle EE. Two large prospective
studies of mortality among men who use snuff or chewing tobacco (United
States). Cancer Causes
Control. 2005;16:347–358.
Holm H, Jarvis MJ, Russwell MAH, Feyerabend C. Nicotine intake
and
dependence in Swedish snuff takers. Psychopharmacology.
1992;108:507–511.
IARC Working Group on the Evaluation of Carcinogenic Risks to
Humans. Smokeless Tobacco and Some Tobacco-specific N-Nitrosamines.
Volume 89. World Health Organization International Agency For Research
On Cancer. 2007. Accessed at:
http://monographs.iarc.fr/ENG/Monographs/vol89/mono89.pdf on September
23, 2009.
Keller PA, Beyer EJ, Baker TB, et al. Tobacco Cessation
Quitline
Spending in 2005 and 2006: What State-Level Factors Matter? Int. J.
Environ. Res. Public Health. 2009;6:259–266.
National Institute of Dental and Craniofacial Research. Spit
Tobacco: A Guide For Quitting. September 2006. Accessed
at:
www.nidcr.nih.gov/NR/rdonlyres/DF314871-B0A6-4171-B831-C472F543C154/0/SpitTobacco.pdf
on September 29, 2009.
Office of the U.S. Surgeon General. 1998 Surgeon General's
Report
– Tobacco Use Among U.S. Racial/Ethnic Minority Groups.
Centers
for Disease Control and Prevention (CDC), Office on Smoking and Health.
1998. Accessed at:
www.cdc.gov/tobacco/data_statistics/sgr/sgr_1998/index.htm on September
29, 2009.
Office of the U.S. Surgeon General. The Health Consequences of
Using
Smokeless Tobacco: A Report of the Surgeon General.
Centers for Disease
Control and Prevention (CDC), Office on Smoking and Health. 1986.
Accessed at: http://profiles.nlm.nih.gov/NN/B/B/F/C/ on September 29,
2009.
Severson HH. Enough
Snuff: A Guide for Quitting on Your Own.
6th ed. Eugene, Oregon: Applied Behavior Science Press. 2002.
Severson HH, Klein K, Lichtenstein E, et al. Smokeless tobacco
use
among professional baseball players: Survey results, 1998 to 2003.
Tobacco Control.
2005;14:31–36.
Substance Abuse and Mental Health Services Administration.
Office of
Applied Studies. Results
from the 2005 National Survey on Drug Use and
Health: Detailed Tables. Accessed at:
http://oas.samhsa.gov/NSDUH/2k5nsduh/tabs/Sect2peTabs37to41.pdf on
September 29, 2009.
The S.T.O.P. Guide: Smokeless Tobacco Cessation. Applied
Behavioral Science Press. 2002.
U.S. Department of Health and Human Services. Results from the
2007
National Survey on Drug Use and Health: Detailed Tables.
SAMHSA, Office
of Applied Studies. Accessed at:
www.oas.samhsa.gov/NSDUH/2k7NSDUH/tabs/TOC.htm on September 23, 2009.
U.S. Department of Health and Human Services. The Health
Consequences of Involuntary Smoking: A Report of the Surgeon General.
Washington, DC: Department of Health and Human Services; 1986. Report
No.: Publication No (PHS) 87-839.
Zendehdel K, Nyrén O, Luo J, et al. Risk of
gastroesophageal
cancer among smokers and users of Scandinavian moist snuff. Int J
Cancer. 2008;122(5):1095–1099.
Last Medical Review: 10/14/2009
Last Revised: 10/14/2009
|