Liver cancer usually does not cause symptoms until it is in its later stages, so it is seldom found early. Also, there are no screening tests for liver cancer, and small tumors are hard to find by physical exams.

Tests that may be done to find liver cancer

Many patients who develop liver cancer have had cirrhosis for a long time. If a patient with cirrhosis gets worse for no known reason, doctors should suspect that liver cancer may be the cause and do the tests needed to find out if this is the case.

AFP test

Liver cancers can sometimes be found using a blood test for a protein called AFP (alpha-fetoprotein). It is normal for AFP to be found in the blood of unborn babies, but it disappears shortly after birth. If it is found in the blood of adults they may have a liver cancer (or another kind of cancer).

Tests for AFP have been used to look for early tumors in people at high risk for liver cancer. Some tumors, though, do not produce much of this protein. So by the time the AFP is high enough to be found, the tumor may be too large to be removed or may have spread outside the liver. Some non-cancerous liver diseases can also raise AFP levels.

Ultrasound

Ultrasound is a test that uses sound waves to make pictures of internal organs such as the liver. For an ultrasound, you lie on a table while a wand is moved over the part of the body being looked at. Ultrasound is sometimes used in people with certain liver cancer risk factors to help find cancers earlier. It may also be done before a biopsy to see if the tumor is a fluid-filled cyst (most likely benign) or a solid tumor.

Who should be tested?

People at higher risk for liver cancer may be helped by screening, that is, they are tested before they have symptoms. Many doctors recommend testing for certain groups. These include people with cirrhosis, especially if it is so bad that the patient is waiting to get a liver transplant. Otherwise a cancer may start during the wait and become so advanced that it can't be cured. Having liver cancer will also move the person up on the transplant waiting list.

Some people with chronic HBV or HCV infections should also be screened, such as those with liver cancer in the family. For other people at higher risk, the benefits of screening may not be as clear. If you think you are at high risk for liver cancer, talk to your doctor about whether screening is a good option for you.

Symptoms of liver cancer

Most of the time liver cancer does not cause symptoms in the early stages. The symptoms below could be caused by liver cancer. But they can also be caused by other cancers or conditions. Still, if you have any of the following problems, see a doctor right away.

• weight loss (when you're not trying to lose weight)
• on-going lack of appetite
• nausea or vomiting
• fever
• feeling very full after a small meal
• an enlarged liver or a mass that can be felt on the right side
• an enlarged spleen, felt as a mass under the ribs on the left side
• ongoing stomach pain
• swelling in the area of your stomach
• itching
• yellowing of the skin and eyes (jaundice)
• swollen veins on the belly that can be seen through the skin
• becoming sicker if you have chronic hepatitis or cirrhosis

Some liver tumors make hormones that act on organs other than the liver. These hormones may cause:

• high blood calcium levels which can cause nausea, confusion, constipation, weakness, or muscle problems

• low blood sugar levels, which can make you feel very tired or faint

• breast enlargement and/or shrinking of the testicles in men

These findings may cause doctors to suspect a disease of the nervous system or an endocrine (hormone-producing) gland, rather than a liver cancer. Tests will be needed.

Tests to get a better look at liver cancer

If you have any symptoms or if there is any reason to suspect liver cancer, your doctor will use one or more tests to find out if you really have the disease. You will have a physical exam and your doctor will ask you questions about your health. Some of the tests that may be done are listed below.

Imaging tests

These tests use x-rays, magnetic fields, or sound waves to create pictures of the inside of your body. The tests may be done for a number of reasons, such as to help find tumors that might be cancer, to learn how far cancer may have spread, and to help find out if treatment is working.

Ultrasound: This test is used to find tumors in the liver. Sound waves are used to produce a picture of the inside of the body. Most people know about ultrasound because it is often used to look at a baby during pregnancy. Different echo patterns can help tell if there is a tumor and, in some cases, what type it is.

This is an easy test to take. You simply lie on a table and a kind of wand is moved over the part of the body being looked at.

CT Scans (computed tomography): A CT scan uses x-rays to take many pictures of the body. The pictures are then put together to show images of slices of the part of your body being studied. CT scans can give precise information about the size, shape, and place of any tumors in the liver or other places in the belly (abdomen).

During the test you will most likely get an injection of a dye that helps outline the organs inside. You must lie still for 15 to 30 minutes while the pictures are taken, but CT scans are getting faster all the time.

MRI (magnetic resonance imaging): MRI scans use radio waves and strong magnets instead of x-rays to take pictures. A computer makes the pattern of radio waves into a detailed picture of parts of the body. MRI scans are very helpful in looking at liver cancers. Sometimes they can tell a benign tumor from a cancerous one. MRI scans take longer than CT scans and you may be inside a large tube-like machine. But some areas now have newer, more open machines.

Angiography: Angiography is an x-ray method used to look at blood vessels. A dye is injected into an artery before the x-rays are taken. The dye outlines the blood vessels on the pictures, showing which ones take blood to the liver cancer. This can help surgeons decide whether the cancer can be removed and, if so, how best to plan the operation.

This test can be uncomfortable because a tiny tube (catheter) has to be threaded from the groin up into the liver artery. Usually drugs are used to make the area numb before this is done (local anesthetic).

Laparoscopy: In a laparoscopy the doctor uses a thin, lighted tube to look at the liver and other organs. The tube is put in through a small cut (incision) in the front of the belly (abdomen). This can help the doctor in planning surgery or other treatments. Also, doctors can use small instruments through this tube to take out tissue samples to be looked at under the microscope (called a biopsy). You will be given drugs to make you sleepy during this test.

Biopsy

Other tests can suggest that a liver cancer is present, but in most cases the only way to be sure is to take a piece of the tumor and look at it under a microscope. This is called a biopsy. There are different ways to get the tumor sample. When a biopsy is done, the skin where the needle is placed is first numbed. Biopsy samples can also be taken during laparoscopy, when the doctor looks at the surface of the liver and takes samples from areas that look abnormal.

Blood tests

Blood tests can be done to check for a substance called AFP (alpha-fetoprotein). AFP levels are often high in people with liver cancer. Doctors can compare the AFP levels before and after treatment to see how well the treatment is working. Other blood tests can also help the doctor learn how well the part of your liver that is not affected by cancer is doing, and how well your other organs are working. This information can help doctors decide whether surgery is an option for you.

Last Medical Review: 01/09/2009
Last Revised: 05/06/2009