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Molecular pathology of endometrial cancer
Recent research has improved our understanding of how changes
in certain molecules can cause normal endometrial cells to become
cancerous. It has been known for several years that damaged or
defective DNA (called mutations) can alter important genes that
regulate cell growth. If these genes are damaged, out-of-control growth
may result in cancer.
Sometimes, endometrial cancer and colon cancer may seem to
"run in a family." We now know that some of these families have a
higher risk for these cancers because they have an inherited defect in
certain genes that normally help repair damage to DNA. If these repair
enzymes are not working properly, damage to DNA is more likely to
persist and cause cancer, Similar DNA repair defects have also been
found in endometrial cancer cells from some patients without an
inherited tendency to develop this disease. One of the normal genes
responsible for suppressing tumor growth, called PTEN, is often
abnormal in endometrial cancers.
Tests for this and other DNA changes may someday help find
endometrial cancers early. Endometrial cancers without other tumor
suppressor genes (or with inactive ones), such as the retinoblastoma
(Rb) gene and the p53 gene, tend to be more likely to come back after
initial treatment. Tests for these and other DNA changes may someday be
used to help predict how aggressive the cancer might be and to select
the best treatment for each woman with this disease. The long-range
goal of this field of research is gene therapy that can correct the DNA
abnormalities that caused the endometrial cells to become cancerous.
Tumor markers
Molecules released by cancer cells can help detect recurrence
of some types of cancer. For example, CA 125 is a useful marker in
finding recurrent ovarian cancer. Recent studies find that blood tests
for CA 125 may also be helpful in finding recurrent endometrial cancer,
before tumor deposits are visible by CT or MRI scans. Measuring CA 125
levels in some patients before surgery may also be helpful if it
appears the cancer may have spread. This may be useful in deciding
which patients will benefit from surgical staging and which patients
might be safely treated by hysterectomy without lymph node sampling.
New treatments
Researchers are examining new drugs, combinations of drugs and
"targeted therapies" in patients with advanced endometrial cancer. The
use of adjuvant chemotherapy, with or without radiation is also under
investigation.
Surgery
Another way to see if cancer has spread to the lymph nodes in
the pelvis is to identify and remove the lymph nodes that most likely
are draining the cancer. This is called sentinel lymph node biopsy. In
this procedure, radioactive tracer and/or blue dye is injected into the
area with the cancer. The lymph nodes that turn blue (from the dye) or
that become radioactive (from the tracer) are removed at surgery. These
lymph nodes are examined closely to see if they contain any cancer
cells. This technique is commonly used for some other tumors, such as
breast cancer, but it is still new in the treatment of endometrial
cancer. It is not known if sentinel lymph node biopsy is as good as
lymph node dissection for staging and treatment of endometrial cancer.
This is why it is not part of the standard surgery for this cancer.
Last Medical Review: 10/22/2009
Last Revised: 10/22/2009
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