The Extramural Grants department reviews and administers both Research Grants and Health Professional Training Grants (HPTGs). HPTGs include both grants and scholarships awarded to nurses, physicians, and oncology social work professionals. As the nation's largest private, not-for-profit source of funds for scientists studying cancer, the American Cancer Society (ACS) focuses its funding on investigator-initiated, peer-reviewed proposals. This process ensures that scientists propose projects that they believe are ready to be tackled with the available knowledge and techniques, rather than working on projects designed by administrators who are far removed from the front lines of research. This intellectual freedom encourages discovery in areas that scientists believe are most likely to solve the problems of cancer.

The Extramural Grants department is headed by William H. Chambers, PhD, National Vice President, Extramural Grants.