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microsatellite instability

[my-crow-SAT-uh-lite in-stuh-BILL-uh-tee] also called MSI. A type of genetic mutation often linked to hereditary non-polyposis colon cancer (HNPCC). This mutation causes size differences in sections of deoxyribonucleic acid (DNA) that are normally the same size in all cells. Testing for MSI is done on tissue taken from the cancer to find out if this DNA is of different lengths; if it is, HNPCC genetic testing is usually offered. See also deoxyribonucleic acid, genetic testing, hereditary non-polyposis colon cancer, mutation.

Saved this Article

... What does it mean if my biopsy report mentions special studies such as
microsatellite instability and MSH2, MSH6, MLH1, and PMS2? ...

http://www.cancer.org/treatment/understandingyourdiagnosis/understandingyourpathologyreport/colonpathology/invasive-adenocarcinoma-of-the-colon

Peter T. Campbell, PhD | American Cancer Society ...

Dr. Peter T. Campbell, PhD is the Director of the Tumor Repository for the
Epidemiology Research Program for the American Cancer Society. Learn ...

http://www.cancer.org/research/acsresearchers/peter-campbell-phd

References: Testicular cancer detailed guide

... Microsatellite instability, mismatch repair deficiency and BRAF mutation in
treatment resistant germ cell tumors. J Clin Oncol. 2009;27:2129-2136. ...

http://www.cancer.org/cancer/testicularcancer/detailedguide/testicular-cancer-references

Peter T Campbell

... (2010) Case-control study of obesity, overweight and colorectal cancer
risk, overall and by tumor microsatellite instability status. ...

http://www.cancer.org/research/researchprogramsfunding/epidemiology-cancerpreventionstudies/ourstaff/peter-t-campbell

What's new in colorectal cancer research and treatment?

... Chemo that does not include 5-FU for patients whose colorectal cancers
show microsatellite instability (MSI). People whose ...

http://www.cancer.org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-new-research

How is endometrial cancer diagnosed?

... tissue can be tested for protein changes (such as having fewer mismatch repair
proteins) or DNA changes (called microsatellite instability, or MSI ...

http://www.cancer.org/cancer/endometrialcancer/detailedguide/endometrial-uterine-cancer-diagnosis

How is colorectal cancer diagnosed?

... MSI testing: Sometimes the tumor tissue will be tested to see if it shows
changes called microsatellite instability (MSI). This ...

http://www.cancer.org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-diagnosed

Cancer Glossary

... under a microscope. microsatellite instability Search [my-crow-SAT-
uh-lite in-stuh-BILL-uh-tee]. also called MSI. A type of ...

http://www.cancer.org/cancer/cancerglossary/index.aspx?letter=m

Heredity and Cancer

... of these genes is faulty. These changes are known as microsatellite
instability (or MSI). Having normal findings (no MSI ...

http://www.cancer.org/cancer/cancercauses/geneticsandcancer/heredity-and-cancer

Other Publications

... Case-control study of overweight, obesity, and colorectal cancer risk, overall
and by tumor microsatellite instability status. J Natl Cancer Inst. ...

http://www.cancer.org/research/researchprogramsfunding/epidemiology-cancerpreventionstudies/publications/other-publications