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mutation

[mew-tay-shun] a change in the deoxyribonucleic acid (DNA) of a cell. Most mutations do not cause cancer, and a few may even be helpful. But all types of cancer are thought to be due to mutations that damage a cell’s DNA. Some cancer-related mutations can be inherited (passed on from a parent). This means that the person is born with the mutated DNA in all the body’s cells. But most mutations happen after the person is born. These are called somatic or acquired mutations. This type of mutation happens in one cell at a time, and only affects cells that arise from the single mutated cell. See also cancer susceptibility genes, deoxyribonucleic acid, gene, inherited mutation, somatic mutation.

What are mutations?

... For a person who is not born with a mutation, 2 acquired mutations (one in
each copy of the same gene) are needed to knock out that gene. ...

http://www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations

Genes, mutations, and cancer risk | American Cancer Society

... » Genetics and Cancer » Genetic Testing: What You Need to Know » Genes,
mutations, and cancer risk. ... Genes, mutations, and cancer risk. ...

http://www.cancer.org/cancer/cancercauses/geneticsandcancer/genetictesting/genetic-testing-intro

Gene mutations that can lead to cancer

... Most cancer-causing mutations involving oncogenes are acquired, not ...
oncogenes by chromosome rearrangements, gene duplication, or mutation. ...

http://www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-mutations-and-cancer

Gene Mutation Linked to Hereditary Prostate Cancer

... The mutation was found in white families. Two other mutations on the
HOXB13 gene were found in African-American families. ...

http://www.cancer.org/cancer/news/news/gene-mutation-linked-to-hereditary-prostate-cancer

New finding may unlock secrets of BRCA mutations

... “Now that researchers can purify the protein, they can create a mutation in
the lab ... There are hundreds of different BRCA mutations, Phelps says. ...

http://www.cancer.org/cancer/news/news/finding-may-unlock-secrets-of-brca-mutations

Can breast cancer be prevented?

... a BRCA mutation recognize they also have a high risk of developing ovarian
cancer. Most doctors recommend that women with BRCA mutations ...

http://www.cancer.org/cancer/breastcancer/detailedguide/breast-cancer-prevention

Do we know what causes colorectal cancer?

... In many cases, the first mutation occurs in the APC gene. ... Further mutations
may then occur in genes such as KRAS, TP53, and SMAD4. ...

http://www.cancer.org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-what-causes

What are mutations?

... For a person who is not born with a mutation, 2 acquired mutations (one in
each copy of the same gene) are needed to knock out that gene. ...

http://www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations?ssdomainnum=5c38e88&ssdomainnum=5c38e88&url=http%3A//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%3Furl%3Dhttp%253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%253furl%253dhttp%25253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%25253furl%25253dhttp%2525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%2525253furl%2525253dhttp%252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%252525253furl%252525253dhttp%25252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%25252525253furl%25252525253dhttp%2525252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%2525252525253furl%2525252525253dhttp%252525252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%252525252525253furl%252525252525253dhttp%25252525252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%25252525252525253furl%25252525252525253dhttp%2525252525252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppress

What are mutations?

... For a person who is not born with a mutation, 2 acquired mutations (one in
each copy of the same gene) are needed to knock out that gene. ...

http://www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations?ssdomainnum=5c38e88&ssdomainnum=5c38e88&ssdomainnum=5c38e88&url=http%3A//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%3Furl%3Dhttp%253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%253furl%253dhttp%25253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%25253furl%25253dhttp%2525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%2525253furl%2525253dhttp%252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%252525253furl%252525253dhttp%25252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%25252525253furl%25252525253dhttp%2525252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%2525252525253furl%2525252525253dhttp%252525252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%252525252525253furl%252525252525253dhttp%25252525252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%25252525252525253furl%25252525252525253dhttp%2525252525252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/onco

What are mutations?

... For a person who is not born with a mutation, 2 acquired mutations (one in
each copy of the same gene) are needed to knock out that gene. ...

http://www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations?ssdomainnum=5c38e88&url=http%3A//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%3Furl%3Dhttp%253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%253furl%253dhttp%25253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%25253furl%25253dhttp%2525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%2525253furl%2525253dhttp%252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%252525253furl%252525253dhttp%25252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%25252525253furl%25252525253dhttp%2525252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%2525252525253furl%2525252525253dhttp%252525252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%252525252525253furl%252525252525253dhttp%25252525252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-what-are-mutations%25252525252525253furl%25252525252525253dhttp%2525252525252525253a//www.cancer.org/cancer/cancercauses/geneticsandcancer/oncogenesandtumorsuppressorgenes/oncogenes-tumor-suppressor-genes-and-cancer-