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mutation

[mew-tay-shun] a change in the deoxyribonucleic acid (DNA) of a cell. Most mutations do not cause cancer, and a few may even be helpful. But all types of cancer are thought to be due to mutations that damage a cell’s DNA. Some cancer-related mutations can be inherited (passed on from a parent). This means that the person is born with the mutated DNA in all the body’s cells. But most mutations happen after the person is born. These are called somatic or acquired mutations. This type of mutation happens in one cell at a time, and only affects cells that arise from the single mutated cell. See also cancer susceptibility genes, deoxyribonucleic acid, gene, inherited mutation, somatic mutation.

Researchers Learn More About a Rare Genetic Mutation ...

... mutations to the BRCA1 or BRCA2 genes. According to the study's authors,
only about 1% of breast cancer patients have a PALB2 gene mutation. ...

http://www.cancer.org/cancer/news/news/researchers-learn-more-about-a-rare-genetic-mutation-linked-to-breast-cancer

Genes, mutations, and cancer risk

... » Genetics and Cancer » Genetic Testing: What You Need to Know » Genes,
mutations, and cancer risk. ... Genes, mutations, and cancer risk. ...

http://www.cancer.org/cancer/cancercauses/geneticsandcancer/genetictesting/genetic-testing-intro

Discovery of New Lung Cancer Mutations May Mean More ...

... mutations present opportunities and impetus for the development of new drugs,
according to Berger. “If you don't have an existing known mutation, ...

http://www.cancer.org/research/acsresearchupdates/lungcancer/discovery-of-new-lung-cancer-mutations-may-mean-more-treatment-options

Do we know what causes breast cancer?

... the women with high-penetrance mutations develop cancer, most cases of
cancer (including breast cancer) are not caused by this kind of mutation. ...

http://www.cancer.org/cancer/breastcancer/detailedguide/breast-cancer-what-causes

Can breast cancer be prevented?

... a BRCA mutation recognize they also have a high risk of developing ovarian
cancer. Most doctors recommend that women with BRCA mutations ...

http://www.cancer.org/cancer/breastcancer/detailedguide/breast-cancer-prevention

New finding may unlock secrets of BRCA mutations

... “Now that researchers can purify the protein, they can create a mutation in
the lab ... There are hundreds of different BRCA mutations, Phelps says. ...

http://www.cancer.org/cancer/news/news/finding-may-unlock-secrets-of-brca-mutations

Breast cancer risk factors you cannot change

... called mutations) inherited from a parent. BRCA1 and BRCA2: The most
common cause of hereditary breast cancer is an inherited mutation in the ...

http://www.cancer.org/cancer/breastcancer/moreinformation/breastcancerearlydetection/breast-cancer-early-detection-risk-factors-you-cannot-change

Gene Mutation Linked to Hereditary Prostate Cancer

... The mutation was found in white families. Two other mutations on the
HOXB13 gene were found in African-American families. ...

http://www.cancer.org/cancer/news/news/gene-mutation-linked-to-hereditary-prostate-cancer

Do we know what causes colorectal cancer?

... In many cases, the first mutation occurs in the APC gene. ... Further mutations
may then occur in genes such as KRAS, TP53, and SMAD4. ...

http://www.cancer.org/cancer/colonandrectumcancer/detailedguide/colorectal-cancer-what-causes