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susceptibility to a disease that can be triggered under certain conditions. For example, some women with close family members who had breast cancer are more likely (but not necessarily destined) to develop breast cancer. Women who inherit a variant of one of the breast cancer genes such as BRCA1 or BRCA2 are also more likely to (but still might not) develop breast cancer. See also BRCA1, BRCA2, hereditary cancer syndrome.