the return of cancer after treatment. Local recurrence means that the cancer has come back at the same place as the original cancer (primary site). Regional recurrence means that the cancer has come back after treatment in the lymph nodes near the primary site. Distant recurrence is when cancer spreads (metastasizes) after treatment to distant organs or tissues (such as the lungs, liver, bone marrow, or brain). See also lymph node, metastasis, metastasize, primary site.