Lymph Node Surgery for Breast Cancer

If breast cancer spreads, it typically goes first to nearby lymph nodes under the arm. It can also sometimes spread to lymph nodes near the collarbone or near the breast bone. Knowing if the cancer has spread to your lymph nodes helps doctors find the best way to treat your cancer.

If you have been diagnosed with breast cancer, it’s important to find out how far the cancer has spread. To help find out if the cancer has spread outside the breast, one or more of the lymph nodes under the arm (axillary lymph nodes) are removed and checked in the lab. This is an important part of staging. If the lymph nodes contain cancer cells, there is a higher chance that cancer cells have also spread to other parts of the body. More imaging tests may be done if this is the case.

Lymph node removal can be done in different ways, depending on whether any lymph nodes are enlarged, how big the breast tumor is, and other factors.

Biopsy of an enlarged lymph node

If any of the lymph nodes under the arm or around the collar bone are swollen, they may be checked for cancer directly with a needle biopsy, either a fine needle aspiration (FNA) or a core needle biopsy. Less often, the enlarged node is removed with surgery. If cancer is found in the lymph node, more nodes will need to be removed during an axillary lymph node dissection (described below).

Types of lymph node surgery

Even if the nearby lymph nodes are not enlarged, they will still need to be checked for cancer. This can be done in two different ways. Sentinel lymph node biopsy (SLNB is the most common and least invasive way, but in some cases a more extensive axillary lymph node dissection (ALND) might be needed.

Lymph node surgery is often done as part of the main surgery to remove the breast cancer, but in some cases it might be done as a separate operation.

Sentinel lymph node biopsy

In a sentinel lymph node biopsy (SLNB), the surgeon finds and removes the first lymph node(s) to which a tumor is likely to spread (called the sentinel nodes). To do this, the surgeon injects a radioactive substance and/or a blue dye into the tumor, the area around it, or the area around the nipple. Lymphatic vessels will carry these substances along the same path that the cancer would likely take. The first lymph node(s) the dye or radioactive substance travels to will be the sentinel node(s).

illustration showing the radioactive substance or dye being injected into tumor with details of the incision and the sentinel node that is removed

After the substance has been injected, the sentinel node(s) can be found either by using a special machine to detect radioactivity in the nodes, or by looking for nodes that have turned blue. To double check, both methods are often used. The surgeon cuts the skin over the area and removes the node(s) containing the dye or radioactivity.

The few removed lymph nodes are then checked closely for cancer cells by a pathologist. Sometimes, this is done during the surgery. Because there is a chance that other lymph nodes in the same area will also have cancer if cancer is found in the sentinel lymph node(s), the surgeon may go ahead with a full axillary dissection (ALND) to remove more lymph nodes while you are still on the operating table. If no cancer cells are seen in the node(s) at the time of the surgery, or if they are not checked by a pathologist at the time of the surgery, they will be examined more closely over the next several days.

If cancer is found in the sentinel node(s) later, the surgeon may recommend a full ALND at a later time to check more nodes for cancer. Studies have shown however that in some cases it may be safe to leave the rest of the lymph nodes behind. This is based on certain factors, such as the size of the breast tumor, what type of surgery is used to remove the tumor, and what treatment is planned after surgery.

Based on the studies that have looked at this, skipping the ALND may be an option for:

  • Women with tumors 5 cm (2 inches) or smaller who have fewer than 3 positive sentinel lymph nodes and are having breast-conserving surgery followed by radiation.
  • Women who have had mastectomy and will also have radiation.

If there is no cancer in the sentinel node(s), it's very unlikely that the cancer has spread to other lymph nodes, so no further lymph node surgery will be needed.

SLNB is often considered for women with early-stage breast cancer and is typically not an option for women with inflammatory breast cancer or locally advanced breast cancer.

Although SLNB has become a common procedure, it requires a great deal of skill. It should be done only by a surgeon who has experience with this technique. If you are offered this type of biopsy, ask your surgeon if they do them regularly.

Axillary lymph node dissection (ALND)

In this procedure, anywhere from about 10 to 40 (though usually less than 20) lymph nodes are removed from the area under the arm (axilla) and checked for cancer spread. ALND is usually done at the same time as a mastectomy or breast-conserving surgery (BCS), but it can be done in a second operation. ALND may be needed:

  • If a previous SLNB has shown 3 or more of the underarm lymph nodes have cancer cells
  • If swollen underarm or collarbone lymph nodes can be felt before surgery or seen on imaging tests and a FNA or core needle biopsy shows cancer
  • If the cancer has grown large enough to extend outside the lymph node(s)
  • If the SLNB is positive for cancer cells after chemotherapy was given to shrink the tumor before surgery

two illustrations showing lymph nodes removed with axillary lymph node dissection and the postoperative appearance

Side effects of lymph node surgery

After lymph node surgery, pain, swelling, bleeding, blood clots, and infection are possible.

Lymphedema

A possible long-term effect of lymph node surgery is swelling in the arm or chest called lymphedema. Because any excess fluid in the arms normally travels back into the bloodstream through the lymphatic system, removing the lymph nodes sometimes blocks drainage from the arm, causing this fluid to build up. 

illustration showing an arm with lymphedema swelling, an unaffected arm and an arm with a compression garment used to help control lymphedema

Lymphedema is less common after a sentinel lymph node biopsy (SLNB) than an axillary lymph node dissection (ALND). The risk is thought to be in the range of 5% to 17% in women who have a SLNB and around 20% to 30% in women who have a ALND. It may be more common if radiation is given after surgery or in women who are obese. Sometimes the swelling lasts for only a few weeks and then goes away. But in some women, it lasts a long time. If your arm is swollen, tight, or painful after lymph node surgery, be sure to tell someone on your cancer care team right away.

Limited arm and shoulder movement

You might also have limited movement in your arm and shoulder after surgery. This is more common after ALND than SLNB. Your doctor may advise exercises to help keep you from having permanent problems (a frozen shoulder).

Some women notice a rope-like structure that begins under the arm and can extend down toward the elbow. This is sometimes called axillary web syndrome or lymphatic cording. It is more common after ALND than SLNB. Symptoms may not appear for weeks or even months after surgery. It can cause pain and limit movement of the arm and shoulder. This often goes away without treatment, although some women may find physical therapy helpful.

Numbness

Numbness of the skin on the upper, inner arm is a common side effect because the nerve that controls sensation here travels through the lymph node area.

The American Cancer Society medical and editorial content team

Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.

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Last Medical Review: September 18, 2019 Last Revised: September 18, 2019

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