Treatment of Localized (Unicentric) Castleman Disease
Surgery is the recommended treatment for people with localized Castleman disease (CD) whenever possible. Removing the abnormal lymph node(s) usually cures the disease. Symptoms such as fever and fatigue that are caused by the CD go away when the lymph node is removed. Relapses are rare.
Sometimes if the diseased area is too large to be removed by surgery, medicines such as corticosteroids or rituximab might be given first. This can shrink the tumor and make it easier to remove.
Radiation can also be used to treat localized CD, either in people who can’t have surgery for some reason or if not all of the disease can be removed with surgery. But it’s not used as often as surgery as the main treatment.
Some patients with localized CD develop secondary amyloidosis, a condition in which abnormal proteins build up in the kidneys, skin, and some other organs. This protein build-up stops once the lymph node affected by CD is removed.
The outlook for localized CD is very good if the affected lymph node(s) can be removed with surgery (or treated with radiation). But sometimes not all of the disease can be removed or treated safely. This doesn’t necessarily mean it will continue to grow and get worse. Even partial removal may help, and the disease may not grow back.
Last Medical Review: July 7, 2014 Last Revised: May 23, 2016
- Surgery for Castleman Disease
- Radiation Therapy for Castleman Disease
- Corticosteroids for Castleman Disease
- Chemotherapy for Castleman Disease
- Immunotherapy for Castleman Disease
- Anti-viral Drugs for Castleman Disease
- Treatment of Localized (Unicentric) Castleman Disease
- Treatment of Multicentric Castleman Disease