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At our National Cancer Information Center trained Cancer Information Specialists can answer questions 24 hours a day, every day of the year to empower you with accurate, up-to-date information to help you make educated health decisions. We connect patients, caregivers, and family members with valuable services and resources.
Or ask us how you can get involved and support the fight against cancer. Some of the topics we can assist with include:
For medical questions, we encourage you to review our information with your doctor.
Hodgkin lymphoma , sometimes called Hodgkin disease, is a cancer that starts in the lymph system in white blood cells called lymphocytes. This cancer can start almost any place in the body.
The lymph system
Ask your doctor to use this picture to show you where the Hodgkin lymphoma is located
The 2 kinds of lymphoma are:
These types of lymphomas are not treated the same way. Be sure to ask your doctor what kind of lymphoma you have.
The lymph system, also known as the lymphatic system, is part of the immune system. (The immune system is how the body fights germs and some diseases.) The lymph system is a network of lymph nodes and certain body parts, such as the spleen, tonsils, and thymus. The parts of the lymph system are connected by tube-like lymph vessels.
Lymph nodes are small, bean-shaped sacs all over the body that help clean germs and cell waste out of the body. Hodgkin lymphoma often starts in lymph nodes, which can be nearly anywhere in the body.
Lymph nodes are made up mainly of lymphocytes, which are a kind of white blood cell. The main types of lymphocytes are B lymphocytes (B cells) and T lymphocytes (T cells). Hodgkin lymphoma almost always starts in B lymphocytes.
There are a few types of Hodgkin lymphoma. The type can affect which treatments are likely to work best. Your doctor can tell you about the kind of Hodgkin lymphoma you have.
Hodgkin lymphoma might cause symptoms like:
Be sure to go for a check-up if you have any of these symptoms.
The doctor will ask you questions about your health and do an exam. The doctor will feel the lymph nodes and other body parts that may be affected. If signs are pointing to Hodgkin lymphoma, more tests will be done. Here are some of the tests you may need:
Biopsy: In this test, the doctor takes out a lymph node or a little bit of tissue to check it for cancer cells. This is often done in a hospital under local anesthesia. This means you’re awake but it’s numb around the lymph node. You may also be given medicine to make you sleepy.
A biopsy is the only way to tell for sure if you have Hodgkin lymphoma. There are many types of biopsies. Ask your doctor what kind you will need. Each type has pros and cons. The choice of which type to use depends on your own case.
Blood tests: Certain blood tests can tell the doctor more about the levels of different types of cells and chemicals in your blood.
Bone marrow aspiration and biopsy: If Hodgkin lymphoma has been found, these tests are done sometimes to tell if it has reached the bone marrow (the soft, inner part of some bones). A doctor uses thin, hollow needles to take out a little bit of bone marrow, most often from the hip bone. The area around the bone is numbed, and you may be given a drug to make you sleep during the test. The samples are sent to a lab to see if there are Hodgkin cells in the bone marrow.
Chest x-rays: X-rays may be done to look for swollen lymph nodes in the chest.
CT scan: This is also called a CAT scan. It’s a kind of x-ray that takes clear pictures to look for swollen lymph nodes or other body parts.
MRI scan: MRIs use radio waves and strong magnets instead of x-rays to take clear pictures. MRIs may be used to look at the spinal cord and brain if the doctor thinks the Hodgkin lymphoma may have spread there.
PET scan: In this test, you are given a type of sugar that can be seen inside your body with a type of camera. If there is cancer, this sugar shows up as “hot spots” where the cancer is found. This test can help show where Hodgkin lymphoma has spread.
If you have Hodgkin lymphoma, the doctor will want to find out how far it has spread. This is called staging. You may have heard someone say that their cancer was stage 1 or stage 2. Your doctor will want to find out the stage of your Hodgkin lymphoma to help decide what type of treatment is best for you.
The stage describes where and how much the Hodgkin lymphoma has spread in your body.
Hodgkin lymphoma can be stage 1, 2, 3, or 4. The lower the number, the less the cancer has spread. A higher number means a worse lymphoma that has spread farther. Be sure to ask the doctor about the stage of your lymphoma and what it means for you.
Most people with Hodgkin lymphoma will get chemotherapy often along with radiation. The treatment plan that is best for you will depend on:
Chemo is the short word for chemotherapy – the use of drugs to fight cancer. The drugs may be given into a vein or taken as pills. These drugs go into the blood and spread all over the body. Chemo is given in cycles or rounds. Each round of treatment is followed by a break. Most of the time, 4 or more chemo drugs are given. Treatment often lasts for many months.
Chemo can have many side effects, like:
These problems tend to go away after treatment ends. There are ways to treat most chemo side effects. If you have side effects, talk to your cancer care team so they can help.
Radiation uses high-energy rays (like x-rays) to kill cancer cells. In some cases, it’s given along with chemo.
For Hodgkin lymphoma, radiation is aimed at the cancer from a machine outside the body. This is called external beam radiation. Radiation therapy works better when the lymphoma is only in one part of the body. Ask your doctor if radiation is part of your treatment plan.
If your doctor says you should have radiation, talk about what side effects might happen. Side effects depend on the part of the body that’s treated. The most common side effects of radiation are:
Most side effects get better after treatment ends. But some side effects might last longer, or might not show up until years later. Talk to your cancer care team about what you can expect.
A stem cell transplant (SCT) lets doctors use very high doses of chemo to kill the Hodgkin cells. The high doses of these drugs destroy the bone marrow, which is where new blood cells are made. Although the drugs destroy the bone marrow, stem cells given after chemo can bring back the blood cell-making bone marrow stem cells. There are different kinds of SCT, each of which can have bad side effects. Ask your doctor which type you will have and what to expect.
Monoclonal antibodies are man-made types of immune system proteins (antibodies) that are given into a vein (IV). Once in the blood, they can attach to a certain place on Hodgkin cells. This can help kill the cells or tell them to die.
These drugs can be given alone or along with chemo. There are different kinds of monoclonal antibodies. Each one can cause different side effects, so ask your doctor what you can expect.
Clinical trials are research studies that test new drugs or other treatments in people. They compare standard treatments with others that may be better.
If you'd like to learn more about clinical trials that might be right for you, start by asking your doctor if your clinic or hospital conducts clinical trials.
Clinical trials are one way to get the newest cancer treatment. They are the best way for doctors to find better ways to treat cancer. If your doctor can find one that’s studying the kind of cancer you have, it’s up to you whether to take part. And if you do sign up for a clinical trial, you can always stop at any time.
When you have cancer you might hear about other ways to treat the cancer or treat your symptoms. These may not always be standard medical treatments. These treatments may be vitamins, herbs, special diets, and other things. You may wonder about these treatments.
Some of these are known to help, but many have not been tested. Some have been shown not to help. A few have even been found to be harmful. Talk to your doctor about anything you’re thinking about using, whether it’s a vitamin, a diet, or anything else.
Even if you have completed treatment, your doctors will still want to watch you closely. It’s very important to go to all your follow-up visits. Follow-up care will be needed for many years after treatment for Hodgkin lymphoma.
During these visits, the doctor will ask about symptoms, do physical exams, and may order blood tests or tests that take pictures inside your body such as CT or PET scans. Most people need doctor visits and tests every few months for the first few years after treatment. Then the longer you’re cancer-free, the less often the visits are needed.
Having cancer and dealing with treatment can be hard, but it can also be a time to look at your life in new ways. You might be thinking about how to better your health. Call us at 1-800-227-2345 or talk to your cancer care team to find out what you can do to feel better.
You can’t change the fact that you have cancer. What you can change is how you live the rest of your life – making healthy choices and feeling as good as you can.
Anyone with cancer, their caregivers, families, and friends, can benefit from help and support. The American Cancer Society offers the Cancer Survivors Network (CSN), a safe place to connect with others who share similar interests and experiences. We also partner with CaringBridge, a free online tool that helps people dealing with illnesses like cancer stay in touch with their friends, family members, and support network by creating their own personal page where they share their journey and health updates.
The American Cancer Society medical and editorial content team
Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.
Biopsy (BY-op-see): Taking out a small piece of tissue to see if there are cancer cells in it.
Immune system: The body system that fights infection.
Lymph (limf) nodes: Small, bean-shaped collections of immune system tissue found all over the body and connected by lymph vessels; also called lymph glands.
Lymph system: The tissues and organs (including lymph nodes, spleen, thymus, and bone marrow) that make and store lymphocytes (white blood cells that fight infection) and the channels or vessels that carry the lymph fluid; also known as the lymphatic system.
Lymphocyte (LIM-fo-site): A type of white blood cell that helps fight infection; also the cell in which Hodgkin lymphoma starts.
Lymphoma (lim-FOAM-uh): A cancer that starts in the lymph system, a network of thin vessels and nodes throughout the body that helps to fight infection. The 2 main types of lymphoma are Hodgkin lymphoma (Hodgkin disease) and non-Hodgkin lymphoma.
We have a lot more information for you. You can find it online at www.cancer.org. Or, you can call our toll-free number at 1-800-227-2345 to talk to one of our cancer information specialists.
Last Revised: May 1, 2018
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