About the Guidelines

How the Guidelines Are Created

The ACS develops guidelines for cancer screening and prevention to meet the needs of clinicians, the general public, and policy. 

Screening Guidelines Development Process

Since 1980, the American Cancer Society (ACS) has introduced and periodically updated guidelines or guidance related to screening and/or informed decision-making about tests for early detection of cancers (and, in some cases, precursor lesions) of the breast, cervix, colon and rectum, endometrium, lung, and prostate. These screening guidelines have evolved with new scientific data, as new screening technologies became available, and as standards for creating guidelines changed. 

Read more about our screening guideline creation process. 

Prevention Guidelines Development Process

For those who do not use tobacco, weight control, dietary choices, and levels of physical activity are the most important modifiable determinants of cancer risk. Our guidelines reflect the most current scientific evidence related to dietary and activity patterns and cancer risk. They focus on recommendations for individual choices but also present recommendations for community action to create a supportive social and physical environment in which individuals have genuine opportunities to choose healthy behaviors.

Highlights

These guidelines address the populations for whom testing is recommended or not recommended, the recommended tests and testing intervals, and the benefits, limitations, and harms associated with testing for early cancer detection. 

  • ACS guidelines for the early detection of cancer in average-risk adults endorse screening for breast cancer, cervical cancer, and colorectal cancer. 
  • ACS recommends informed and/or shared decision-making for adults men considering prostate cancer screening based on uncertainties and differing values about the uncertainty of the balance of benefits and harms.
  • ACS lung cancer screening guidelines also stress informed and shared decision-making. 
  • ACS guidelines for risk reduction and prevention include recommendations for nutrition and physical activity and for use of the human papillomavirus (HPV) vaccine.

Current Guidelines

Breast Cancer

The American Cancer Society recommends that women undergo regular screening mammography for the early detection of breast cancer.

Cervical Cancer

This joint guideline from the American Cancer Society, the American Society for Colposcopy and Cervical Pathology, and the American Society for Clinical Pathology recommends different surveillance strategies and options based on a woman’s age, screening history, other risk factors, and the choice of screening tests.

Colorectal Cancer

The American Cancer Society recommends that adults at average risk for colorectal cancer undergo regular screening starting at age 45, with either a high-sensitivity stool-based test or a structural (visual) examination.  As a part of the screening process, all positive results on non-colonoscopy screening tests should be followed up with timely colonoscopy.

Endometrial Cancer

On reaching menopause, all women should be informed about the risks and symptoms of endometrial cancer and strongly encouraged to report any unexpected bleeding or spotting to their physicians. There is no evidence, however, to support the screening of asymptomatic women and some evidence against screening. Women with or at risk for HNPCC should be offered screening annually by age 35.

Lung Cancer

The American Cancer Society recommends annual screening for lung cancer with low-dose CT in adults aged 55 to 74 years in
relatively good health who have at least a 30-pack-year smoking history, currently smoke or have quit within the past 15 years, receive evidence-based smoking cessation counseling, if they are current smokers, have undergone a process of informed/shared decision making that included information about the benefits, limitations, and harms of screening with LDCT, and have access to a high-volume, high-quality lung cancer screening and treatment center. Core elements of a clinician-patient discussion are provided to enable informed and shared
decision making.

Prostate Cancer

The American Cancer Society recommends that asymptomatic men who have at least a 10-year life expectancy have an opportunity to make an informed decision with their health care provider about screening for prostate cancer after they receive information about the uncertainties, risks, and potential benefits associated with prostate cancer screening. The guideline provides detailed recommendations for clinicians concerning the core factors related to prostate cancer screening and treatment that should be shared with men to enable them to make a truly informed decision regarding whether to be screened.

Nutrition and Physical Activity Guidelines

Since 1991, the American Cancer Society has published Nutrition and Physical Activity guidelines to advise health care professionals, policy makers, and the general public about dietary and other lifestyle practices that reduce cancer risk. These guidelines provide a summary of the existing scientific information about weight control, physical activity, and nutrition in relation to cancer.

In addition to recommendations regarding individual choices, the ACS guidelines underscore what communities can and should do to facilitate healthy eating and physical activity behaviors.

Nutrition and Physical Activity Guidelines for Cancer Survivors provide health care providers with the best possible information with which to help cancer survivors and their families make informed choices related to nutrition and physical activity, to improve treatment outcomes, quality of life, and overall survival.
 

Vaccine Guidelines

The American Cancer Society recommends routine HPV vaccination for females and males starting at age 11 or 12 years.