On reaching menopause, all women should be informed about the risks and symptoms of endometrial cancer and strongly encouraged to report any unexpected bleeding or spotting to their physicians. There is no evidence, however, to support the screening of asymptomatic women and some evidence against screening. Women with or at risk for HNPCC should be offered screening annually by age 35.
Full text of current ACS recommendations (and rationale) for testing for early endometrial cancer detection, including recommendations for women at high risk, is available here.