Physical symptoms in the last 2 to 3 months of life

This is written for the person with cancer, but it can be helpful to the people who care for, love, and support someone with advanced cancer, too. This information may help you find answers to your questions and concerns during this very sensitive and difficult time.

This is a list of some of the things a person goes through as death gets closer. We also try to give some tips on what can be done to help manage these symptoms. Be sure to tell your health care team how you are doing. Don’t assume it’s normal to feel bad. There are often things that can be done to help you feel better.


Scott, age 60, with advanced cancer: “I feel like an engine running out of steam. It seems like I have just enough energy to do one or two small things, then it’s gone. I have used up my supply for that day. I get tired of being tired. It’s so frustrating!”

Fatigue is the feeling of being tired physically, mentally, and emotionally. Cancer-related fatigue is often defined as an unusual and ongoing sense of extreme tiredness that doesn’t get better with rest. Almost everyone with advanced cancer has this symptom.

What can you do about fatigue?

To manage fatigue, first, control the symptoms that make it worse, like pain or constipation. Then you can help prevent more fatigue by carefully balancing rest and activity. Your health care team and your caregivers can help you find ways to manage the things that can make you feel more fatigued. Tell them how you feel, and try different things to see if they help you feel less tired.

Some medicines can make you feel tired, too. You may need to talk with your team about switching to new ones or taking them at different times. You might even be able to stop taking drugs that aren’t helping or aren’t needed any more.

Keep safe when you’re active. If you’re unsteady on your feet, make sure you have help when walking. You may feel safer if you have a walker or wheelchair. Your doctor or hospice team can help you get the equipment you need to be comfortable and safe.

Plan activities around the times you feel the best and have the most energy. Sit outside, listen to music, go for a ride in the car, spend time watching a meal being prepared – distractions and stimulation of your senses may help ease fatigue.

Some people find a bedside commode or toilet chair helps – they don’t waste energy traveling to and from the bathroom. Plan rest stops when you are out of bed so that you can sit to regain energy. Take short rests during activity – keep chairs close by.

Some people may find that they’re afraid to go to sleep because they’re afraid they won’t wake up again. Again, this is a natural and very real fear. Needing more sleep is normal in the last few months of life. Withdrawing from people, turning inward, focusing on yourself, and talking less are also common at this time. Although some people want to surround themselves with friends and family, others want a quiet, peaceful environment. Listen to your body, tell people what you need, and save your energy for the things or people that are most important to you. Focusing on getting the most from each waking moment is a good way to redirect your worries and fears.


John, age 47: “I need the morphine to do the things I want to do. As long as I lay still in bed, I’m okay – no pain, but I don’t want to spend the rest of my life flat on my back in bed!”

People with cancer often fear pain more than anything else. Pain can make you feel irritable, sleep poorly, decrease your appetite, and decrease your concentration, among many other things. But pain can be controlled and managed in expert hands. It’s important to know that pain does not have to be a part of dying. If you have pain, it’s very important to talk to your health care team about it. They should understand that your pain is whatever you say it is. You should expect that your pain can and will be controlled. You and your team must work together to reduce suffering, relieve pain, and enhance your quality of life.

Your health care team should check in with you often to find out how much pain you’re having. It’s important to keep them up to date on all changes in your pain and other symptoms. They’ll need you to tell them how well each pain control plan work is working. Don’t be discouraged if your medicines must be tweaked a few times to get the best pain control with the fewest side effects. You may want to ask your team to refer you to a pain specialist if your pain isn’t being controlled.

Describe your pain in as much detail as you can, including:

  • Where it is
  • What it feels like
  • How long it lasts
  • When it started
  • What makes it better
  • What makes it worse.

Keeping a pain record of all of this may help. Often your health care team will ask you to describe your pain using a number from 0 to 10, with 10 being the worst pain you can imagine and 0 being no pain at all. Using this pain scale is also a helpful way to describe your response to pain relief measures. You can find a Daily Pain Diary and a lot more information on pain control online or call us for free copies.

Types of pain medicines

The nurse or doctor will assess your pain and figure out the average level or degree of pain you have. There are a lot of different pain medicines available ranging from acetaminophen (Tylenol®) to opioids (morphine-like drugs).

There are also many forms of pain medicine, such as long-acting, time-released forms of opioids that are around the clock. These long-acting drugs work by keeping your blood levels of the drug steady, which helps keep your pain under control for long periods of time. Fast-acting, rescue drugs can be used to quickly control pain.

Opioid pain medicines come in many forms that can be given in many different ways. Patches that stick to the skin, lozenges or “suckers” that don’t have to be swallowed, drops that go under the tongue, and even rectal suppositories can be used when needed.

Sometimes, very severe pain may be better controlled with a pain medicine pump which gives the drugs either under the skin (subcutaneously) or into a vein (intravenously, IV). If you need this type of pain control, you can still get it at home.

It’s very common for a person with cancer to take more than one drug to manage chronic and breakthrough pain. And some people need much higher doses of opioids than others. Don’t be concerned if you seem to be taking large amounts of drugs. It has nothing to do with being unable to withstand pain, nor does it mean that you are a complainer. Some people need less, and some need more to keep pain in check.

Over time you may also find that you need higher doses of pain medicines because they aren’t working as well as they once did. This is because the body can become tolerant to a drug, so it has less effect. Needing to increase your pain medicine does not mean that you are going to die soon. In fact, evidence has shown that poor pain relief hastens death.

Sometimes other drugs may be used. For instance, certain anti-depressants or anti-convulsants (seizure control drugs) often work well to help with nerve pain. Steroids may be used to help with certain types of pain, such as that caused by swelling or inflammation. These medicines are often given along with the opioid drugs.

Signs that a person is in pain

If the patient is not able to talk about the pain they may be having, there are things caregivers can watch for that show pain or discomfort. Some signs of pain they may see include:

  • Noisy breathing – labored, harsh, or rapid breaths
  • Making pained sounds – including groaning, moaning, or expressing hurt
  • Facial expressions – looking sad, tense, or frightened; frowning or crying
  • Body language – tension, clenched fists, knees pulled up, inflexibility, restlessness, or looking like they’re trying to get away from the hurt area
  • Body movement – changing positions to get comfortable but can’t

Being able to identify these things and give pain medicine as needed helps the caregiver take good care of the patient and keep him or her as comfortable as possible.

Other ways to help cancer pain

With certain types of pain, doctors can do special procedures such as nerve blocks, targeted radiation treatments, or even surgical procedures to control pain. If your pain isn’t well controlled, your doctor might also refer you to an expert in pain management. The pain specialist might have some different options to help you.

Medicines and medical procedures are not the only ways to help lessen your pain. There are other things you can do. Some people find distractions like music, movies, conversation, or games help. Using heat, cold, or massage on a painful area can help. Relaxation exercises and meditation can help lessen the pain and lower anxiety for some people. Keep in mind that for most people with cancer pain these measures alone are not enough to control pain. But, they may help improve comfort when used along with pain medicines.

Appetite changes

Margie, age 34: “I just can’t eat, but I know I have to eat to live. It upsets my husband and my kids when I don’t…it scares me too sometimes. I try, but I can’t do it.”

As time goes on your body may seem to be slowing down. Maybe you’re feeling more tired or maybe the pain is getting worse. You may become more withdrawn and find yourself eating less and losing weight. This is a normal part of the last months of life, but it may be the start of a battle between you and your loved ones.

You’re moving less, have less energy, less appetite, and less desire to eat. Food no longer smells good or tastes good. You seem to become full more quickly and are interested in fewer foods. While this is going on, the cancer cells may compete with the normal cells in your body for the nutrients that you do manage to digest.

Avoid family food battles

It can be very upsetting to your family to see you eating less. For them, your interest in food may represent your interest in life. By refusing food, it may seem to your family that you’re choosing to shorten your life. They may take this personally and think that you want to leave them or are trying to hasten your death – even unconsciously.

It’s important that you and your loved ones talk about issues around eating. The last few months of your life should not be filled with battles around food. Loss of appetite and being unable to eat happens to most cancer patients before death. It’s normal in the last months of life for parts of your body to start slowing down and eventually shut down. When you feel like eating less, it’s not a sign that you want to leave life or your family. It’s just a normal part of the dying process. Explain to your loved ones that you deeply appreciate all their efforts to feed you and that you understand their attempts are acts of love. You’re not rejecting their love, but your body is limiting what it needs at this time.

Your body is going through changes that have a direct effect on your appetite. Changes in taste and smell, dry mouth, stomach and bowel changes, shortness of breath, nausea, vomiting, diarrhea, constipation – these are just a few of the things that make it harder to eat. Drug side effects, stress, and spiritual distress are also possible causes of poor appetite.

Some causes can be managed with medical treatment. For example, nutritional support can be given in the form of tips on how to get the most out of each bite you take or through supplemental drinks or shakes. There are also medicines that can stimulate your appetite, decrease nausea, and help food move through your stomach more quickly. You might be surprised to find that you’re able to eat more when others are at the table. You may be able to take small frequent meals or snacks during the day instead of trying to eat full meals 3 times a day. These measures may work for some, but they won’t help most people who are very close to the end of life. (See “ When death is near.”) At later stages, these efforts can even make the person feel worse.

It’s important to recognize changes in appetite so that you can get help when it’s needed. Talk to your medical team about how much you’ve been eating and whether you need to do something about it.

Problems breathing

Henry, age 78: “I was struggling to breathe. I thought the attack would never end and that was how I was going to die!”

Even thinking about breathing problems can be scary. Trouble breathing and/or shortness of breath is very common in people with advanced cancer, but it can be managed at the end of life.

You may feel short of breath or like you need to breathe faster and harder than normal. You might feel like you have liquid in your lungs and it makes you want to cough. Often these symptoms come and go. Tell your health care team if you’re having any problems breathing so you can get help with them.

A number of things can be done to make it easier for you to breathe:

  • Sitting up
  • Propping yourself up on pillows
  • Leaning over a table
  • Sometimes oxygen coming through a small tube you wear under your nose will relieve most of your symptoms
  • Opioid pain medicines can work well to decrease shortness of breath and relax your breathing.
  • If there’s fluid in your lungs, medicines can be given to slow the fluid build-up.
  • Sometimes opening a window, a cooler room temperature, or having a fan blowing on your face will help you feel less hungry for air
  • You can be taught breathing and relaxation techniques to use when breathing is hard
  • Medicines to reduce anxiety may help you worry less about shortness of breath

Many people with cancer fear that this problem will get worse as the disease progresses. There are steps to manage each change in your condition and treat each problem. Just like pain, your health care team should be able to help with your breathing problems.

The American Cancer Society medical and editorial content team

Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.

Coyle N and Ferrell BR. Textbook of Palliative Nursing. New York: New York, Oxford University Press. 2001.

Foley KM, Back A, Bruera E, et al. When the Focus is on Care: Palliative Care and Cancer. Atlanta, Georgia: American Cancer Society. 2005.

National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology. Palliative Care – Version 1.2016. Accessed at on April 26, 2016.

Last Medical Review: April 29, 2016 Last Revised: June 8, 2016





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