How Cancer And Cancer Treatment Can Affect Fertility

What is fertility?

Fertility refers to having the ability to conceive, or being able to have a child. For females, fertility means they are able to become pregnant through normal sexual activity, and they are able to carry the baby through pregnancy. For males, fertility means they are able to father a child through normal sexual activity. A person's fertility depends on their reproductive organs working properly and other factors, such as when and how often they are having sex, certain hormones, and if their partner has any problems with fertility.

When a person cannot have a child, this is called infertility, or being infertile.

  • For females, infertility can mean they are not able to get pregnant through normal sexual activity or they have problems carrying a baby through a full-term pregnancy.
  • For males, infertility means they are not able to father a child through normal sexual activity.

Doctors usually consider someone to be infertile if they haven't been able to conceive a child after 12 or more months of regular sexual activity, or after 6 months if the woman is more than 35 years old.

Problems with fertility can also be called reproductive problems or alterations. They happen when certain hormone levels are abnormally low or high or if sex organs are removed or aren't working properly. Some people never find out why they are having fertility problems. Many experts believe stress and anxiety can cause changes that play a part in infertility.

Fertility and cancer

Cancer – and treatment for cancer – can sometimes make having a child more difficult, or can raise doubts about whether having children is the right thing to do. People with certain types of cancer or those who are getting treatment for cancer may have these doubts or experience fertility problems. The problems might be caused by:

  • A tumor directly damaging an organ or its surrounding tissue
  • Removing cancerous organs that normally would be needed to have a child (for example, cancer surgery might be needed to remove all or part of the testicles, penis, ovaries, uterus, or cervix.)
  • Certain treatments for cancer that can change hormone levels, put a woman into early menopause, damage nerves, or make certain sex organs stop working properly
  • Psychological or emotional responses, such as stress and anxiety

Any of these situations can lead to serious concerns about fertility when treatment ends.

Fertility issues in children who have cancer

Children and teenagers who have cancer are often of special concern. This is because they might have surgery or get treatments that can damage their growing and maturing organs, and some can affect their hormone and sexual development. Having these things happen in their younger years can affect fertility later in life. You can read more about this in Late Effects of Childhood Cancer Treatment.

Birth defects from cancer treatment

Sometimes fertility is not affected by cancer treatment, but there can be concern about birth defects if a pregnancy happens during or after treatment. Studies show there is a risk of birth defects when a woman becomes pregnant while getting or after receiving some types of chemotherapy, radiation therapy, and hormone therapy. In some cases, the risk can last for a long time, making getting pregnant a concern even years after treatment ends. In general, women are usually advised to not to get pregnant during treatment and may be told it's best not to get pregnant afterwards, depending on the treatment and situation.

The risk for birth defects when a man fathers a child during or after having treatment is not as clear. Many doctors advise men who are getting treatment to use birth control and not try to father a baby during treatment, just in case.

Talking about infertility when you have cancer

If fertility problems are possible, or there might be risks to having a baby after treatment, it's important to talk with the doctor and other members of the health care team about risks and available options.

Don't assume your doctor or nurse will ask you about these things or if fertility is important to you. You might need to start the conversation. Studies have found that doctors, nurses, and other members of a health care team don’t always ask about these problems during check-ups and treatment visits. Because of this, patients might not get enough information, support, or resources to help them deal with fertility problems.

Studies also show that many doctors and nurses don't know the right questions to ask about sexual orientation and gender identity. Many are not familiar with different terms that describe a person as lesbian, gay, bisexual, transgender (LGBT), or gender non-conforming (GNC). It's very important to let your cancer care team know your sexual orientation and gender identity, including what gender you were at birth and how you describe yourself now. Letting your cancer care team know this information will help you get the personalized care you need.

Experts recommend that doctors who are part of the cancer care team be involved in talking about fertility with patients, including medical oncologists, radiation oncologists, gynecologic oncologists, urologists, hematologists, pediatric oncologists, surgeons, nurses, and others. The cancer care team should talk about any possible fertility problems that might happen due to treatment as early as possible, either before surgery or before treatment starts. These conversations should consider your preferences, religious or personal beliefs, and the cost of available options. You might want to get a second opinion, or get a referral to a fertility or reproductive specialist.

For adult patients

Depending on your age, personal choices, family situation, and stage of life, being able to have a child (or another child) may be important to you. If so, be sure to talk to your cancer care team about how your cancer, any needed surgeries and procedures, and treatments and medications might affect your fertility. This includes letting them know what over-the-counter and prescription medications, vitamins, or supplements you may be taking because they might interfere with treatments.

Be as honest and open as possible, and ask questions so your cancer care team can help. Once a conversation has been started, it's easier to continue it and to bring it up again during your future check-ups.

Most importantly, talk with your partner about your concerns. Get as much information as you can, so you can decide together how to approach any fertility problems that are expected or might come up during and after treatment. If you are both comfortable with it, it might be a good idea to include your partner when talking with your health care team, too.

Talking to others, such as friends, family members, and other cancer survivors can be helpful. But, it's important to remember that everyone is different, and one person's experience may be very different from yours. Not everyone's cancer or treatment will affect them in the same way. Different types of cancer and treatments have different side effects, and effects on fertility can often depend on the patient's maturity and stage in life. How a body reacts can be better or worse depending on other health problems, too.

Your doctor may refer you to a counselor, therapist, or fertility specialist that can help you talk about options, and deal with some fears and worries about the effects of cancer on your fertility.

For parents of children with cancer

It's very important for parents of children, teenagers, and young adults to be told about effects on fertility soon after a diagnosis, and before treatment starts. Depending on the situation, options might be available to help preserve fertility. You can read more about this in Late Effects of Childhood Cancer Treatment.

For caregivers and partners

Concerns about fertility are often shared by people with cancer and their partners. Support is very important. Depending on the situation and your desire for having children, you can work together to find possible options for preserving fertility or for having a child once treatment ends. This can help to reassure the patient and help you both cope with the changes that are happening and challenges that lie ahead. Going with the patient to treatment and follow-up visits and check-ups might be a good idea, too. You might want to think about asking for a referral to a counselor, therapist, or fertility specialist.

Before surgery or treatment

Parents of children with cancer, and adult patients and their partners need to know about possible fertility problems before having surgery and other treatments. Having these talks in advance can help know what to expect. But, studies show that not many cancer patients remember being told about fertility risks before surgery or treatment. Asking questions and getting honest answers can open up the opportunity for follow-up talks that lead to making informed decisions about care through the entire cancer journey and later in life.  

During cancer treatment

You may have concerns about fertility during treatment, or may notice changes in your body that you think might affect your ability to have children after treatment. It's important to keep talking to your health care team as you move into the treatment phase. Or, if you didn't talk about fertility before surgery or treatment, you can start talking about it during treatment-related visits, even if your doctor or nurse don't bring it up. Include your partner, if you're comfortable doing so. Remember, if your health care team doesn't know about a problem you're having, they can't help you manage it.

After cancer treatment

People who have finished cancer treatment may have lingering problems that affect fertility, and some might be lifelong. These can affect relationships, too. Be sure to continue reporting problems and asking questions during follow-up visits. If you are no longer managed by a cancer care team, be sure those providing health care for you are aware of problems you've had, what has helped or not helped, and other problems that might come up. Seeing a fertility specialist might be beneficial.

Palliative care

Palliative care can help address quality-of-life concerns. Ask members of a palliative care team to help manage fertility problems. This team of professionals can help manage symptoms at any time from the point of diagnosis, throughout treatment, and beyond for people living with a serious illness, such as cancer, no matter what stage it is.

The American Cancer Society medical and editorial content team

Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.

Agency for Healthcare Quality and Research (AHRQ). Comparative effectiveness review: Management of infertility evidence summary. 2019;AHRQ Pub. No.19-EHC014-1-EF.

Centers for Disease Control and Prevention (CDC). About LGBT Health. Accessed at https://www.cdc.gov/lgbthealth/about.htm on January 31, 2020.

Mitsis D, Beaupin LK, O’Connor T. Reproductive complications. In Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff’s Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:665-675.

Moment A. Sexuality, intimacy, and cancer. In Abrahm JL, ed. A Physician’s Guide to Pain and Symptom Management in Cancer Patients. Baltimore, MD: Johns Hopkins University Press; 2014:390-426.

National Comprehensive Cancer Network (NCCN). Clinical practice guidelines in oncology: Survivorship [Version 2.2019]. Accessed at https://www.nccn.org/professionals/physician_gls/pdf/survivorship.pdf on January 31, 2020.

Nishimoto PW, Mark DD. Sexuality and reproductive issues. In Brown CG, ed. A Guide to Oncology Symptom Management. 2nd ed. Pittsburgh, PA: Oncology Nursing Society; 2015:551-597.

Oktay et al. Fertility preservation in patients with cancer: American Society of Clinical Oncology clinical practice guideline update. Journal of Clinical Oncology. 2018;36(19):1994-2003.

Patounakis G, Christy AY, DeCherney AH. Gonadal dysfunction. In DeVita VT, Lawrence TS, Rosenberg SA, eds. DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology. 11th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2019:2133-2148.

Scime S. Inequities in cancer care among transgender people: Recommendations for change. Canadian Oncology Nursing Journal. 2019;29(2):87-91.

U.S. Department of Health and Human Services, National Institutes of Health (NIH). Fertility and infertility. Accessed at https://www.nichd.nih.gov/health/topics/infertility on January 31, 2020.

References

Agency for Healthcare Quality and Research (AHRQ). Comparative effectiveness review: Management of infertility evidence summary. 2019;AHRQ Pub. No.19-EHC014-1-EF.

Centers for Disease Control and Prevention (CDC). About LGBT Health. Accessed at https://www.cdc.gov/lgbthealth/about.htm on January 31, 2020.

Mitsis D, Beaupin LK, O’Connor T. Reproductive complications. In Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff’s Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:665-675.

Moment A. Sexuality, intimacy, and cancer. In Abrahm JL, ed. A Physician’s Guide to Pain and Symptom Management in Cancer Patients. Baltimore, MD: Johns Hopkins University Press; 2014:390-426.

National Comprehensive Cancer Network (NCCN). Clinical practice guidelines in oncology: Survivorship [Version 2.2019]. Accessed at https://www.nccn.org/professionals/physician_gls/pdf/survivorship.pdf on January 31, 2020.

Nishimoto PW, Mark DD. Sexuality and reproductive issues. In Brown CG, ed. A Guide to Oncology Symptom Management. 2nd ed. Pittsburgh, PA: Oncology Nursing Society; 2015:551-597.

Oktay et al. Fertility preservation in patients with cancer: American Society of Clinical Oncology clinical practice guideline update. Journal of Clinical Oncology. 2018;36(19):1994-2003.

Patounakis G, Christy AY, DeCherney AH. Gonadal dysfunction. In DeVita VT, Lawrence TS, Rosenberg SA, eds. DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology. 11th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2019:2133-2148.

Scime S. Inequities in cancer care among transgender people: Recommendations for change. Canadian Oncology Nursing Journal. 2019;29(2):87-91.

U.S. Department of Health and Human Services, National Institutes of Health (NIH). Fertility and infertility. Accessed at https://www.nichd.nih.gov/health/topics/infertility on January 31, 2020.

Last Medical Review: February 5, 2020 Last Revised: February 5, 2020

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