Stages of Non-Hodgkin Lymphoma in Children
What is the stage of a lymphoma?
A lymphoma's stage is the extent of the disease at the time of diagnosis. The treatment and prognosis (outlook) for a child with non-Hodgkin lymphoma (NHL) depend, to a large extent, on the lymphoma’s stage.
The stage is based on the results of physical exams, biopsies, and imaging tests (CT scan, PET scan, etc.), which are described in Tests for Non-Hodgkin Lymphoma in Children.
A staging system is a standard way for the cancer care team to describe how far a cancer has spread. The staging system most often used to describe the spread of NHL in children is called the St. Jude staging system. This is different from the staging system used for lymphomas in adults.
St. Jude staging system
The St. Jude system divides NHL in children into 4 stages:
- Stage I and II lymphomas are usually considered limited-stage disease and are treated the same way.
- Stage III and IV lymphomas are usually thought of as advanced-stage disease and are also treated alike.
Stage I
The lymphoma is in only one place, either as a single tumor not in lymph nodes, or in lymph nodes in one part of the body (the neck, groin, underarm, etc.). The lymphoma is not in the chest or abdomen (belly).
Stage II
Stage II lymphomas are not in the chest, and one of the following applies:
- The lymphoma is a single tumor and is also in nearby lymph nodes in only one part of the body (the neck, groin, underarm, etc.).
- The lymphoma is more than one tumor and/or in more than one set of lymph nodes, all of which are either above or below the diaphragm (the thin breathing muscle that separates the chest and abdomen). For example, this might mean nodes in the underarm and neck area are affected but not the combination of underarm and groin nodes.
- The lymphoma started in the digestive tract (usually at the end of the small intestine) and can be removed by surgery. It might or might not have reached nearby lymph nodes.
Stage III
For stage III lymphomas, one of the following applies:
- The lymphoma started in the chest (usually in the thymus or lymph nodes in the center of the chest or the lining of the lung).
- The lymphoma started in the abdomen and has spread too widely within the abdomen to be removed completely by surgery.
- The lymphoma is located next to the spine (and may be elsewhere as well).
- The lymphoma is more than one tumor or in more than one set of lymph nodes that are both above and below the diaphragm. For example, the lymphoma is in both underarm and groin lymph nodes.
Stage IV
The lymphoma is in the central nervous system (brain or spinal cord) and/or the bone marrow when it is first found. (If more than 25% of the bone marrow is made up of cancer cells, called blasts, the cancer is classified as acute lymphoblastic leukemia [ALL] instead of lymphoma.)
Last Revised: August 3, 2017
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Early Detection, Diagnosis, and Staging
- Can Non-Hodgkin Lymphoma in Children Be Found Early?
- Signs and Symptoms of Non-Hodgkin Lymphoma in Children
- Tests for Non-Hodgkin Lymphoma in Children
- Stages of Non-Hodgkin Lymphoma in Children
- Survival Rates for Childhood Non-Hodgkin Lymphoma
- What Should You Ask Your Child’s Doctor About Non-Hodgkin Lymphoma?