Signs and Symptoms of Salivary Gland Cancer

Most salivary gland cancers are found because of symptoms they cause, but many of these symptoms can be caused by conditions other than cancer.

General symptoms

The major salivary glands are on each side of the face and below the tongue. The minor salivary glands are in the mouth, nose, and sinuses.

Several important nerves and other structures run through or near the larger major salivary glands. If a tumor affects these nerves or structures, it can cause symptoms.

Possible signs and symptoms of salivary gland cancer include:

  • A lump or swelling in your mouth, cheek, jaw, or neck
  • A recent difference between the size and/or shape of the left and right sides of your face or neck
  • An ulcer in the nose, roof of the mouth, cheek, or lips that doesn’t go away
  • Numbness in part of your face
  • Weakness of the muscles on one side of your face
  • Pain in your mouth, cheek, jaw, ear, or neck that does not go away
  • Trouble opening your mouth all the way
  • Trouble swallowing

Many of these signs and symptoms can also be caused by benign (noncancerous) salivary gland tumors or by other conditions. Still, if you have any of these problems, it’s important to see your doctor right away so the cause can be found and treated if needed.

side by side logos for American Cancer Society and American Society of Clinical Oncology

Developed by the American Cancer Society medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).

Laurie SA. Salivary gland tumors: Epidemiology, diagnosis, evaluation, and staging. UpToDate. 2025. Accessed at https://www.uptodate.com/contents/salivary-gland-tumors-epidemiology-diagnosis-evaluation-and-staging on January 8, 2026.

Leeman JE, Katabi N, Wong RJ, Lee NY, Romesser PB. Chapter 65: Cancer of the Head and Neck. In: Niederhuber JE, Armitage JO, Dorshow JH, Kastan MB, Tepper JE, eds. Abeloff’s Clinical Oncology. 6th ed. Philadelphia, Pa. Elsevier: 2020.

National Cancer Institute. Salivary Gland Cancer Treatment. Accessed at https://www.cancer.gov/types/head-and-neck/hp/adult/salivary-gland-treatment-pdq on January 8, 2025.

Sirjani DB, Lewis JS, Beadle BM, Sunwoo JB, Finegersh A. Chapter 86: Malignant Neoplasms of the Salivary Glands. In: Francis HW, Haughey BH, Hillel AT, eds. Cummings Otolaryngology: Head and Neck Surgery. 8th ed. Philadelphia, PA. Elsevier; 2026.

Last Revised: March 11, 2026

American Cancer Society Emails

Sign up to stay up-to-date with news, valuable information, and ways to get involved with the American Cancer Society.