Chemotherapy for Malignant Mesothelioma

Chemotherapy (chemo) is treatment with anti-cancer drugs.

Uses of chemotherapy

For mesotheliomas that can be treated with surgery, chemo may be given before surgery to try to shrink the cancer and lower the risk of spread. This is called neoadjuvant therapy.

Chemo can also be given after surgery to try to kill any cancer cells that were left behind. This type of treatment, called adjuvant therapy, may help delay or prevent the cancer growing back.

For cancers that can’t be removed with surgery, chemo may be the main treatment (alone or along with radiation therapy). Chemo may shrink the cancer or slow its growth, but it is very unlikely to make it go away completely.

How chemotherapy is given

Doctors usually give chemo in cycles, with each period of treatment followed by a rest period to allow the body time to recover. Chemo cycles generally last about 3 to 4 weeks. Chemo is often not recommended for patients in poor health, but advanced age by itself is not a barrier to getting it.

There are 2 main ways chemo can be given to treat mesothelioma.

In systemic therapy, chemo is injected into a vein. The drug enters the bloodstream and travels throughout the body to reach and destroy the cancer cells wherever they may be.

Chemo drugs can also be placed directly into the body space where the cancer is – either intrapleurally (directly into the chest) or intraperitoneally (into the abdomen). This is done with a small catheter (tube) placed through a small cut in the chest or abdominal wall. Chemo drugs given this way are still absorbed into the bloodstream, but the highest concentrations of the drugs go directly to where the cancer cells are.

For intrapleural or intraperitoneal chemo, the drugs are sometimes heated before they are put directly into a body space (called hyperthermic chemotherapy), which may help them work better. Sometimes this treatment is given as a single dose in the operating room, right after surgery to remove the cancer. This approach is called heated intraoperative chemotherapy. It is more often used to treat peritoneal cancers, in which case it may be called heated intraperitoneal chemotherapy or HIPEC.

Chemotherapy drugs used for mesothelioma

Several chemo drugs can be used to treat mesothelioma, including:

  • Pemetrexed (Alimta®)
  • Cisplatin
  • Carboplatin
  • Gemcitabine (Gemzar®)
  • Methotrexate
  • Vinorelbine
  • Mitomycin
  • Doxorubicin (Adriamycin®)

These may be given as combinations of 2 drugs, but single drugs can be used in people who may not be able to tolerate more than one drug.

When 2 drugs are used, most doctors give pemetrexed and cisplatin. Pemetrexed lowers levels of folic acid and vitamin B12 in the body, so patients get these as well to help avoid certain side effects. Other possible combinations include pemetrexed with carboplatin, or cisplatin with gemcitabine.

For HIPEC, either mitomycin or the combination of cisplatin plus doxorubicin is most often used.

Possible side effects

Chemo drugs attack cells that are dividing quickly, which is why they work against cancer cells. But other cells in the body, such as those in the bone marrow (where new blood cell are made), the lining of the mouth and intestines, and the hair follicles, also divide quickly. These cells are also likely to be affected by chemo, which can lead to side effects.

The side effects of chemo depend on the type and dose of drugs given and how long they are used for. Common side effects include:

  • Hair loss
  • Mouth sores
  • Loss of appetite
  • Nausea and vomiting
  • Diarrhea
  • Increased chance of infections (from having too few white blood cells)
  • Easy bruising or bleeding (from having too few blood platelets)
  • Fatigue (from having too few red blood cells)

These side effects usually go away after treatment is finished. There are often ways to lessen these side effects. For example, drugs can be given to help prevent or reduce nausea and vomiting. Be sure to ask your doctor or nurse about medicines to help reduce side effects, and let him or her know if you have side effects, so they can be managed effectively.

Some drugs can have other side effects. For example, cisplatin and carboplatin can damage nerves (called neuropathy). This can sometimes lead to hearing loss or symptoms in the hands and feet such as pain, burning or tingling sensations, sensitivity to cold or heat, or weakness. This usually goes away once treatment is stopped, but it can last a long time in some people.

Be sure to report any side effects or changes you notice while getting chemo to your medical team so that you can get them treated promptly. In some cases, the doses of the drugs may need to be reduced or treatment may need to be delayed or stopped to keep the effects from getting worse.

To learn more about chemotherapy, see Chemotherapy.

The American Cancer Society medical and editorial content team
Our team is made up of doctors and master's-prepared nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.

Last Medical Review: May 18, 2015 Last Revised: February 17, 2016

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