Cancer starts when cells in the body begin to grow out of control and crowd out normal cells. Cells in nearly any part of the body can become cancer, and can then spread to other areas of the body. To learn more about cancer and how it starts and spreads, see What Is Cancer?
Neuroblastoma is a cancer that starts in certain very early forms of nerve cells, most often found in an embryo or fetus. (The term neuro refers to nerves, while blastoma refers to a cancer that starts in immature or developing cells). This type of cancer occurs most often in infants and young children.
The types of cancers that develop in children are often different from the types that develop in adults. To learn more about , see What Are the Differences Between Cancers in Adults and Children?
To understand neuroblastoma, it helps to know about the sympathetic nervous system, which is where these tumors start.
The brain, spinal cord, and the nerves that reach out from them to all areas of the body are all part of the nervous system. The nervous system is needed for thinking, sensation, and movement, among other things.
Part of the nervous system also controls body functions we are rarely aware of, such as heart rate, breathing, blood pressure, digestion, and other functions. This part of the nervous system is known as the autonomic nervous system.
The sympathetic nervous system is part of the autonomic nervous system. It includes:
The main cells that make up the nervous system are called nerve cells or neurons. These cells interact with other types of cells in the body by releasing tiny amounts of chemicals (hormones). This is important, because neuroblastoma cells often release certain chemicals that can cause symptoms (see Signs and Symptoms of Neuroblastoma).
Neuroblastomas are cancers that start in early nerve cells (called neuroblasts) of the sympathetic nervous system, so they can be found anywhere along this system.
Some neuroblastomas grow and spread quickly, while others grow slowly. Sometimes, in very young children, the cancer cells die for no reason and the tumor goes away on its own. In other cases, the cells sometimes mature on their own into normal ganglion cells and stop dividing (which makes the tumor a benign ganglioneuroma - see below).
Not all childhood autonomic nervous system tumors are malignant (cancerous). Some tumors are benign (non-cancerous), and some can have both benign and cancer cells within the same tumor.
If a child is thought to have one of these tumors, it is usually removed by surgery and looked at carefully with a microscope to see if it has areas of cancer cells (which would make it a ganglioneuroblastoma). If the final diagnosis is ganglioneuroma, no other treatment is needed. If it’s found to be a ganglioneuroblastoma, it’s treated the same way as a neuroblastoma.
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Park JR, Hogarty MD, Bagatell R, et al. Chapter 23: Neuroblastoma. In: Blaney SM, Adamson PC, Helman LJ, eds. Pizzo and Poplack’s Principles and Practice of Pediatric Oncology. 8th ed. Philadelphia Pa: Lippincott Williams & Wilkins; 2021.
National Cancer Institute. Neuroblastoma Treatment (PDQ). 2020. Accessed at https://www.cancer.gov/types/neuroblastoma/hp/neuroblastoma-treatment-pdq on February 22, 2021.
Shohet JM, Nuchtern JG. Clinical presentation, diagnosis, and staging evaluation of neuroblastoma. UpToDate. 2021. Accessed at https://www.uptodate.com/contents/clinical-presentation-diagnosis-and-staging-evaluation-of-neuroblastoma on March 3, 2021.
Shohet JM, Nuchtern JG. Epidemiology, pathogenesis, and pathology of neuroblastoma. UpToDate. 2021. Accessed at https://www.uptodate.com/contents/epidemiology-pathogenesis-and-pathology-of-neuroblastoma on February 22, 2021.
Last Revised: April 28, 2021