Cancer starts when cells in the body begin to grow out of control. Cells in nearly any part of the body can become cancer, and can spread to other areas of the body. To learn more about how cancers start and spread, see What Is Cancer? For information about the differences between childhood cancers and adult cancers, see Cancer in Children.
Sarcomas are cancers that develop from connective tissues in the body, such as muscles, fat, bones, the linings of joints, or blood vessels. There are many types of sarcomas.
Rhabdomyosarcoma (RMS) is a type of sarcoma made up of cells that normally develop into skeletal (voluntary) muscles. These are muscles that we control to move parts of our body.
Well before birth, cells called rhabdomyoblasts (which will eventually form skeletal muscles) begin to form. These are the cells that can develop into RMS. Because this is a cancer of very early forms of muscle cells, it is much more common in children, although it does sometimes occur in adults.
We might think of our skeletal muscles as being mainly in our arms and legs, but RMS can start nearly anywhere in the body, even in some parts of the body that don’t normally have skeletal muscle.
Common sites of RMS include:
There are 2 main types of RMS, along with some less common types.
ERMS usually affects children in their first 5 years of life, but it can occur at older ages as well.
ERMS tends to occur in the head and neck area, bladder, vagina, or in or around the prostate and testicles.
Two subtypes of ERMS, botryoid and spindle cell rhabdomyosarcomas, tend to have a better prognosis (outlook) than the more common conventional form of ERMS.
ARMS typically affects all age groups equally. It makes up a larger portion of RMS in older children, teens, and adults than in younger children (because ERMS is less common at older ages).
ARMS most often occurs in large muscles of the trunk, arms, and legs.
ARMS tends to grow faster than ERMS, and it usually requires more intense treatment. However, in some cases of ARMS, the cancer cells lack certain gene changes, which makes these cancers act more like ERMS (and allows doctors to give less intense treatment).
Anaplastic rhabdomyosarcoma (also called pleomorphic rhabdomyosarcoma) is an uncommon type that occurs mainly in adults and is very rare in children.
Some doctors also group undifferentiated sarcomas with the rhabdomyosarcomas. Using lab tests, doctors can tell that these cancers are sarcomas, but the cells don’t have any features that help classify them further.
Both of these uncommon cancers tend to grow quickly and usually require intensive treatment.
Most rhabdomyosarcomas develop in children and teens, but they can also occur in adults. Adults are more likely to have faster-growing types of RMS and to have them in parts of the body that are harder to treat. Because of this, RMS in adults is often harder to treat effectively.
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National Cancer Institute. Childhood Rhabdomyosarcoma Treatment (PDQ®). 2018. Accessed at www.cancer.gov/types/soft-tissue-sarcoma/hp/rhabdomyosarcoma-treatment-pdq on May 21, 2018.
Okcu MF, Hicks J. Rhabdomyosarcoma in childhood and adolescence: Epidemiology, pathology, and molecular pathogenesis. UpToDate. Accessed at www.uptodate.com/contents/rhabdomyosarcoma-in-childhood-and-adolescence-epidemiology-pathology-and-molecular-pathogenesis on May 21, 2018.
Wexler LH, Skapek SX, Helman LJ. Chapter 31: Rhabdomyosarcoma. In: Pizzo PA, Poplack DG, eds. Principles and Practice of Pediatric Oncology. 7th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2016.
Last Revised: July 16, 2018