After Non-Hodgkin Lymphoma Treatment

For many people with non-Hodgkin lymphoma (NHL), treatment can destroy the lymphoma. Finishing treatment can be both stressful and exciting. You may be relieved to finish treatment, but you might find it hard not to worry about the lymphoma coming back (recurring). This is a very common concern if you’ve had cancer.

For some people, the lymphoma may never go away completely. Some people may get regular treatments with chemo, radiation, or other therapies to help keep the lymphoma in check and relieve symptoms for as long as possible. Learning to live with lymphoma that doesn’t go away can be difficult and very stressful.

No matter what your situation is, there are steps you can take to live well, both physically and emotionally.

Follow-up care after non-Hodgkin lymphoma

After finishing treatment for non-Hodgkin lymphoma, you’ll still see your cancer care team regularly. You may have tests to look for signs that the cancer has come back.

Let your care team know about any new symptoms or problems, because these could be caused by the lymphoma coming back, by a new disease, or by a second cancer.

What is a survivorship care plan?

Talk with your healthcare team about developing a survivorship care plan for you. This plan can guide your next steps after treatment, including follow-up appointments and ways to stay healthy.

A survivorship plan might include:

  • A suggested schedule for follow-up exams and tests
  • A timeline for other tests, such as screening for other cancers or monitoring for long-term health effects from your cancer or treatment
  • A list of possible late or long-term side effects from your treatment, including what to watch for and when to contact your healthcare team
  • Diet and physical activity suggestions

Many people with non-Hodgkin lymphoma are cured, but treatment can lead to health problems in the future. See your healthcare team regularly, get the recommended cancer screening tests, and tell your care team about any changes you notice in how you feel.

What is the follow-up schedule after NHL?

Your cancer care team will still watch you closely, even after you finish treatment. Lymphoma can sometimes come back many years after treatment, so it is very important to go to all your follow-up appointments.

  • For aggressive lymphomas such as DLBCL, follow-up visits are typically every 3 to 6 months for the first 2 years, then less often through year 5, and yearly after that.
  • For slow-growing lymphomas, follow-up visits often continue for life, since these lymphomas can come back even many years after treatment. Your exact schedule will depend on your individual situation and the type of treatment you had. 

Exams and tests

During your follow-up visits, your cancer care team will examine you and ask about any symptoms you’re having. They may order blood or imaging tests.

Imaging tests

You may get imaging tests based on the type, location, and stage of your lymphoma.

  • CT scans are the standard imaging tool used during routine follow-up to check for signs of lymphoma returning.
  • PET/CT scans are generally not recommended for routine follow-up if a person had a complete response to treatment. These scans have not been shown to improve outcomes and can lead to false-positive results.
  • PET/CT may be used if your cancer care team is concerned about recurrence based on your symptoms or exam findings.

Blood tests

You may need frequent blood tests to:

  • Check that you’ve recovered from treatment.
  • Look for signs of problems, such as lymphoma recurrence.

Watching for signs of MDS or leukemia: Blood tests will help your cancer care team watch for a bone marrow condition called myelodysplastic syndrome (MDS). This can develop as a late effect of certain chemotherapy drugs or radiation therapy. It can sometimes progress to leukemia.

It is also possible to develop leukemia a few years after being treated for lymphoma.

Questions to ask your care team

  • What type of follow-up will I need after treatment?
  • What side effects should I watch for?
  • How will we know if the lymphoma comes back? What should I watch for?
  • What will my options be if the cancer comes back?

Staying prepared and organized

Even after treatment, it’s very important to stay organized and on top of your health. Keeping your records and health insurance coverage in order makes it easier to manage your follow-up care, future checkups, and any new concerns that may come up.

Keep your health insurance

It’s very important to keep health insurance as a lymphoma survivor. Insurance can help cover the cost of follow-up visits, tests, and any care you may need in the future. No one wants to think about their cancer coming back, but it’s best to be prepared.

Save your medical records

At some point, you might see a new doctor who doesn’t know your cancer history. Keep copies of your medical records so you can easily share the details of your diagnosis and treatment when needed.

Can I lower my risk of lymphoma progressing or coming back?

You might want to know if you can do anything to lower your risk of non-Hodgkin lymphoma coming back, such as exercising, eating a certain type of diet, or taking nutritional supplements.

At this time, we don’t know for sure if there are things you can do to lower this risk. Some things might be helpful, but more research is needed to know for sure.

Adopting healthy behaviors

It might help to adopt healthy behaviors like eating well, getting regular physical activity, staying at a healthy weight, and not smoking. But no one knows for sure.

However, we do know that these types of changes can have other positive effects on your health. These positive effects extend beyond your risk of lymphoma or other cancers.

About dietary supplements

So far, no dietary supplements have been shown to clearly help lower the risk of non-Hodgkin lymphoma progressing or coming back. That includes vitamins, minerals, and herbal products. This does not mean that no supplements will help. But it’s important to know that none have been proven to do so.

In the United States, dietary supplements aren’t regulated like medicines. They don't have to be proven effective or even safe to be sold, although there are limits on what they’re allowed to claim they can do.

Talk to your healthcare team before taking any type of nutritional supplement. They can help you decide which ones are safe and which ones might be harmful.

If the lymphoma comes back

If the lymphoma does come back at some point, your treatment options will depend on the type of lymphoma, where it is, what treatments you’ve had before, how long it’s been since treatment, and your current health and preferences.

For more general information on dealing with a recurrence, see What Is Cancer Recurrence?

Could I get a second cancer after treatment?

People who’ve had non-Hodgkin lymphoma can still get other cancers. In fact, lymphoma survivors are at higher risk for some types of cancer, including:

If you were treated with chest radiation:

  • Radiation therapy to the chest increases the risk of breast cancer in women who were treated before age 30.
  • The risk of mesothelioma is also increased in people who were treated with chest radiation. This is a rare cancer of the outer lining of the lung. 

Screening for second cancers

Breast cancer screening

Women who were treated with chest radiation have an increased risk of breast cancer.

Because of this risk, the American Cancer Society recommends these women should get yearly breast MRIs in addition to mammograms and clinical breast exams. This should begin at age 30.

Some experts recommend screening should start 8 to 10 years after treatment or at age 40, whichever is earlier.

Screening for other cancers

Survivors of non-Hodgkin lymphoma should also follow the American Cancer Society guidelines for the early detection of cancer, such as those for colorectal and lung cancer.

Most experts do not recommend any other testing to look for second cancers unless you have symptoms.

Screening for people who were treated as children or young adults

The Children’s Oncology Group has screening guidelines for cancer survivors who were treated as children, teens, or young adults. These can be found at www.survivorshipguidelines.org.

Can I lower my risk of getting a second cancer?

You can take steps to help lower your risk of a second cancer and stay as healthy as possible.

For example, it’s important to stay away from tobacco products. Smoking increases the risk of many cancers, including some of the second cancers seen in people who’ve had non-Hodgkin lymphoma.

To help maintain good health, it’s also important to:

  • Get to and stay at a healthy weight.
  • Keep physically active and limit the time you spend sitting or lying down.
  • Follow a healthy eating pattern that includes plenty of fruits, vegetables, and whole grains.
  • Limit red and processed meats, sugary drinks, and highly processed foods.
  • Avoid alcohol. If you do drink, have no more than 1 drink per day for women or 2 per day for men.

These steps may also lower the risk of other health problems, including heart disease.

See Second Cancers in Adults for more information.

Social and emotional health after cancer

Some amount of feeling depressed, anxious, or worried is common when cancer is a part of your life. Some feelings might last a long time and can include:

  • Dealing with physical changes that happen because of treatment
  • Worrying about the cancer returning or new health problems developing
  • Being treated differently or discriminated against by friends, partners, coworkers, employers, and others

You might also feel:

  • Resentful for having had cancer
  • Resentful for going through treatment when others didn’t have to
  • Guilty for surviving cancer when other friends with cancer did not

Learn more in Life After Cancer.

If your feelings are getting in the way of your daily life, consider reaching out for support. The American Cancer Society is here to help. The National Cancer Information Center is available 24/7 at 1-800-227-2345 to discuss support resources in your community.

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Developed by the American Cancer Society medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).

Cheson BD, Fisher RI, Barrington SF, et al. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 2014;32(27):3059–3068.

National Comprehensive Cancer Network (NCCN). Practice Guidelines in Oncology: B-cell Lymphomas. Version 3.2026. Accessed at https://www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf on May 4, 2026.

National Comprehensive Cancer Network (NCCN). Practice Guidelines in Oncology: T-cell Lymphomas. Version 2.2026. Accessed at https://www.nccn.org/professionals/physician_gls/pdf/t-cell.pdf on May 4, 2026.

Rock CL, Thomson CA, Sullivan KR, et al. American Cancer Society nutrition and physical activity guideline for cancer survivors. CA Cancer J Clin. 2022;72(3):230–262.

Thandra KC, Barsouk A, Saginala K, et al. Epidemiology of non-Hodgkin's lymphoma. Med Sci. 2021;9(1):5.

Last Revised: October 12, 2026

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